HPV16 L1 pentamer in complex with Fab F5-196
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8yeh
Q-score: -0.024
To Be Published
- Hpv16 l1 pentamer in complex with fab f5-196 (Complex)
- Light chain of f5-196 (11 kDa, Protein from Homo sapiens)
- Heavy chain of f5-196 (13 kDa, Protein from Homo sapiens)
- Fabf5-196 (Complex from Homo sapiens)
- Major capsid protein l1 (50 kDa, Protein from Human papillomavirus type 16)
- Hpv16 l1 pentamer (Complex from Human papillomavirus 16)
Human E3 ligase E6AP in complex with HPV16-E6 and p53
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 9cht
Q-score: 0.263
Kenny S, Iyer S, Gabel CA, Tegenfeldt N, DeMarco AG, Hall MC, Chang L, Davisson VJ, Pol SV, Das C
Structure (2025) [ DOI: doi:10.1016/j.str.2024.12.013 Pubmed: 39818213 ]
- Protein e6 (18 kDa, Protein from Human papillomavirus 16)
- Immunoglobulin g-binding protein g/cellular tumor antigen p53 fusion protein (43 kDa, Protein from Homo sapiens)
- Ubiquitin-protein ligase e3a (102 kDa, Protein from Homo sapiens)
- Ternary complex of e6ap with viral factor e6 and neosubstrate p53 (Complex from Homo sapiens)
Structure of E6AP-E6 complex in Att1 state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8jrn
Q-score: 0.531
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
Structure of E6AP-E6 complex in Att2 state
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8jro
Q-score: 0.492
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
Structure of E6AP-E6 complex in Att3 state
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8jrp
Q-score: 0.34
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (17 kDa, Protein from Human papillomavirus 16)
Structure of E6AP-E6 complex in Det1 state
Resolution: 4.15 Å
EM Method: Single-particle
Fitted PDBs: 8jrq
Q-score: 0.186
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
Structure of E6AP-E6 complex in Det2 state
Resolution: 4.35 Å
EM Method: Single-particle
Fitted PDBs: 8jrr
Q-score: 0.164
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ DOI: doi:10.1038/s41467-024-47586-w Pubmed: 38670961 ]
- Protein e6 (16 kDa, Protein from Human papillomavirus 16)
- E6ap-e6 complex (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8gcr
Q-score: 0.468
Wang JCK, Baddock HT, Mafi A, Foe IT, Bratkowski M, Lin TY, Jensvold ZD, Preciado Lopez M, Stokoe D, Eaton D, Hao Q, Nile AH
Nat Commun (2024) 15 pp. 1842-1842 [ DOI: doi:10.1038/s41467-024-45920-w Pubmed: 38418456 ]
- Zinc ion (65 Da, Ligand)
- E6ap (Complex from Homo sapiens)
- Maltose/maltodextrin-binding periplasmic protein,protein e6 (61 kDa, Protein from Human papillomavirus type 16)
- Ternary complex of hpv16 e6, e6ap, and p53 (Complex)
- Ubiquitin-protein ligase e3a (104 kDa, Protein from Homo sapiens)
- Cellular tumor antigen p53 (24 kDa, Protein from Homo sapiens)
- Hpv16 e6 - mbp fusion (Complex from Escherichia coli)
- P53 (Complex from Homo sapiens)
Monomeric E6AP-E6-p53 ternary complex
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8r1f
Q-score: 0.316
Sandate CR, Chakraborty D, Kater L, Kempf G, Thoma NH
bioRxiv (2023) [ DOI: doi:10.1101/2023.11.01.565136 ]
- Zinc ion (65 Da, Ligand)
- Cellular tumor antigen p53 (46 kDa, Protein from Homo sapiens)
- Ubiquitin-like protein smt3,protein e6 (31 kDa, Protein from Human papillomavirus type 16)
- Ubiquitin-protein ligase e3a (103 kDa, Protein from Homo sapiens)
- Monomeric e6ap-e6-p53 ternary complex (176 kDa, Complex from Homo sapiens)
Dimeric ternary structure of E6AP-E6-p53
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 8r1g
Q-score: 0.175
Sandate CR, Chakraborty D, Kater L, Kempf G, Thoma NH
bioRxiv (2023) [ DOI: doi:10.1101/2023.11.01.565136 ]
- Zinc ion (65 Da, Ligand)
- Cellular tumor antigen p53 (46 kDa, Protein from Homo sapiens)
- Ubiquitin-like protein smt3,protein e6 (31 kDa, Protein from Human papillomavirus type 16)
- Ubiquitin-protein ligase e3a (103 kDa, Protein from Homo sapiens)
- Dimeric e6ap-e6-p53 ternary complex (352 kDa, Complex from Homo sapiens)