CryoEM Structure of NLRP3 NACHT domain in complex with G2394
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8etr
Q-score: 0.488
McBride C, Trzoss L, Povero D, Lazic M, Ambrus-Aikelin G, Santini A, Pranadinata R, Bain G, Stansfield R, Stafford JA, Veal J, Takahashi R, Ly J, Chen S, Liu L, Nespi M, Blake R, Katewa A, Kleinheinz T, Sujatha-Bhaskar S, Ramamoorthi N, Sims J, McKenzie B, Chen M, Ultsch M, Johnson M, Murray J, Ciferri C, Staben ST, Townsend MJ, Stivala CE
J Med Chem (2022) 65 pp. 14721-14739 [ DOI: doi:10.1021/acs.jmedchem.2c01250 Pubmed: 36279149 ]
- Nacht, lrr and pyd domains-containing protein 3 (63 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- (6s,8r)-n-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-6-(methylamino)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (431 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nlrp3 nacht domain (120 kDa, Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7k48
Q-score: 0.34
Wisedchaisri G, Tonggu L, Gamal El-Din TM, McCord E, Zheng N, Catterall WA
Mol Cell (2021) 81 pp. 38-48.e4 [ Pubmed: 33232657 DOI: doi:10.1016/j.molcel.2020.10.039 ]
- Complex of navab/nav1.7-vs2a chimera and m3-huwentoxin-iv (300 kDa, Complex)
- Maltose/maltodextrin-binding periplasmic protein,ion transport protein,sodium channel protein type 9 subunit alpha chimera (68 kDa, Protein from Arcobacter butzleri (strain RM4018))
- Navab/nav1.7-vs2a chimera (Complex from Escherichia coli)
- M3-huwentoxin-iv (Complex from Haplopelma schmidti)
- Mu-theraphotoxin-hs2a (3 kDa, Protein from Haplopelma schmidti)
GCGR-Gs signaling complex bound to a designed glucagon derivative
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6wpw
Q-score: 0.518
Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK
Science (2020) 369 [ DOI: doi:10.1126/science.aba3373 Pubmed: 32732395 ]
- Designed glucagon derivative (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gcgr (Complex from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Gcgr-gs signaling complex bound to a designed glucagon derivative (163 kDa, Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (44 kDa, Protein from Homo sapiens)
- Glucagon derivative zp3780 (3 kDa, Protein from synthetic construct)
- Gs (Complex from Homo sapiens)
- Glucagon receptor (56 kDa, Protein from Homo sapiens)
Structure of CD20 in complex with rituximab Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6vja
Q-score: 0.456
Rouge L, Chiang N, Steffek M, Kugel C, Croll TI, Tam C, Estevez A, Arthur CP, Koth CM, Ciferri C, Kraft E, Payandeh J, Nakamura G, Koerber JT, Rohou A
Science (2020) 367 pp. 1224-1230 [ DOI: doi:10.1126/science.aaz9356 Pubmed: 32079680 ]
- Rituximab fab light chain (23 kDa, Protein from Homo sapiens)
- Cd20 in complex with rituximab fab (135 kDa, Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- B-lymphocyte antigen cd20 (31 kDa, Protein from Homo sapiens)
- Rituximab fab heavy chain (23 kDa, Protein from Homo sapiens)