Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8st0
Q-score: 0.567
Mazzaferro S, Kang G, Natarajan K, Hibbs RE, Sine SM
Br.J.Pharmacol. (2024) 181 pp. 1973-1992 [ DOI: doi:10.1111/bph.16321 Pubmed: 38454578 ]
- Neuronal acetylcholine receptor subunit beta-2 (55 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Igg1 heavy chain (51 kDa, Protein from Mus musculus)
- Igg1 kappa light chain (26 kDa, Protein from Mus musculus)
- Sodium ion (22 Da, Ligand)
- A complex of three fab fragments with the 2alpha3beta stoichiometry of the full-length human alpha4beta2 nicotinic receptor bound to acetylcholine (Complex from Homo sapiens)
- N-octane (114 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-4 (67 kDa, Protein from Homo sapiens)
- Acetylcholine (146 Da, Ligand)
ATTRV20I amyloid fibril from hereditary ATTR amloidosis
Resolution: 3.39 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pke
Q-score: 0.485
Steinebrei M, Baur J, Pradhan A, Kupfer N, Wiese S, Hegenbart U, Schonland SO, Schmidt M, Fandrich M
Nat Commun (2023) 14 pp. 7623-7623 [ DOI: doi:10.1038/s41467-023-43301-3 Pubmed: 37993462 ]
- Attrv20i amyloid fibril (Complex from Homo sapiens)
- Transthyretin (13 kDa, Protein from Homo sapiens)
ATTRG47E amyloid fibril from hereditary ATTR amloidosis
Resolution: 2.3673 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pkf
Q-score: 0.589
Steinebrei M, Baur J, Pradhan A, Kupfer N, Wiese S, Hegenbart U, Schonland SO, Schmidt M, Fandrich M
Nat Commun (2023) 14 pp. 7623-7623 [ DOI: doi:10.1038/s41467-023-43301-3 Pubmed: 37993462 ]
- Attrg47e amyloid fibril (Complex from Homo sapiens)
- Transthyretin (13 kDa, Protein from Homo sapiens)
ATTRV122I amyloid fibril from hereditary ATTR amloidosis
Resolution: 2.99 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pkg
Q-score: 0.499
Steinebrei M, Baur J, Pradhan A, Kupfer N, Wiese S, Hegenbart U, Schonland SO, Schmidt M, Fandrich M
Nat Commun (2023) 14 pp. 7623-7623 [ DOI: doi:10.1038/s41467-023-43301-3 Pubmed: 37993462 ]
- Transthyretin (13 kDa, Protein from Homo sapiens)
- Attrv122i amyloid fibril (Complex from Homo sapiens)
KCTD5/Cullin3/Gbeta1gamma2 Complex State B: Composite Map from RELION Multi-body Refinement
Resolution: 3.83 Å
EM Method: Single-particle
Fitted PDBs: 8u82
Q-score: 0.254
Nguyen DM, Rath DH, Devost D, Petrin D, Rizk R, Ji AX, Narayanan N, Yong D, Zhai A, Kuntz DA, Mian MUQ, Pomroy NC, Keszei AFA, Benlekbir S, Mazhab-Jafari MT, Rubinstein JL, Hebert TE, Prive GG
PNAS (2024) 121 pp. e2315018121-e2315018121 [ Pubmed: 38625940 DOI: doi:10.1073/pnas.2315018121 ]
- Gbg2_human (Protein from Homo sapiens)
- Kctd5_human (Protein from Homo sapiens)
- Cullin3 1-381 (Protein from Homo sapiens)
- Complex of substrate adaptor kctd5 with cullin-3 and substrate gbeta-gamma (Complex from Homo sapiens)
- Gbb1_human (Protein from Homo sapiens)
CryoEM Structure INO80core Hexasome complex composite map state1
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8oo7
Q-score: 0.556
Zhang M, Jungblut A, Kunert F, Hauptmann L, Hoffmann T, Kolesnikova O, Metzner F, Moldt M, Weis F, DiMaio F, Hopfner KP, Eustermann S
Science (2023) 381 pp. 313-319 [ Pubmed: 37384673 DOI: doi:10.1126/science.adf6287 ]
- Actin-related protein 5 (87 kDa, Protein from Thermochaetoides thermophila)
- Ino80 core module in complex with hexasome (861 kDa, Complex)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Chromatin-remodeling complex subunit ies6 (23 kDa, Protein from Thermochaetoides thermophila)
- Histones (Complex from Homo sapiens)
- Dna strand 1 (69 kDa, DNA from synthetic construct)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ruvb-like protein 2 (53 kDa, Protein from Thermochaetoides thermophila)
- Histone h2a (14 kDa, Protein from Homo sapiens)
- Chromatin remodeler ino80 (Complex from Thermochaetoides thermophila)
- Histone h2b (13 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Ruvb-like protein 1 (50 kDa, Protein from Thermochaetoides thermophila)
- Ino eighty subunit 2 (53 kDa, Protein from Thermochaetoides thermophila)
- Chromatin-remodeling atpase ino80 (130 kDa, Protein from Thermochaetoides thermophila)
- Dna strand 2 (70 kDa, DNA from synthetic construct)
- Dna (Complex from Synthetic construct)
- Histone h3.1 (15 kDa, Protein from Homo sapiens)
- Tetrafluoroaluminate ion (102 Da, Ligand)
The CryoEM structure of N49-P9.6-FR3 and PGT121 Fabs in complex with BG505 SOSIP.664
Resolution: 4.02 Å
EM Method: Single-particle
Fitted PDBs: 7uoj
Q-score: 0.392
Nguyen DN, Tolbert WD, Pazgier M
To Be Published
- N49-p9.6-fr3 fab light chain (21 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pgt121 fab heavy chain (25 kDa, Protein from Homo sapiens)
- N49-p9.6-fr3 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgt121 fab light chain (22 kDa, Protein from Homo sapiens)
- One bg505 sosip.644 trimer in complex with three n49-p9.6-fr3 fabs and three pgt121 fabs. (Complex from Homo sapiens)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8foz
Q-score: 0.763
O'Neill AG, Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL, Nomakuchi T, Izumi K, Kollman JM
J Biol Chem (2023) 299 pp. 105012-105012 [ Pubmed: 37414152 DOI: doi:10.1016/j.jbc.2023.105012 ]
- Inosinic acid (348 Da, Ligand)
- Inosine-5'-monophosphate dehydrogenase 2 (56 kDa, Protein from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Filament of inosine-5'-monophosphate dehydrogenase 2 - l245p mutant, bound to atp, imp, and nad+ (Complex from Homo sapiens)
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 8fuz
Q-score: 0.735
O'Neill AG, Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL, Nomakuchi T, Izumi K, Kollman JM
J Biol Chem (2023) 299 pp. 105012-105012 [ Pubmed: 37414152 DOI: doi:10.1016/j.jbc.2023.105012 ]
- Inosinic acid (348 Da, Ligand)
- Inosine-5'-monophosphate dehydrogenase 2 (56 kDa, Protein from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Filament of inosine-5'-monophosphate dehydrogenase 2 - l245p mutant, bound to gtp, atp, imp, and nad+ (Complex from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8g8f
Q-score: 0.573
O'Neill AG, Burrell AL, Zech M, Elpeleg O, Harel T, Edvardson S, Mor-Shaked H, Rippert AL, Nomakuchi T, Izumi K, Kollman JM
J Biol Chem (2023) 299 pp. 105012-105012 [ Pubmed: 37414152 DOI: doi:10.1016/j.jbc.2023.105012 ]
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Inosinic acid (348 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Inosine-5'-monophosphate dehydrogenase 2 (56 kDa, Protein from Homo sapiens)
- Filament of inosine-5'-monophosphate dehydrogenase 2 - l245p mutant, bound to atp, imp, and nad+ (Complex from Homo sapiens)