Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- N-[3-(2,5-difluoro-4-{[(4m)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide (513 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- P97/vcp aaa+ atpase r155h mutant/nsc804515 (536 kDa, Complex from Homo sapiens)
Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8eob
Q-score: 0.516
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ Pubmed: 36657440 DOI: doi:10.1016/j.str.2022.12.014 ]
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Hsp90b dimer in the closed amppnp bound state (174 kDa, Complex from Homo sapiens)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7thj
Q-score: 0.423
Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch BA
eLife (2022) 11 [ Pubmed: 35179493 DOI: doi:10.7554/eLife.74175 ]
- Rfc5 (Protein from Saccharomyces cerevisiae)
- Pcna (Protein from Saccharomyces cerevisiae)
- Replication factor c (rfc), the eukaryotic clamp loader (336 kDa, Complex from Saccharomyces cerevisiae)
- Rfc1 (Protein from Saccharomyces cerevisiae)
- Rfc3 (RNA from Saccharomyces cerevisiae)
- Rfc4 (Protein from Saccharomyces cerevisiae)
- Rfc2 (Protein from Saccharomyces cerevisiae)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7tic
Q-score: 0.395
Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch PhD BA
eLife (2022) 11 [ Pubmed: 35179493 DOI: doi:10.7554/eLife.74175 ]
- Rfc5 (Protein from Saccharomyces cerevisiae)
- Pcna (Protein from Saccharomyces cerevisiae)
- Replication factor c (rfc), the eukaryotic clamp loader (336 kDa, Complex from Saccharomyces cerevisiae)
- Rfc1 (Protein from Saccharomyces cerevisiae)
- Rfc3 (Protein from Saccharomyces cerevisiae)
- Rfc4 (Protein from Saccharomyces cerevisiae)
- Rfc2 (Protein from Saccharomyces cerevisiae)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7thv
Q-score: 0.406
Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch PhD BA
eLife (2022) 11 [ Pubmed: 35179493 DOI: doi:10.7554/eLife.74175 ]
- Pcna (Protein from Saccharomyces cerevisiae)
- Replication factor c (rfc), the eukaryotic clamp loader (336 kDa, Complex from Saccharomyces cerevisiae)
- Rfc1 (Protein from Saccharomyces cerevisiae)
- Rfc5 (RNA from Saccharomyces cerevisiae)
- Rfc3 (Protein from Saccharomyces cerevisiae)
- Rfc4 (Protein from Saccharomyces cerevisiae)
- Rfc2 (Protein from Saccharomyces cerevisiae)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7tku
Q-score: 0.405
Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch PhD BA
eLife (2022) 11 [ Pubmed: 35179493 DOI: doi:10.7554/eLife.74175 ]
- Rfc5 (Protein from Saccharomyces cerevisiae)
- Pcna (Protein from Saccharomyces cerevisiae)
- Rfc1 (Protein from Saccharomyces cerevisiae)
- Rfc3 (Protein from Saccharomyces cerevisiae)
- Rfc4 (Protein from Saccharomyces cerevisiae)
- Rfc2 (Protein from Saccharomyces cerevisiae)
- Structure of the yeast clamp loader (replication factor c rfc) bound to the open sliding clamp (proliferating cell nuclear antigen pcna) (336 kDa, Complex from Saccharomyces cerevisiae)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7tib
Q-score: 0.452
Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch PhD BA
eLife (2022) 11 [ Pubmed: 35179493 DOI: doi:10.7554/eLife.74175 ]
- Template (DNA from Saccharomyces cerevisiae)
- Replication factor c (rfc) bound to the open sliding clamp proliferating cell nuclear antigen (pcna) (336 kDa, Complex from Saccharomyces cerevisiae)
- Rfc5 (Protein from Saccharomyces cerevisiae)
- Pcna (Protein from Saccharomyces cerevisiae)
- Rfc1 (Protein from Saccharomyces cerevisiae)
- Primer (DNA from Saccharomyces cerevisiae)
- Rfc3 (Protein from Saccharomyces cerevisiae)
- Rfc4 (Protein from Saccharomyces cerevisiae)
- Rfc2 (Protein from Saccharomyces cerevisiae)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7tid
Q-score: 0.463
Gaubitz C, Liu X, Pajak J, Stone NP, Hayes JA, Demo G, Kelch PhD BA
eLife (2022) 11 [ Pubmed: 35179493 DOI: doi:10.7554/eLife.74175 ]
- Template (DNA from Saccharomyces cerevisiae)
- Replication factor c (rfc) bound to the open sliding clamp proliferating cell nuclear antigen (pcna) (336 kDa, Complex from Saccharomyces cerevisiae)
- Rfc5 (Protein from Saccharomyces cerevisiae)
- Pcna (Protein from Saccharomyces cerevisiae)
- Rfc1 (Protein from Saccharomyces cerevisiae)
- Primer (DNA from Saccharomyces cerevisiae)
- Rfc3 (Protein from Saccharomyces cerevisiae)
- Rfc4 (Protein from Saccharomyces cerevisiae)
- Rfc2 (Protein from Saccharomyces cerevisiae)
Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7rmg
Q-score: 0.532
Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A
Nat Chem Biol (2022) 18 pp. 109-115 [ Pubmed: 34711980 DOI: doi:10.1038/s41589-021-00890-8 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1/gamma-2 (Complex from Homo sapiens)
- Substance-p receptor (Complex from Homo sapiens)
- Substance p (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s)/g(q) subunit alpha hybrid (Complex from Homo sapiens)
- Substance p (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, with certain residues mutated to match guanine nucleotide-binding protein g(q) subunit (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Substance-p receptor (47 kDa, Protein from Homo sapiens)
- Substance p bound to neurokinin 1 receptor-minigs/q70 complex (Complex)