Dynamic microtubule plus end architecture in presence of EB3.
Saunders HAJ, van den Berg CM, Hoogebeen RA, Schweizer D, Stecker KE, Roepman R, Howes SC, Akhmanova A
Nat Struct Mol Biol (2025) [ Pubmed: 39856351 DOI: doi:10.1038/s41594-025-01483-y ]
Microtubule plus end architecture in presence of the ciliary tip module.
Saunders HAJ, van den Berg CM, Hoogebeen RA, Schweizer D, Stecker KE, Roepman R, Howes SC, Akhmanova A
Nat Struct Mol Biol (2025) [ Pubmed: 39856351 DOI: doi:10.1038/s41594-025-01483-y ]
- Cspp1 (Cellular component from Homo sapiens)
- Cep104 (Cellular component from Homo sapiens)
- Togaram1 (Cellular component from Mus musculus)
- Ccdc66 (Cellular component from Homo sapiens)
- Tubulin (Cellular component from Sus scrofa domesticus)
- Eb3 (Cellular component from Homo sapiens)
- Microtubules with sub-stoichiometric eb3 and the ciliary tip module (Complex)
- Armc9 (Cellular component from Homo sapiens)
Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS
Zhao J, Shen Q, Yong X, Li X, Tian X, Sun S, Xu Z, Zhang X, Zhang L, Yang H, Shao Z, Xu H, Jiang Y, Zhang Y, Yan W
Nat Struct Mol Biol (2025) [ Pubmed: 39824976 DOI: doi:10.1038/s41594-024-01470-9 ]
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Lysosomal cholesterol signaling protein (93 kDa, Protein from Homo sapiens)
- Cholesterol-bound lychos (Complex from Homo sapiens)
- [(2r)-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] octadecanoate (720 Da, Ligand)
- Cholesterol (386 Da, Ligand)
RNA polymerase II bound to Alu RNA right arm
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8qep
Q-score: 0.55
Tluckova K, Kaczmarek B, Salmazo A, Bernecky C
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01448-7 Pubmed: 39762629 ]
- Alu rna right arm (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerase subunit (19 kDa, Protein from Sus scrofa domesticus)
- Rna polymerase ii, i and iii subunit k (7 kDa, Protein from Sus scrofa domesticus)
- Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from Sus scrofa domesticus)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (14 kDa, Protein from Sus scrofa domesticus)
- Dna-directed rna polymerase subunit (217 kDa, Protein from Sus scrofa domesticus)
- Rna polymerase ii (Complex from Sus scrofa domesticus)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (17 kDa, Protein from Sus scrofa domesticus)
- Dna-directed rna polymerase ii subunit e (24 kDa, Protein from Sus scrofa domesticus)
- Dna-directed rna polymerase subunit beta (134 kDa, Protein from Sus scrofa domesticus)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from Sus scrofa domesticus)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (7 kDa, Protein from Sus scrofa domesticus)
- Rna polymerase ii bound to alu rna right arm (48 kDa, Complex)
- Dna-directed rna polymerase ii subunit rpb11-a (13 kDa, Protein from Sus scrofa domesticus)
Cryo-EM structure of the anamorelin-bound ghrelin receptor and Gq complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8jsr
Q-score: 0.566
Shiimura Y, Im D, Tany R, Asada H, Kise R, Kurumiya E, Wakasugi-Masuho H, Yasuda S, Matsui K, Kishikawa JI, Kato T, Murata T, Kojima M, Iwata S, Masuho I
Nat Struct Mol Biol (2025) [ Pubmed: 39833471 DOI: doi:10.1038/s41594-024-01481-6 ]
- Anamorelin-bound ghrelin receptor in complex with gq (190 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (42 kDa, Protein from Homo sapiens)
- Engineered g-alpha-q (41 kDa, Protein from Homo sapiens)
- 2-azanyl-n-[(2r)-1-[(3r)-3-[dimethylamino(methyl)carbamoyl]-3-(phenylmethyl)piperidin-1-yl]-3-(1h-indol-3-yl)-1-oxidanylidene-propan-2-yl]-2-methyl-propanamide (546 Da, Ligand)
- Growth hormone secretagogue receptor type 1 (58 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nb35 (14 kDa, Protein from Lama glama)
- Scfv16 (27 kDa, Protein from Mus musculus)
H3K4me3 nucleosome bound to PRC2_AJ1-450
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vmn
Q-score: 0.39
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Histone h4 (11 kDa, Protein from Homo sapiens)
- H3k4me3 nucleosome core particle bound to prc2_aj1-450 (Complex from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Histone h2b (10 kDa, Protein from Xenopus laevis)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h2a (11 kDa, Protein from Xenopus laevis)
PRC2_AJ1-450 bound to H3K36me3 with histone H3 tail engaged
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vnv
Q-score: 0.357
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Prc2_aj1-450 bound to h3k36me3 modified nucleosome with tail engaged (Complex from Homo sapiens)
- Isoform 2 of histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (31 kDa, Protein from Homo sapiens)
- Eed (50 kDa, Protein from Homo sapiens)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Rbap48 (47 kDa, Protein from Homo sapiens)
- Dna (26-mer) (7 kDa, DNA from Homo sapiens)
- H3k36me3-modified histone h3 (2 kDa, Protein from Homo sapiens)
H3K36me3-modified nucleosome bound to PRC2_AJ1-450 with histone H3 tail disengaged
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vo0
Q-score: 0.258
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- H3k36me3 modified nucleosome core particle (Complex from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h4 (8 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (9 kDa, Protein from Xenopus laevis)
- Histone h4 (8 kDa, Protein from Homo sapiens)
- Dna (157-mer) (48 kDa, DNA from Homo sapiens)
- Histone h2a (11 kDa, Protein from Xenopus laevis)
- Histone h2b 1.1 (9 kDa, Protein from Xenopus laevis)
- Histone h3.2 (11 kDa, Protein from Homo sapiens)
PRC2_AJ119-450, JARID2_107-121 / Nuc_unmodified
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
PRC2 AJ119-450 bound to JARID2 113-121,R115A peptide and unmodified nucleosome
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]