Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- N-[3-(2,5-difluoro-4-{[(4m)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide (513 Da, Ligand)
- P97/vcp aaa+ atpase r155h mutant/nsc804515 (536 kDa, Complex from Homo sapiens)
ATP-1 state of Bcs1 (C7 symmetrized)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8t5u
Q-score: 0.449
Zhan J, Zeher A, Huang R, Tang WK, Jenkins LM, Xia D
Nat Commun (2024) 15 pp. 4655-4655 [ DOI: doi:10.1038/s41467-024-49029-y Pubmed: 38821922 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Heptameric bcs1 in uniform atp-bound state captured during active atpase cycle (340 kDa, Complex from Mus musculus)
- Mitochondrial chaperone bcs1 (48 kDa, Protein from Mus musculus)
ATP-1 state of Bcs1 (unsymmetrized)
Resolution: 3.77 Å
EM Method: Single-particle
Fitted PDBs: 8ti0
Q-score: 0.312
Zhan J, Zeher A, Huang R, Tang WK, Jenkins LM, Xia D
Nat Commun (2024) 15 pp. 4655-4655 [ DOI: doi:10.1038/s41467-024-49029-y Pubmed: 38821922 ]
- Heptameric bcs1 in uniform atp-bound state captured in active atpase cycle (340 kDa, Complex from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Mitochondrial chaperone bcs1 (48 kDa, Protein from Mus musculus)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8fak
Q-score: 0.431
Duckworth AT, Ducos PL, McMillan SD, Satyshur KA, Blumenthal KH, Deorio HR, Larson JA, Sandler SJ, Grant T, Keck JL
Nat Commun (2023) 14 pp. 2725-2725 [ DOI: doi:10.1038/s41467-023-38144-x Pubmed: 37169801 ]
- Complex of pria, prib, and replication fork (134 kDa, Complex from Escherichia coli)
- Dna (5'-d(p*cp*gp*gp*ap*tp*ap*ap*gp*gp*gp*cp*tp*gp*ap*gp*cp*ap*cp*gp*cp*cp*gp*a)-3') (12 kDa, DNA from synthetic construct)
- Dna (5'-d(p*tp*cp*gp*gp*cp*gp*tp*gp*cp*tp*c)-3') (4 kDa, DNA from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Primosomal replication protein n (11 kDa, Protein from Escherichia coli (strain K12))
- Primosomal protein n' (81 kDa, Protein from Escherichia coli (strain K12))
- Dna (5'-d(p*cp*ap*gp*ap*cp*tp*cp*ap*tp*tp*tp*ap*gp*cp*cp*cp*tp*tp*ap*tp*cp*cp*g)-3') (12 kDa, DNA from synthetic construct)
Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7z3n
Q-score: 0.412
Kisonaite M, Wild K, Lapouge K, Gese GV, Kellner N, Hurt E, Sinning I
Nat Struct Mol Biol (2023) 30 pp. 670-677 [ DOI: doi:10.1038/s41594-023-00973-1 Pubmed: 37081320 ]
- Putative heat shock protein (62 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l20 (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s21-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s10-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l26-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l36 (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l10-like protein (25 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s6 (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l37 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s9-like protein (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l7-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s23-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l12-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l30-like protein (11 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s7 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s13-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l2-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s20-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s26 (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El24 (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ul6 (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s8 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s16-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s1 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosome associated protein (51 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l15 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l3-like protein (44 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s19-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l25-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s12 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Nascent chain (2 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s2-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l44-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s30 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Zinc ion (65 Da, Ligand)
- Dolichyl-diphosphooligosaccharide--protein glycotransferase (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s28-like protein (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s15-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l34-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El38 (9 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative guanine nucleotide-binding protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l5-like protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l19 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s17-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s acidic ribosomal protein p0 (33 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s5-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s3-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l43-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5s rrna (38 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s24 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l33-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Habp4_pai-rbp1 domain-containing protein (32 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l28-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s11-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l29 (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Chaetomium thermophilum rac on 80s ribosome (Complex from Chaetomium thermophilum var. thermophilum DSM 1495)
- 60s ribosomal protein l41-a (3 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l23-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l18-like protein (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein el39 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Putative ribosomal protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l8 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l27 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l17-like protein (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l32-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l4-like protein (39 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein s27-like protein (8 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s4 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l21-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s25 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5.8s rrna (50 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l16-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 26s rrna (1 MDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s27a-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l13 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 18s rrna (578 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein us14 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s0 (31 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l6 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7z3o
Q-score: 0.462
Kisonaite M, Wild K, Lapouge K, Gese GV, Kellner N, Hurt E, Sinning I
Nat Struct Mol Biol (2023) 30 pp. 670-677 [ DOI: doi:10.1038/s41594-023-00973-1 Pubmed: 37081320 ]
- Putative heat shock protein (62 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l20 (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s21-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s10-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l26-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l36 (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l10-like protein (25 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s6 (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l37 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s9-like protein (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l7-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s23-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l12-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l30-like protein (11 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s7 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s13-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l2-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s20-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s26 (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El24 (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ul6 (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s8 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s16-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s1 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosome associated protein (51 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l15 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l3-like protein (44 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s19-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l25-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s12 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Nascent chain (2 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s2-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l44-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s30 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Zinc ion (65 Da, Ligand)
- Dolichyl-diphosphooligosaccharide--protein glycotransferase (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s28-like protein (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s15-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l34-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El38 (9 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative guanine nucleotide-binding protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l5-like protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l19 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s17-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s acidic ribosomal protein p0 (33 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s5-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s3-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l43-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5s rrna (38 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s24 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l33-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Habp4_pai-rbp1 domain-containing protein (32 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l28-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s11-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l29 (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Chaetomium thermophilum rac on 80s ribosome (Complex from Chaetomium thermophilum var. thermophilum DSM 1495)
- 60s ribosomal protein l41-a (3 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l23-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l18-like protein (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein el39 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Putative ribosomal protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l8 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l27 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l17-like protein (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l32-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l4-like protein (39 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein s27-like protein (8 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s4 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l21-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s25 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5.8s rrna (50 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l16-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 26s rrna (1 MDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s27a-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l13 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 18s rrna (578 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein us14 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s0 (31 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l6 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8cyi
Q-score: 0.451
Zhou W, Yadav GP, Yang X, Qin F, Li C, Jiang QX
Commun Biol (2022) 5 pp. 1054-1054 [ Pubmed: 36192627 DOI: doi:10.1038/s42003-022-03991-9 ]
- Protein arginine n-methyltransferase 5 (72 kDa, Protein from Homo sapiens)
- N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1h-carbazole-6-carboxamide (414 Da, Ligand)
- 5'-deoxy-5'-methylthioadenosine (297 Da, Ligand)
- Complex of prmt5 and mep50 in the presence of mta and a novel inhibitor (11-2f) (440 kDa, Complex from Homo sapiens)
- Methylosome protein 50 (33 kDa, Protein from Homo sapiens)
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-9296
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8f0s
Q-score: 0.614
Kschonsak M, Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J, Ciferri C, Tellis JC
eLife (2023) 12 [ DOI: doi:10.7554/eLife.84151 Pubmed: 36975198 ]
- 5-chloro-4-(cyclopentylmethoxy)-n-(4-{[(1s,2s)-2-(dimethylamino)cyclohexyl]amino}-2-fluorobenzene-1-sulfonyl)-2-fluorobenzamide (570 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Vsd4-nav1.7-navpas channel chimera bound to the hybrid inhibitor gne-9296 (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Sodium channel protein pafpc1,sodium channel protein type 9 subunit alpha chimera (184 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Beta-diguetoxin-dc1a (8 kDa, Protein from Diguetia canities)
Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8eoa
Q-score: 0.343
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ DOI: doi:10.1016/j.str.2022.12.014 Pubmed: 36657440 ]
- Magnesium ion (24 Da, Ligand)
- Aryl-hydrocarbon-interacting protein-like 1 (40 kDa, Protein from Mus musculus)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Hsp90b/aipl1 complex (215 kDa, Complex from Homo sapiens)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8eob
Q-score: 0.516
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ DOI: doi:10.1016/j.str.2022.12.014 Pubmed: 36657440 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Hsp90b dimer in the closed amppnp bound state (174 kDa, Complex from Homo sapiens)