Bangaru S, Jackson AM, Copps J, Fernandez-Quintero ML, Torres JL, Richey ST, Nogal B, Sewall LM, de la Pena AT, Rehman A, Guebre-Xabier M, Girard B, Das R, Corbett-Helaire KS, Seder RA, Graham BS, Edwards DK, Patel N, Smith G, Ward AB
bioRxiv (2024) [ DOI: doi:10.1101/2024.12.11.628030 Pubmed: 39713412 ]
Cryo-EM structure of mAb8-24 bound to 426c.WITO.TM.SOSIP
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 9bge
Q-score: 0.373
Agrawal P, Knudsen ML, MacCamy A, Hurlburt NK, Khechaduri A, Salladay KR, Kher GM, Kallur Siddaramaiah L, Stuart AB, Bontjer I, Shen X, Montefiori D, Gristick HB, Bjorkman PJ, Sanders RW, Pancera M, Stamatatos L
J Virol (2024) 98 pp. e0074424-e0074424 [ DOI: doi:10.1128/jvi.00744-24 Pubmed: 39240111 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fv domain of heavy chain of mab 8-24 (25 kDa, Protein from Mus musculus)
- Fv domain of light chain of mab 8-24 (22 kDa, Protein from Mus musculus)
- 426c.wito.tm.sosip (69 kDa, Protein from Human immunodeficiency virus 1)
- Complex of 426c.wito.tm.sosip bound to three mab 8-24 fabs (210 kDa, Complex from Homo sapiens)
10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ Pubmed: 38816615 DOI: doi:10.1038/s41590-024-01833-w ]
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8geh
Q-score: 0.44
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ Pubmed: 38480881 DOI: doi:10.1038/s41586-024-07153-1 ]
- Complex of beta-2 adrenergic receptor and gs heterotrimer (Complex)
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8gei
Q-score: 0.43
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ Pubmed: 38480881 DOI: doi:10.1038/s41586-024-07153-1 ]
- Complex of beta-2 adrenergic receptor and gs heterotrimer (Complex)
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8gej
Q-score: 0.413
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ Pubmed: 38480881 DOI: doi:10.1038/s41586-024-07153-1 ]
- Complex of beta-2 adrenergic receptor and gs heterotrimer (Complex)
- (5r,6r)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol (209 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Beta-2 adrenergic receptor (51 kDa, Protein from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8gh0
Q-score: 0.426
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ Pubmed: 38480881 DOI: doi:10.1038/s41586-024-07153-1 ]
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8gh1
Q-score: 0.408
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ Pubmed: 38480881 DOI: doi:10.1038/s41586-024-07153-1 ]
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ Pubmed: 38480881 DOI: doi:10.1038/s41586-024-07153-1 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Protein from Homo sapiens)
- Complex of beta-2 adrenergic receptor and gs heterotrimer, 10 sec post gtp treatment (Complex from Homo sapiens)
- Beta-2 adrenergic receptor (Protein from Homo sapiens)
Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G
Nature (2024) 629 pp. 1182-1191 [ Pubmed: 38480881 DOI: doi:10.1038/s41586-024-07153-1 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Protein from Homo sapiens)
- Complex of beta-2 adrenergic receptor and gs heterotrimer, 10 sec post gtp treatment (Complex from Homo sapiens)
- Beta-2 adrenergic receptor (Protein from Homo sapiens)