WEE1 bound to CRBN-DDB1 via compound 10 (CRBN closed conformation)
Razumkov H, Jiang Z, Baek K, You I, Geng Q, Donovan KA, Tang MT, Metivier RJ, Mageed N, Seo P, Li Z, Byun WS, Hinshaw SM, Sarott RC, Fischer ES, Gray NS
J Am Chem Soc (2024) 146 pp. 31433-31443 [ DOI: doi:10.1021/jacs.4c06127 Pubmed: 39499896 ]
WEE1 bound to CRBN-DDB1 via compound 10 (CRBN open conformation)
Razumkov H, Jiang Z, Baek K, You I, Geng Q, Donovan KA, Tang MT, Metivier RJ, Mageed N, Seo P, Li Z, Byun WS, Hinshaw SM, Sarott RC, Fischer ES, Gray NS
J Am Chem Soc (2024) 146 pp. 31433-31443 [ DOI: doi:10.1021/jacs.4c06127 Pubmed: 39499896 ]
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant, scFv16, and dopamine
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG
Nat Commun (2024) 15 pp. 6643-6643 [ Pubmed: 39103320 DOI: doi:10.1038/s41467-024-50964-z ]
- D(2) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Human drd2 in complex with heterotrimeric g protein goa (k46e), scfv16, and dopamine (120 kDa, Complex from Homo sapiens)
- Scfv16 (28 kDa, Protein from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG
Nat Commun (2024) 15 pp. 6643-6643 [ Pubmed: 39103320 DOI: doi:10.1038/s41467-024-50964-z ]
- D(2) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Human drd2 in complex with heterotrimeric g protein goa (k46e) and dopamine (120 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of transglutaminase 2 bound to GDP
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tr9
Q-score: 0.507
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK
Commun Biol (2024) 7 pp. 982-982 [ DOI: doi:10.1038/s42003-024-06672-x Pubmed: 39134806 ]
- Transglutaminase 2 bound to gdp (Complex from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Protein-glutamine gamma-glutamyltransferase 2 (77 kDa, Protein from Homo sapiens)
Cryo-EM map of transglutaminase 2 bound to calcium
Aplin C, Zielinski KA, Pabit S, Ogunribido D, Katt WP, Pollack L, Cerione RA, Milano SK
Commun Biol (2024) 7 pp. 982-982 [ DOI: doi:10.1038/s42003-024-06672-x Pubmed: 39134806 ]
Cryo-EM structure of the ZBTB9 BTB domain filament
Resolution: 8.1 Å
EM Method: Helical reconstruction
Fitted PDBs: 9b9v
Q-score: 0.168
Park PMC, Park J, Brown J, Hunkeler M, Roy Burman SS, Donovan KA, Yoon H, Nowak RP, Slabicki M, Ebert BL, Fischer ES
Mol Cell (2024) 84 pp. 2511-2524.e8 [ DOI: doi:10.1016/j.molcel.2024.06.010 Pubmed: 38996460 ]
Cryo-EM structure of DDB1deltaB-DDA1-DCAF5
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8tl6
Q-score: 0.598
Radko-Juettner S, Yue H, Myers JA, Carter RD, Robertson AN, Mittal P, Zhu Z, Hansen BS, Donovan KA, Hunkeler M, Rosikiewicz W, Wu Z, McReynolds MG, Roy Burman SS, Schmoker AM, Mageed N, Brown SA, Mobley RJ, Partridge JF, Stewart EA, Pruett-Miller SM, Nabet B, Peng J, Gray NS, Fischer ES, Roberts CWM
Nature (2024) 628 pp. 442-449 [ DOI: doi:10.1038/s41586-024-07250-1 Pubmed: 38538798 ]
- Complex of ddb1deltab-dda1-dcaf5 (220 kDa, Complex from Homo sapiens)
- Ddb1- and cul4-associated factor 5 (108 kDa, Protein from Homo sapiens)
- Det1- and ddb1-associated protein 1 (14 kDa, Protein from Homo sapiens)
- Dna damage-binding protein 1 (96 kDa, Protein from Homo sapiens)
Human TRiC-PhLP2A complex in the closed state
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8i1u
Q-score: 0.506
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Aluminum fluoride (83 Da, Ligand)
- Complex of tric/cct-phlp2a treated with atp-alfx (1 MDa, Complex from Homo sapiens)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Phlp2a (pdcl3) (Complex)
- Human tric/cct complex (Complex from Homo sapiens)
Human TRiC-PhLP2A-actin complex in the closed state
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 8ib8
Q-score: 0.271
Park J, Kim H, Gestaut D, Lim S, Opoku-Nsiah KA, Leitner A, Frydman J, Roh SH
Nat Commun (2024) 15 pp. 1007-1007 [ Pubmed: 38307855 DOI: doi:10.1038/s41467-024-45242-x ]
- Complex of tric/cct, phlp2a, and actin treated with atp-alfx (1 MDa, Complex)
- T-complex protein 1 subunit zeta (58 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit theta (59 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit delta (57 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit beta (57 kDa, Protein from Homo sapiens)
- Human actin (Complex from Homo sapiens)
- T-complex protein 1 subunit epsilon (59 kDa, Protein from Homo sapiens)
- Phosducin-like protein 3 (27 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit alpha (60 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit eta (59 kDa, Protein from Homo sapiens)
- Actb protein (fragment) (41 kDa, Protein from Homo sapiens)
- T-complex protein 1 subunit gamma (60 kDa, Protein from Homo sapiens)
- Phlp2a (pdcl3) (Complex from Homo sapiens)
- Human tric/cct complex (Complex from Homo sapiens)