Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8cyi
Q-score: 0.451
Zhou W, Yadav GP, Yang X, Qin F, Li C, Jiang QX
Commun Biol (2022) 5 pp. 1054-1054 [ Pubmed: 36192627 DOI: doi:10.1038/s42003-022-03991-9 ]
- Protein arginine n-methyltransferase 5 (72 kDa, Protein from Homo sapiens)
- N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1h-carbazole-6-carboxamide (414 Da, Ligand)
- 5'-deoxy-5'-methylthioadenosine (297 Da, Ligand)
- Complex of prmt5 and mep50 in the presence of mta and a novel inhibitor (11-2f) (440 kDa, Complex from Homo sapiens)
- Methylosome protein 50 (33 kDa, Protein from Homo sapiens)
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7lwd
Q-score: 0.466
Plenge P, Yang D, Salomon K, Laursen L, Kalenderoglou IE, Newman AH, Gouaux E, Coleman JA, Loland CJ
Nat Commun (2021) 12 pp. 5063-5063 [ Pubmed: 34417466 DOI: doi:10.1038/s41467-021-25363-3 ]
- Heavy chain antibody fragment (12 kDa, Protein from Mus musculus)
- 8b6 antibody (Complex from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- Light chain antibody fragment (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-{4-[4-(5-cyano-1h-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide (441 Da, Ligand)
- Serotonin transporter 8b6 fab complex (105 kDa, Complex)
- 3-(5h-dibenzo[b,f]azepin-5-yl)-n,n-dimethylpropan-1-amine (280 Da, Ligand)
- Sodium-dependent serotonin transporter (61 kDa, Protein from Homo sapiens)
Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7lrd
Q-score: 0.434
Garvie CW, Wu X, Papanastasiou M, Lee S, Fuller J, Schnitzler GR, Horner SW, Baker A, Zhang T, Mullahoo JP, Westlake L, Hoyt SH, Toetzl M, Ranaghan MJ, de Waal L, McGaunn J, Kaplan B, Piccioni F, Yang X, Lange M, Tersteegen A, Raymond D, Lewis TA, Carr SA, Cherniack AD, Lemke CT, Meyerson M, Greulich H
Nat Commun (2021) 12 pp. 4375-4375 [ DOI: doi:10.1038/s41467-021-24495-w Pubmed: 34272366 ]
- Magnesium ion (24 Da, Ligand)
- Manganese (ii) ion (54 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- (4~{r})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{h}-pyridazin-6-one (305 Da, Ligand)
- Schlafen family member 12 (67 kDa, Protein from Homo sapiens)
- Slfn12-pde3a complex, consensus subset model (Complex from Homo sapiens)
- Cgmp-inhibited 3',5'-cyclic phosphodiesterase a (57 kDa, Protein from Homo sapiens)
Human AAA+ ATPase VCP mutant - T76A, AMP-PNP-bound form, Conformation I
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7bpa
Q-score: 0.512
Zhu K, Cai Y, Si X, Ye Z, Gao Y, Liu C, Wang R, Ma Z, Zhu H, Zhang L, Li S, Zhang H, Yue J
Cell Death Differ. (2022) [ Pubmed: 35430615 DOI: doi:10.1038/s41418-022-01000-4 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Transitional endoplasmic reticulum atpase, vcp. (97 MDa, Complex from Homo sapiens)
Structure of human TRPA1 in complex with inhibitor GDC-0334
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6wj5
Q-score: 0.471
Balestrini A, Joseph V, Dourado M, Reese RM, Shields SD, Rouge L, Bravo DD, Chernov-Rogan T, Austin CD, Chen H, Wang L, Villemure E, Shore DGM, Verma VA, Hu B, Chen Y, Leong L, Bjornson C, Hotzel K, Gogineni A, Lee WP, Suto E, Wu X, Liu J, Zhang J, Gandham V, Wang J, Payandeh J, Ciferri C, Estevez A, Arthur CP, Kortmann J, Wong RL, Heredia JE, Doerr J, Jung M, Vander Heiden JA, Roose-Girma M, Tam L, Barck KH, Carano RAD, Ding HT, Brillantes B, Tam C, Yang X, Gao SS, Ly JQ, Liu L, Chen L, Liederer BM, Lin JH, Magnuson S, Chen J, Hackos DH, Elstrott J, Rohou A, Safina BS, Volgraf M, Bauer RN, Riol-Blanco L
J Exp Med (2021) 218 [ DOI: doi:10.1084/jem.20201637 Pubmed: 33620419 ]
- Transient receptor potential cation channel subfamily a member 1 (72 kDa, Protein from Homo sapiens)
- (4r,5s)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-n-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-l-prolinamide (609 Da, Ligand)
- Trpa1 bound by inhibitor gdc-0334 (Complex from Homo sapiens)
BatAAV-10HB - genome-containing particles
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 6wft
Q-score: 0.575
Mietzsch M, Li Y, Kurian J, Smith JK, Chipman P, McKenna R, Yang L, Agbandje-McKenna M
J Struct Biol (2020) 211 pp. 107547-107547 [ DOI: doi:10.1016/j.jsb.2020.107547 Pubmed: 32522552 ]
- Vp1 capsid (57 kDa, Protein from Bat adeno-associated virus)
- Adeno-associated virus (Virus from Adeno-associated virus)
- 2'-deoxyadenosine-5'-monophosphate (331 Da, Ligand)
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 6wfu
Q-score: 0.574
Mietzsch M, Li Y, Kurian J, Smith JK, Chipman P, McKenna R, Yang L, Agbandje-McKenna M
J Struct Biol (2020) 211 pp. 107547-107547 [ DOI: doi:10.1016/j.jsb.2020.107547 Pubmed: 32522552 ]
- Vp1 capsid (57 kDa, Protein from Bat adeno-associated virus)
- Adeno-associated virus (Virus from Adeno-associated virus)
Cryo-EM structure of the wild-type human serotonin transporter complexed with paroxetine and 8B6 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6vrh
Q-score: 0.454
Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux E
eLife (2020) 9 [ Pubmed: 32618269 DOI: doi:10.7554/eLife.56427 ]
- 8b6 antibody (Complex from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- 8b6 antibody, heavy chain (23 kDa, Protein from Mus musculus)
- Serotonin transporter 8b6 fab complex (105 kDa, Complex)
- Paroxetine (329 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 8b6 antibody, light chain (23 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (70 kDa, Protein from Homo sapiens)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6vrl
Q-score: 0.365
Coleman JA, Navratna V, Antermite D, Yang D, Bull JA, Gouaux E
eLife (2020) 9 [ Pubmed: 32618269 DOI: doi:10.7554/eLife.56427 ]
- 8b6 antibody (Complex from Mus musculus)
- Serotonin transporter (Complex from Homo sapiens)
- 8b6 antibody, heavy chain (23 kDa, Protein from Mus musculus)
- Serotonin transporter 8b6 fab complex (105 kDa, Complex)
- 8b6 antibody, light chain (23 kDa, Protein from Mus musculus)
- Sodium-dependent serotonin transporter (70 kDa, Protein from Homo sapiens)
- I-paroxetine (437 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6v3k
Q-score: 0.503
Passos DO, Li M, Jozwik IK, Zhao XZ, Santos-Martins D, Yang R, Smith SJ, Jeon Y, Forli S, Hughes SH, Burke Jr TR, Craigie R, Lyumkis D
Science (2020) 367 pp. 810-814 [ DOI: doi:10.1126/science.aay8015 Pubmed: 32001521 ]
- Magnesium ion (24 Da, Ligand)
- Assembly of hiv integrase and viral dna (400 kDa, Complex from Human immunodeficiency virus 1)
- 4-azanyl-n-[[2,4-bis(fluoranyl)phenyl]methyl]-1-oxidanyl-2-oxidanylidene-6-(5-oxidanylpentyl)-1,8-naphthyridine-3-carboxamide (432 Da, Ligand)
- Chimeric sso7d and hiv-1 integrase (42 kDa, Protein from Human immunodeficiency virus 1)
- Zinc ion (65 Da, Ligand)
- Viral dna transferred strand (7 kDa, DNA from Human immunodeficiency virus 1)
- Viral dna non-transferred strand (8 kDa, DNA from Human immunodeficiency virus 1)