Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- N-[3-(2,5-difluoro-4-{[(4m)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide (513 Da, Ligand)
- P97/vcp aaa+ atpase r155h mutant/nsc804515 (536 kDa, Complex from Homo sapiens)
CryoEM Structure of NLRP3 NACHT domain in complex with G2394
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8etr
Q-score: 0.488
McBride C, Trzoss L, Povero D, Lazic M, Ambrus-Aikelin G, Santini A, Pranadinata R, Bain G, Stansfield R, Stafford JA, Veal J, Takahashi R, Ly J, Chen S, Liu L, Nespi M, Blake R, Katewa A, Kleinheinz T, Sujatha-Bhaskar S, Ramamoorthi N, Sims J, McKenzie B, Chen M, Ultsch M, Johnson M, Murray J, Ciferri C, Staben ST, Townsend MJ, Stivala CE
J Med Chem (2022) 65 pp. 14721-14739 [ DOI: doi:10.1021/acs.jmedchem.2c01250 Pubmed: 36279149 ]
- Nacht, lrr and pyd domains-containing protein 3 (63 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- (6s,8r)-n-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]-6-(methylamino)-6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (431 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Nlrp3 nacht domain (120 kDa, Complex from Homo sapiens)
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8dv1
Q-score: 0.415
Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech Jr TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA
Structure (2023) 31 pp. 253- [ DOI: doi:10.1016/j.str.2023.01.009 Pubmed: 36805129 ]
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 wuhan-hu-1-spike bound to linker variant of affinity matured ace2 mimetic cvd432 (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion,immunoglobulin gamma-1 heavy chain (110 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8dv2
Q-score: 0.394
Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech Jr TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA
Structure (2023) 31 pp. 253- [ DOI: doi:10.1016/j.str.2023.01.009 Pubmed: 36805129 ]
- Spike glycoprotein (Complex from Homo sapiens)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (113 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (Complex)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 wuhan-hu-1-spike bound to linker variant of affinity matured ace2 mimetic cvd293 (Complex from Severe acute respiratory syndrome coronavirus 2)
80S ribosome from mouse bound to eEF2 (Class II)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ls1
Q-score: 0.374
Smith PR, Loerch S, Kunder N, Stanowick AD, Lou TF, Campbell ZT
Nat Commun (2021) 12 pp. 6789-6789 [ DOI: doi:10.1038/s41467-021-27160-4 Pubmed: 34815424 ]
- 40s ribosomal protein sa (32 kDa, Protein from Mouse)
- 60s ribosomal protein l26 (17 kDa, Protein from Mouse)
- 40s ribosomal protein s12 (14 kDa, Protein from Mouse)
- 40s ribosomal protein s26 (13 kDa, Protein from Mouse)
- Trna (24 kDa, RNA from Mus musculus)
- 40s ribosomal protein s7 (22 kDa, Protein from Mouse)
- Receptor of activated protein c kinase 1 (35 kDa, Protein from Mouse)
- 60s ribosomal protein l37 (11 kDa, Protein from Mouse)
- Isoform 3 of plasminogen activator inhibitor 1 rna-binding protein (42 kDa, Protein from Mouse)
- 60s ribosomal protein l10-like (24 kDa, Protein from Mouse)
- 60s ribosomal protein l11 (20 kDa, Protein from Mouse)
- 60s ribosomal protein l23 (14 kDa, Protein from Mouse)
- 40s ribosomal protein s17 (15 kDa, Protein from Mouse)
- 60s ribosomal protein l7a (30 kDa, Protein from Mouse)
- 5s rrna (38 kDa, RNA from Mus musculus)
- 40s ribosomal protein s2 (31 kDa, Protein from Mouse)
- 60s ribosomal protein l36a (12 kDa, Protein from Mouse)
- 60s ribosomal protein l34 (13 kDa, Protein from Mouse)
- 40s ribosomal protein s8 (24 kDa, Protein from Mouse)
- 60s ribosomal protein l7 (31 kDa, Protein from Mouse)
- 60s ribosomal protein l24 (17 kDa, Protein from Mouse)
- 40s ribosomal protein s3 (26 kDa, Protein from Mouse)
- 40s ribosomal protein s20 (13 kDa, Protein from Mouse)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l21 (18 kDa, Protein from Mouse)
- 60s ribosomal protein l39 (6 kDa, Protein from Mouse)
- 60s ribosomal protein l30 (12 kDa, Protein from Mouse)
- 28s rrna (1 MDa, RNA from Mus musculus)
- 60s ribosomal protein l19 (23 kDa, Protein from Mouse)
- 40s ribosomal protein s13 (17 kDa, Protein from Mouse)
- 40s ribosomal protein s9 (22 kDa, Protein from Mouse)
- 60s ribosomal protein l9 (21 kDa, Protein from Mouse)
- 40s ribosomal protein s16 (16 kDa, Protein from Mouse)
- 28s rrna (603 kDa, RNA from Mus musculus)
- 40s ribosomal protein s18 (17 kDa, Protein from Mouse)
- 40s ribosomal protein s24 (15 kDa, Protein from Mouse)
- 40s ribosomal protein s28 (7 kDa, Protein from Mouse)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l35 (14 kDa, Protein from Mouse)
- 40s ribosomal protein s14 (16 kDa, Protein from Mouse)
- 60s ribosomal protein l41 (3 kDa, Protein from Mouse)
- 60s ribosomal protein l27 (15 kDa, Protein from Mouse)
- 40s ribosomal protein s27-like (9 kDa, Protein from Mouse)
- 40s ribosomal protein s30 (14 kDa, Protein from Mouse)
- 40s ribosomal protein s5 (22 kDa, Protein from Mouse)
- 60s ribosomal protein l37a (10 kDa, Protein from Mouse)
- 40s ribosomal protein s10 (18 kDa, Protein from Mouse)
- 40s ribosomal protein s19 (16 kDa, Protein from Mouse)
- 60s ribosomal protein l12 (17 kDa, Protein from Mouse)
- 60s ribosomal protein l35a (12 kDa, Protein from Mouse)
- 60s ribosomal protein l14 (23 kDa, Protein from Mouse)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Mouse)
- 40s ribosomal protein s23 (15 kDa, Protein from Mouse)
- 60s ribosomal protein l36 (12 kDa, Protein from Mouse)
- 40s ribosomal protein s4, x isoform (29 kDa, Protein from Mouse)
- 40s ribosomal protein s6 (28 kDa, Protein from Mouse)
- Elongation factor 2 (95 kDa, Protein from Mouse)
- 60s ribosomal protein l4 (47 kDa, Protein from Mouse)
- Water (18 Da, Ligand)
- 60s ribosomal protein l27a (16 kDa, Protein from Mouse)
- 60s ribosomal protein l8 (28 kDa, Protein from Mouse)
- 60s ribosomal protein l28 (15 kDa, Protein from Mouse)
- 60s ribosomal protein l29 (17 kDa, Protein from Mouse)
- 60s ribosomal protein l3 (46 kDa, Protein from Mouse)
- 40s ribosomal protein s15a (14 kDa, Protein from Mouse)
- 60s ribosomal protein l23a (17 kDa, Protein from Mouse)
- 60s ribosomal protein l17 (21 kDa, Protein from Mouse)
- 40s ribosomal protein s11 (18 kDa, Protein from Mouse)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- 60s ribosomal protein l18 (21 kDa, Protein from Mouse)
- 60s ribosomal protein l22 (14 kDa, Protein from Mouse)
- 40s ribosomal protein s21 (9 kDa, Protein from Mouse)
- 60s ribosomal protein l10a (24 kDa, Protein from Mouse)
- 60s ribosomal protein l5 (34 kDa, Protein from Mouse)
- 80s ribosome from mous ebound to eef2 (4 MDa, Complex from Mus musculus)
- 40s ribosomal protein s29 (6 kDa, Protein from Mouse)
- 60s ribosomal protein l13a (23 kDa, Protein from Mouse)
- 60s ribosomal protein l13 (24 kDa, Protein from Mouse)
- Ubiquitin-40s ribosomal protein s27a (17 kDa, Protein from Mouse)
- 60s ribosomal protein l31 (14 kDa, Protein from Mouse)
- 60s ribosomal protein l6 (33 kDa, Protein from Mouse)
- 40s ribosomal protein s15 (17 kDa, Protein from Mouse)
- 60s ribosomal protein l32 (15 kDa, Protein from Mouse)
- 5.8s rrna (55 kDa, RNA from Mus musculus)
- 60s ribosomal protein l38 (8 kDa, Protein from Mouse)
- 40s ribosomal protein s3a (29 kDa, Protein from Mouse)
- 60s ribosomal protein l15 (24 kDa, Protein from Mouse)
- 40s ribosomal protein s25 (13 kDa, Protein from Mouse)
- 60s acidic ribosomal protein p0 (34 kDa, Protein from Mouse)
- 60s ribosomal protein l18a (20 kDa, Protein from Mouse)
Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7lrd
Q-score: 0.434
Garvie CW, Wu X, Papanastasiou M, Lee S, Fuller J, Schnitzler GR, Horner SW, Baker A, Zhang T, Mullahoo JP, Westlake L, Hoyt SH, Toetzl M, Ranaghan MJ, de Waal L, McGaunn J, Kaplan B, Piccioni F, Yang X, Lange M, Tersteegen A, Raymond D, Lewis TA, Carr SA, Cherniack AD, Lemke CT, Meyerson M, Greulich H
Nat Commun (2021) 12 pp. 4375-4375 [ DOI: doi:10.1038/s41467-021-24495-w Pubmed: 34272366 ]
- Magnesium ion (24 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (4~{r})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{h}-pyridazin-6-one (305 Da, Ligand)
- Schlafen family member 12 (67 kDa, Protein from Homo sapiens)
- Slfn12-pde3a complex, consensus subset model (Complex from Homo sapiens)
- Cgmp-inhibited 3',5'-cyclic phosphodiesterase a (57 kDa, Protein from Homo sapiens)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7bl2
Q-score: 0.328
Nikolay R, Hilal T, Schmidt S, Qin B, Schwefel D, Vieira-Vieira CH, Mielke T, Burger J, Loerke J, Amikura K, Flugel T, Ueda T, Selbach M, Deuerling E, Spahn CMT
Mol Cell (2021) 81 pp. 1200-1215.e9 [ DOI: doi:10.1016/j.molcel.2021.02.006 Pubmed: 33639093 ]
- 50s ribosomal protein l11 (14 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l17 (14 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l18 (12 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l30 (6 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l14 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l20 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l15 (15 kDa, Protein from Escherichia coli (strain K12))
- 23s ribosomal rna (946 kDa, RNA from Escherichia coli (strain K12))
- 50s ribosomal protein l6 (18 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l4 (22 kDa, Protein from Escherichia coli (strain K12))
- Gtpase obge/cgta (43 kDa, Protein from Escherichia coli (strain K12))
- Magnesium ion (24 Da, Ligand)
- 5s ribosomal rna (38 kDa, RNA from Escherichia coli (strain K12))
- 50s ribosomal protein l21 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l28 (9 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l2 (29 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l19 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l22 (12 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l13 (16 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l27 (9 kDa, Protein from Escherichia coli (strain K12))
- Zinc ion (65 Da, Ligand)
- 50s ribosomal protein l9 (15 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l5 (20 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l24 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l32 (6 kDa, Protein from Escherichia coli (strain K12))
- Water (18 Da, Ligand)
- 50s ribosomal protein l33 (6 kDa, Protein from Escherichia coli (strain K12))
- Assembly intermediate complex 1 (1 MDa, Complex from Escherichia coli (strain K12))
- 50s ribosomal protein l29 (7 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l3 (22 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l34 (5 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l23 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l25 (10 kDa, Protein from Escherichia coli (strain K12))
- Ribosomal silencing factor rsfs (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l31 (7 kDa, Protein from Escherichia coli (strain K12))
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7bl3
Q-score: 0.362
Nikolay R, Hilal T, Schmidt S, Qin B, Schwefel D, Vieira-Vieira CH, Mielke T, Burger J, Loerke J, Amikura K, Flugel T, Ueda T, Selbach M, Deuerling E, Spahn CMT
Mol Cell (2021) 81 pp. 1200-1215.e9 [ DOI: doi:10.1016/j.molcel.2021.02.006 Pubmed: 33639093 ]
- 50s ribosomal protein l11 (14 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l17 (14 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l18 (12 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l30 (6 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l14 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l20 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l15 (15 kDa, Protein from Escherichia coli (strain K12))
- 23s ribosomal rna (946 kDa, RNA from Escherichia coli (strain K12))
- 50s ribosomal protein l6 (18 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l4 (22 kDa, Protein from Escherichia coli (strain K12))
- Gtpase obge/cgta (43 kDa, Protein from Escherichia coli (strain K12))
- Magnesium ion (24 Da, Ligand)
- 50s ribosomal protein l21 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l28 (9 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l2 (29 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l19 (13 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l22 (12 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l13 (16 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l27 (9 kDa, Protein from Escherichia coli (strain K12))
- Zinc ion (65 Da, Ligand)
- 50s ribosomal protein l9 (15 kDa, Protein from Escherichia coli (strain K12))
- Ribosomal pre-50s assembly intermediate state 2 (1 MDa, Complex from Escherichia coli (strain K12))
- 5s ribosomal rna (38 kDa, RNA from Escherichia coli (strain K12))
- 50s ribosomal protein l5 (20 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l24 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l32 (6 kDa, Protein from Escherichia coli (strain K12))
- Water (18 Da, Ligand)
- 50s ribosomal protein l33 (6 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l34 (5 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l29 (7 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l3 (22 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l23 (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l25 (10 kDa, Protein from Escherichia coli (strain K12))
- Ribosomal silencing factor rsfs (11 kDa, Protein from Escherichia coli (strain K12))
- 50s ribosomal protein l31 (7 kDa, Protein from Escherichia coli (strain K12))
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7bl5
Q-score: 0.363
Nikolay R, Hilal T, Schmidt S, Qin B, Schwefel D, Vieira-Vieira CH, Mielke T, Burger J, Loerke J, Amikura K, Flugel T, Ueda T, Selbach M, Deuerling E, Spahn CMT
Mol Cell (2021) 81 pp. 1200-1215.e9 [ DOI: doi:10.1016/j.molcel.2021.02.006 Pubmed: 33639093 ]
- 50s ribosomal protein l29 (7 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l6 (18 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l23 (11 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l14 (13 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l18 (12 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Gtpase obge/cgta (43 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l16 (15 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l17 (14 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l15 (15 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l30 (6 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- 50s ribosomal protein l5 (20 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l32 (6 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l3 (22 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l19 (13 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l11 (14 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l31 (7 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l33 (6 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Ribosomal silencing factor rsfs (11 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l4 (22 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 5s ribosomal rna (38 kDa, RNA from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l20 (13 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l25 (10 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l24 (11 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Assembly intermediate complex 3 (1 MDa, Complex from Escherichia coli str. K-12 substr. MG1655)
- Zinc ion (65 Da, Ligand)
- 50s ribosomal protein l34 (5 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l10 (17 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l22 (12 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Water (18 Da, Ligand)
- 50s ribosomal protein l27 (9 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l2 (29 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Upf0307 protein yjga (21 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l9 (15 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l13 (16 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l21 (11 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- Ribosomal large subunit pseudouridine synthase d (37 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 50s ribosomal protein l28 (9 kDa, Protein from Escherichia coli str. K-12 substr. MG1655)
- 23s ribosomal rna (946 kDa, RNA from Escherichia coli str. K-12 substr. MG1655)
Structure of human TRPA1 in complex with inhibitor GDC-0334
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6wj5
Q-score: 0.471
Balestrini A, Joseph V, Dourado M, Reese RM, Shields SD, Rouge L, Bravo DD, Chernov-Rogan T, Austin CD, Chen H, Wang L, Villemure E, Shore DGM, Verma VA, Hu B, Chen Y, Leong L, Bjornson C, Hotzel K, Gogineni A, Lee WP, Suto E, Wu X, Liu J, Zhang J, Gandham V, Wang J, Payandeh J, Ciferri C, Estevez A, Arthur CP, Kortmann J, Wong RL, Heredia JE, Doerr J, Jung M, Vander Heiden JA, Roose-Girma M, Tam L, Barck KH, Carano RAD, Ding HT, Brillantes B, Tam C, Yang X, Gao SS, Ly JQ, Liu L, Chen L, Liederer BM, Lin JH, Magnuson S, Chen J, Hackos DH, Elstrott J, Rohou A, Safina BS, Volgraf M, Bauer RN, Riol-Blanco L
J Exp Med (2021) 218 [ DOI: doi:10.1084/jem.20201637 Pubmed: 33620419 ]
- Transient receptor potential cation channel subfamily a member 1 (72 kDa, Protein from Homo sapiens)
- (4r,5s)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-n-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-l-prolinamide (609 Da, Ligand)
- Trpa1 bound by inhibitor gdc-0334 (Complex from Homo sapiens)