hBest2 1uM Ca2+ (Ca2+-bound) closed state
Resolution: 1.78 Å
EM Method: Single-particle
Fitted PDBs: 8d1e
Q-score: 0.789
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T
Nat Commun (2022) 13 pp. 3836-3836 [ Pubmed: 35789156 DOI: doi:10.1038/s41467-022-31437-7 ]
- Water (18 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Bestrophin-2 (46 kDa, Protein from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Hbest2 1um ca2+ (ca2+-bound) closed state (234 kDa, Complex from Homo sapiens)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
hBest2 5mM Ca2+ (Ca2+-bound) closed state
Resolution: 1.82 Å
EM Method: Single-particle
Fitted PDBs: 8d1f
Q-score: 0.787
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T
Nat Commun (2022) 13 pp. 3836-3836 [ Pubmed: 35789156 DOI: doi:10.1038/s41467-022-31437-7 ]
- Hbest2 5mm ca2+ (ca2+-bound) closed state (234 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Bestrophin-2 (46 kDa, Protein from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
hBest2 Ca2+-unbound closed state
Resolution: 1.94 Å
EM Method: Single-particle
Fitted PDBs: 8d1h
Q-score: 0.78
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T
Nat Commun (2022) 13 pp. 3836-3836 [ Pubmed: 35789156 DOI: doi:10.1038/s41467-022-31437-7 ]
- Water (18 Da, Ligand)
- Hbest2 ca2+-unbound closed state (234 kDa, Complex from Homo sapiens)
- Bestrophin-2 (46 kDa, Protein from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
hBest1 1uM Ca2+ (Ca2+-bound) closed state
Resolution: 1.82 Å
EM Method: Single-particle
Fitted PDBs: 8d1i
Q-score: 0.786
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T
Nat Commun (2022) 13 pp. 3836-3836 [ Pubmed: 35789156 DOI: doi:10.1038/s41467-022-31437-7 ]
- Calcium ion (40 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
- Hbest1 1um ca2+ (ca2+-bound) closed state (338 kDa, Complex from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Water (18 Da, Ligand)
bBest2_345 Ca2+-bound open state
Resolution: 1.93 Å
EM Method: Single-particle
Fitted PDBs: 8d1n
Q-score: 0.792
Owji AP, Wang J, Kittredge A, Clark Z, Zhang Y, Hendrickson WA, Yang T
Nat Commun (2022) 13 pp. 3836-3836 [ Pubmed: 35789156 DOI: doi:10.1038/s41467-022-31437-7 ]
- Water (18 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Bbest2_345 ca2+-bound open state (210 kDa, Complex from Bos taurus)
- Bestrophin (40 kDa, Protein from Bos taurus)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)