D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 8e92
Q-score: 0.397
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H
Mol Cell (2022) 82 pp. 4548- [ DOI: doi:10.1016/j.molcel.2022.10.008 Pubmed: 36309015 ]
- Glutamate receptor ionotropic, nmda 2c (96 kDa, Protein from Homo sapiens)
- Hetero-tetrameric glun1a-glun2c nmda receptors (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8e93
Q-score: 0.443
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H
Mol Cell (2022) 82 pp. 4548- [ DOI: doi:10.1016/j.molcel.2022.10.008 Pubmed: 36309015 ]
- Glutamate receptor ionotropic, nmda 2c (96 kDa, Protein from Homo sapiens)
- Hetero-tetrameric glun1a-glun2c nmda receptors (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8e94
Q-score: 0.47
Chou TH, Kang H, Simorowski N, Traynelis SF, Furukawa H
Mol Cell (2022) 82 pp. 4548- [ DOI: doi:10.1016/j.molcel.2022.10.008 Pubmed: 36309015 ]
- Methyl 4-[(2~{r})-3-ethanoyl-1-[2-(2-methyl-1~{h}-indol-3-yl)ethyl]-4-oxidanyl-5-oxidanylidene-2~{h}-pyrrol-2-yl]benzoate (432 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2c (96 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Hetero-tetrameric glun1a-glun2c nmda receptors (Complex from Homo sapiens)
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to linker variant of affinity matured ACE2 mimetic CVD432
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8dv1
Q-score: 0.415
Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech Jr TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA
Structure (2023) 31 pp. 253- [ DOI: doi:10.1016/j.str.2023.01.009 Pubmed: 36805129 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion,immunoglobulin gamma-1 heavy chain (110 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (Complex from Homo sapiens)
- Sars-cov-2 wuhan-hu-1-spike bound to linker variant of affinity matured ace2 mimetic cvd432 (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Wuhan-hu-1-Spike-RBD bound to computationally engineered ACE2 mimetic CVD293
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8dv2
Q-score: 0.394
Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech Jr TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA
Structure (2023) 31 pp. 253- [ DOI: doi:10.1016/j.str.2023.01.009 Pubmed: 36805129 ]
- Spike glycoprotein (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (113 kDa, Protein from Homo sapiens)
- Sars-cov-2 wuhan-hu-1-spike bound to linker variant of affinity matured ace2 mimetic cvd293 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2,immunoglobulin gamma-1 heavy chain fusion (Complex)
S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7sac
Q-score: 0.419
Chou TH, Epstein M, Michalski K, Fine E, Biggin PC, Furukawa H
Nat Struct Mol Biol (2022) 29 pp. 507-518 [ Pubmed: 35637422 DOI: doi:10.1038/s41594-022-00772-0 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2~{s})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (237 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)
- Hetero-tetrameric glun1a-glun2b nmda receptors (Complex from Rattus norvegicus)
Memantine-bound GluN1a-GluN2B NMDA receptors
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 7sad
Q-score: 0.376
Chou TH, Epstein M, Michalski K, Fine E, Biggin PC, Furukawa H
Nat Struct Mol Biol (2022) 29 pp. 507-518 [ Pubmed: 35637422 DOI: doi:10.1038/s41594-022-00772-0 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Memantine (179 Da, Ligand)
- Hetero-tetrameric glun1a-glun2b nmda receptors (Complex from Rattus norvegicus)
GluN1b-GluN2B NMDA receptor in non-active 2 conformation at 4 angstrom resolution
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 6whr
Q-score: 0.411
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)
GluN1b-GluN2B NMDA receptor in complex with SDZ 220-040 and L689,560, class 1
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 6whu
Q-score: 0.42
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2s)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid (420 Da, Ligand)
- (2r,4s)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (380 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 6wi1
Q-score: 0.404
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- Ionotropic glutamate receptor , nmda receptor glun1b (97 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ionotropic glutamate receptor , nmda receptor glun2b (98 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)