Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8eoa
Q-score: 0.343
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ DOI: doi:10.1016/j.str.2022.12.014 Pubmed: 36657440 ]
- Magnesium ion (24 Da, Ligand)
- Aryl-hydrocarbon-interacting protein-like 1 (40 kDa, Protein from Mus musculus)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Hsp90b/aipl1 complex (215 kDa, Complex from Homo sapiens)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8eob
Q-score: 0.516
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ DOI: doi:10.1016/j.str.2022.12.014 Pubmed: 36657440 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Hsp90b dimer in the closed amppnp bound state (174 kDa, Complex from Homo sapiens)
CryoEM Structure of NLRP3 NACHT domain in complex with G2394
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8etr
Q-score: 0.488
McBride C, Trzoss L, Povero D, Lazic M, Ambrus-Aikelin G, Santini A, Pranadinata R, Bain G, Stansfield R, Stafford JA, Veal J, Takahashi R, Ly J, Chen S, Liu L, Nespi M, Blake R, Katewa A, Kleinheinz T, Sujatha-Bhaskar S, Ramamoorthi N, Sims J, McKenzie B, Chen M, Ultsch M, Johnson M, Murray J, Ciferri C, Staben ST, Townsend MJ, Stivala CE
J Med Chem (2022) 65 pp. 14721-14739 [ DOI: doi:10.1021/acs.jmedchem.2c01250 Pubmed: 36279149 ]
- Nacht, lrr and pyd domains-containing protein 3 (63 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- (6s,8r)-n-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-6-(methylamino)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (431 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nlrp3 nacht domain (120 kDa, Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sjo
Q-score: 0.405
Gerhardy S, Ultsch M, Tang W, Green E, Holden JK, Li W, Estevez A, Arthur C, Tom I, Rohou A, Kirchhofer D
Nat Commun (2022) 13 pp. 5222-5222 [ DOI: doi:10.1038/s41467-022-32760-9 Pubmed: 36064790 ]
- Serine protease htra1 (25 kDa, Protein from Homo sapiens)
- Fab15h6.v4 heavy chain (26 kDa, Protein from Homo sapiens)
- Fab15h6.v4 light chain (25 kDa, Protein from Homo sapiens)
- Htra1pd/sa bound by fab15h6.v4 at loopa epitope (220 kDa, Complex from Homo sapiens)
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8dv1
Q-score: 0.415
Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech Jr TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA
Structure (2023) 31 pp. 253- [ DOI: doi:10.1016/j.str.2023.01.009 Pubmed: 36805129 ]
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 wuhan-hu-1-spike bound to linker variant of affinity matured ace2 mimetic cvd432 (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion,immunoglobulin gamma-1 heavy chain (110 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8dv2
Q-score: 0.394
Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech Jr TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA
Structure (2023) 31 pp. 253- [ DOI: doi:10.1016/j.str.2023.01.009 Pubmed: 36805129 ]
- Spike glycoprotein (Complex from Homo sapiens)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (113 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 wuhan-hu-1-spike bound to linker variant of affinity matured ace2 mimetic cvd293 (Complex from Severe acute respiratory syndrome coronavirus 2)
E1435Q Ycf1 mutant in inward-facing wide conformation
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7m69
Q-score: 0.318
Khandelwal NK, Millan CR, Zangari SI, Avila S, Williams D, Thaker TM, Tomasiak TM
Nat Commun (2022) 13 pp. 1278-1278 [ DOI: doi:10.1038/s41467-022-28811-w Pubmed: 35277487 ]
- Ycf1 (176 kDa, Complex from Saccharomyces cerevisiae S288C)
- Metal resistance protein ycf1 (176 kDa, Protein from Saccharomyces cerevisiae S288C)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7cth
Q-score: 0.421
Sharma A, Zhang X, Dejnirattisai W, Dai X, Gong D, Wongwiwat W, Duquerroy S, Rouvinski A, Vaney MC, Guardado-Calvo P, Haouz A, England P, Sun R, Zhou ZH, Mongkolsapaya J, Screaton GR, Rey FA
Cell (2021) 184 pp. 6052- [ DOI: doi:10.1016/j.cell.2021.11.010 Pubmed: 34852239 ]
- Core protein (54 kDa, Protein from Dengue virus 2)
- Core protein (8 kDa, Protein from Dengue virus 2)
- Single chain variable fragment (15 kDa, Protein from Homo sapiens)
- Dengue virus (Virus from Dengue virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Single chain variable fragment (15 kDa, Protein from Homo sapiens)
Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7lrd
Q-score: 0.434
Garvie CW, Wu X, Papanastasiou M, Lee S, Fuller J, Schnitzler GR, Horner SW, Baker A, Zhang T, Mullahoo JP, Westlake L, Hoyt SH, Toetzl M, Ranaghan MJ, de Waal L, McGaunn J, Kaplan B, Piccioni F, Yang X, Lange M, Tersteegen A, Raymond D, Lewis TA, Carr SA, Cherniack AD, Lemke CT, Meyerson M, Greulich H
Nat Commun (2021) 12 pp. 4375-4375 [ DOI: doi:10.1038/s41467-021-24495-w Pubmed: 34272366 ]
- Magnesium ion (24 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (4~{r})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{h}-pyridazin-6-one (305 Da, Ligand)
- Schlafen family member 12 (67 kDa, Protein from Homo sapiens)
- Slfn12-pde3a complex, consensus subset model (Complex from Homo sapiens)
- Cgmp-inhibited 3',5'-cyclic phosphodiesterase a (57 kDa, Protein from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7bl2
Q-score: 0.328
Nikolay R, Hilal T, Schmidt S, Qin B, Schwefel D, Vieira-Vieira CH, Mielke T, Burger J, Loerke J, Amikura K, Flugel T, Ueda T, Selbach M, Deuerling E, Spahn CMT
Mol Cell (2021) 81 pp. 1200-1215.e9 [ DOI: doi:10.1016/j.molcel.2021.02.006 Pubmed: 33639093 ]
- 50s ribosomal protein l11 (14 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l17 (14 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l18 (12 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l30 (6 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l14 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l20 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l15 (15 kDa, Protein from Escherichia coli (strain K12))
- 23s ribosomal rna (946 kDa, RNA from Escherichia coli (strain K12))
- 50s ribosomal protein l6 (18 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l4 (22 kDa, Protein from Escherichia coli (strain K12))
- Gtpase obge/cgta (43 kDa, Protein from Escherichia coli (strain K12))
- Magnesium ion (24 Da, Ligand)
- 5s ribosomal rna (38 kDa, RNA from Escherichia coli (strain K12))
- 50s ribosomal protein l21 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l28 (9 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l2 (29 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l19 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l22 (12 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l13 (16 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l27 (9 kDa, Protein from Escherichia coli (strain K12))
- Zinc ion (65 Da, Ligand)
- 50s ribosomal protein l9 (15 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l5 (20 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l24 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l32 (6 kDa, Protein from Escherichia coli (strain K12))
- Water (18 Da, Ligand)
- 50s ribosomal protein l33 (6 kDa, Protein from Escherichia coli (strain K12))
- Assembly intermediate complex 1 (1 MDa, Complex from Escherichia coli (strain K12))
- 50s ribosomal protein l29 (7 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l3 (22 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l34 (5 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l23 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l25 (10 kDa, Protein from Escherichia coli (strain K12))
- Ribosomal silencing factor rsfs (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l31 (7 kDa, Protein from Escherichia coli (strain K12))