Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- N-[3-(2,5-difluoro-4-{[(4m)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide (513 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- P97/vcp aaa+ atpase r155h mutant/nsc804515 (536 kDa, Complex from Homo sapiens)
hPAD4 bound to Activating Fab hA362
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8smk
Q-score: 0.419
Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA
Nat Chem Biol (2024) 20 pp. 742-750 [ DOI: doi:10.1038/s41589-023-01535-8 Pubmed: 38308046 ]
- Protein-arginine deiminase type-4 (77 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Activating fab 362 heavy chain (24 kDa, Protein from Homo sapiens)
- Hpad4 bound to activating fab ha362 (248 kDa, Complex from Homo sapiens)
- Activating fab 362 light chain (23 kDa, Protein from Homo sapiens)
hPAD4 bound to inhibitory Fab hI365
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8sml
Q-score: 0.399
Zhou X, Kong S, Maker A, Remesh SG, Leung KK, Verba KA, Wells JA
Nat Chem Biol (2024) 20 pp. 742-750 [ DOI: doi:10.1038/s41589-023-01535-8 Pubmed: 38308046 ]
- Protein-arginine deiminase type-4 (77 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Fab hi365 light chain (23 kDa, Protein from Homo sapiens)
- Hpad4 bound to inhibitory fab hi365 (248 kDa, Complex from Homo sapiens)
- Fab hi365 heavy chain (24 kDa, Protein from Homo sapiens)
Cryo-EM structure of the T=4 lake sinai virus 2 virus-like capsid at pH 7.5
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7xgz
Q-score: 0.314
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC, Chen CJ
Nat Commun (2023) 14 pp. 545- [ DOI: doi:10.1038/s41467-023-36235-3 ]
- Lake sinai virus 2 (Virus from Lake Sinai virus 2)
- Capsid protein alpha (57 kDa, Protein from Lake Sinai virus 2)
Cryo-EM structure of the T=3 lake sinai virus 2 virus-like capsid at pH 7.5
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 7xpa
Q-score: 0.338
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC, Chen CJ
Nat Commun (2023) 14 pp. 545-545 [ DOI: doi:10.1038/s41467-023-36235-3 Pubmed: 36726015 ]
- Lake sinai virus 2 (Virus from Lake Sinai virus 2)
- Capsid protein alpha (57 kDa, Protein from Lake Sinai virus 2)
Cryo-EM structure of the T=4 lake sinai virus 2 virus-like capsid at pH 6.5
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 7xpb
Q-score: 0.288
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC, Chen CJ
Nat Commun (2023) 14 pp. 545-545 [ DOI: doi:10.1038/s41467-023-36235-3 Pubmed: 36726015 ]
- Lake sinai virus 2 (Virus from Lake Sinai virus 2)
- Capsid protein alpha (57 kDa, Protein from Lake Sinai virus 2)
Cryo-EM structure of the T=3 lake sinai virus 2 virus-like capsid at pH 6.5
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 7xpd
Q-score: 0.271
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC, Chen CJ
Nat Commun (2023) 14 pp. 545-545 [ DOI: doi:10.1038/s41467-023-36235-3 Pubmed: 36726015 ]
- Lake sinai virus 2 (Virus from Lake Sinai virus 2)
- Capsid protein alpha (57 kDa, Protein from Lake Sinai virus 2)
Cryo-EM structure of the T=4 lake sinai virus 2 virus-like capsid at pH 8.5
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7xpe
Q-score: 0.325
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC, Chen CJ
Nat Commun (2023) 14 pp. 545-545 [ DOI: doi:10.1038/s41467-023-36235-3 Pubmed: 36726015 ]
- Lake sinai virus 2 (Virus from Lake Sinai virus 2)
- Capsid protein alpha (57 kDa, Protein from Lake Sinai virus 2)
Cryo-EM structure of the T=3 lake sinai virus 2 virus-like capsid at pH 8.5
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 7xpf
Q-score: 0.351
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC, Chen CJ
Nat Commun (2023) 14 pp. 545-545 [ DOI: doi:10.1038/s41467-023-36235-3 Pubmed: 36726015 ]
- Lake sinai virus 2 (Virus from Lake Sinai virus 2)
- Capsid protein alpha (57 kDa, Protein from Lake Sinai virus 2)
Cryo-EM structure of the T=3 lake sinai virus 1 (delta-N48) virus-like capsid at pH 6.5
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7xpg
Q-score: 0.205
Chen NC, Wang CH, Yoshimura M, Yeh YQ, Guan HH, Chuankhayan P, Lin CC, Lin PJ, Huang YC, Wakatsuki S, Ho MC, Chen CJ
Nat Commun (2023) 14 pp. 545-545 [ DOI: doi:10.1038/s41467-023-36235-3 Pubmed: 36726015 ]
- Lake sinai virus 2 (Virus from Lake Sinai virus 2)
- Rna (5'-r(p*up*g)-3') (606 Da, RNA from Escherichia coli)
- Capsid protein alpha (62 kDa, Protein from Lake Sinai virus 1)