Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- N-[3-(2,5-difluoro-4-{[(4m)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide (513 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- P97/vcp aaa+ atpase r155h mutant/nsc804515 (536 kDa, Complex from Homo sapiens)
Cryo-EM map of zebrafish cardiac F-actin
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8ord
Q-score: 0.415
Bradshaw M, Squire JM, Morris E, Atkinson G, Richardson R, Lees J, Caputo M, Bigotti GM, Paul DM
J.Muscle Res.Cell.Motil. (2023) 44 pp. 179-192 [ DOI: doi:10.1007/s10974-023-09653-5 Pubmed: 37480427 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Actin, alpha 1b, skeletal muscle (42 kDa, Protein from Danio rerio)
- Phosphate ion (94 Da, Ligand)
- Cardiac f-actin (Complex from Danio rerio)
Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7z3n
Q-score: 0.412
Kisonaite M, Wild K, Lapouge K, Gese GV, Kellner N, Hurt E, Sinning I
Nat Struct Mol Biol (2023) 30 pp. 670-677 [ Pubmed: 37081320 DOI: doi:10.1038/s41594-023-00973-1 ]
- 60s ribosomal protein l33-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s26 (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l20 (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Dolichyl-diphosphooligosaccharide--protein glycotransferase (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s7 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l36 (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l19 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s6 (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s16-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s4 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s acidic ribosomal protein p0 (33 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l28-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l41-a (3 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l23-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein s27-like protein (8 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l44-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s2-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein us14 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s27a-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 26s rrna (1 MDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s21-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l12-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l43-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s28-like protein (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s12 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s30 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s9-like protein (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l21-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El38 (9 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El24 (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s17-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l17-like protein (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l5-like protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative heat shock protein (62 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s19-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chaetomium thermophilum rac on 80s ribosome (Complex from Chaetomium thermophilum var. thermophilum DSM 1495)
- 40s ribosomal protein s3-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l26-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l25-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l13 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s5-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s10-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosome associated protein (51 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ul6 (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l27 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s15-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l30-like protein (11 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l3-like protein (44 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l32-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative guanine nucleotide-binding protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l18-like protein (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s23-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l6 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s25 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l10-like protein (25 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s11-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s20-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l4-like protein (39 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l37 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Magnesium ion (24 Da, Ligand)
- Nascent chain (2 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5s rrna (38 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein el39 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l15 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l34-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s0 (31 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s8 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l29 (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l16-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l7-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s1 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5.8s rrna (50 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l8 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l2-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s13-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Habp4_pai-rbp1 domain-containing protein (32 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 18s rrna (578 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s24 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7z3o
Q-score: 0.462
Kisonaite M, Wild K, Lapouge K, Gese GV, Kellner N, Hurt E, Sinning I
Nat Struct Mol Biol (2023) 30 pp. 670-677 [ Pubmed: 37081320 DOI: doi:10.1038/s41594-023-00973-1 ]
- 60s ribosomal protein l33-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s26 (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l20 (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Dolichyl-diphosphooligosaccharide--protein glycotransferase (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s7 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l36 (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative 60s ribosomal protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l19 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s6 (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s16-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s4 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s acidic ribosomal protein p0 (33 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l28-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l41-a (3 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l23-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein s27-like protein (8 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l44-like protein (12 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s2-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein us14 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s27a-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 26s rrna (1 MDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s21-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l12-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l43-like protein (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s28-like protein (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s12 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s30 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s9-like protein (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l21-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El38 (9 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- El24 (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s17-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l17-like protein (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l5-like protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative heat shock protein (62 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s19-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Chaetomium thermophilum rac on 80s ribosome (Complex from Chaetomium thermophilum var. thermophilum DSM 1495)
- 40s ribosomal protein s3-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l26-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l25-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l13 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s5-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s10-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosome associated protein (51 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ul6 (21 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l27 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s15-like protein (17 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l30-like protein (11 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l3-like protein (44 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l32-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative guanine nucleotide-binding protein (35 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l18-like protein (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s23-like protein (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Putative ribosomal protein (20 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l6 (22 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s25 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l10-like protein (25 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s11-like protein (18 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l22-like protein (14 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s20-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l4-like protein (39 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l37 (10 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Magnesium ion (24 Da, Ligand)
- Nascent chain (2 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5s rrna (38 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein el39 (6 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l15 (24 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Ribosomal protein l34-like protein (13 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s0 (31 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s8 (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l29 (7 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l16-like protein (23 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l7-like protein (28 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s14-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s1 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 5.8s rrna (50 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l8 (29 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 60s ribosomal protein l2-like protein (27 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s13-like protein (16 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- Habp4_pai-rbp1 domain-containing protein (32 kDa, Protein from Thermochaetoides thermophila DSM 1495)
- 18s rrna (578 kDa, RNA from Thermochaetoides thermophila DSM 1495)
- 40s ribosomal protein s24 (15 kDa, Protein from Thermochaetoides thermophila DSM 1495)
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the hybrid inhibitor GNE-1305
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8f0p
Q-score: 0.776
Kschonsak M, Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J, Ciferri C, Tellis JC
eLife (2023) 12 [ Pubmed: 36975198 DOI: doi:10.7554/eLife.84151 ]
- Sodium channel protein pafpc1,sodium channel protein type 9 subunit alpha chimera (184 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- N-[6-(cyclopentylmethoxy)-1,3-benzothiazol-2-yl]-4-{[(1s,2s)-2-(dimethylamino)cyclohexyl]amino}-2-fluorobenzene-1-sulfonamide (546 Da, Ligand)
- Vsd4-nav1.7-navpas channel chimera bound to the hybrid inhibitor gne-1305 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Structure of VSD4-NaV1.7-NaVPas channel chimera bound to the acylsulfonamide inhibitor GDC-0310
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8f0q
Q-score: 0.739
Kschonsak M, Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J, Ciferri C, Tellis JC
eLife (2023) 12 [ Pubmed: 36975198 DOI: doi:10.7554/eLife.84151 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- Structure of vsd4-nav1.7-navpas channel chimera bound to the acylsulfonamide inhibitor gdc-0310 (Complex from Homo sapiens)
- Sodium channel protein pafpc1,sodium channel protein type 9 subunit alpha chimera (184 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (744 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
- 5-cyclopropyl-4-({1-[(1s)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl}methoxy)-2-fluoro-n-(methanesulfonyl)benzamide (543 Da, Ligand)
Structure of dodecameric KaiC-RS-S413E/S414E solved by cryo-EM
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8fwi
Q-score: 0.564
Pitsawong W, Padua RAP, Grant T, Hoemberger M, Otten R, Bradshaw N, Grigorieff N, Kern D
Nature (2023) 616 pp. 183-189 [ DOI: doi:10.1038/s41586-023-05836-9 Pubmed: 36949197 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Circadian clock protein kaic (62 kDa, Protein from Cereibacter sphaeroides)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dodecamer of kaic-rs-s413e/s414e (751 kDa, Complex from Cereibacter sphaeroides)
- Water (18 Da, Ligand)
Structure of dodecameric KaiC-RS-S413E/S414E complexed with KaiB-RS solved by cryo-EM
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8fwj
Q-score: 0.474
Pitsawong W, Padua RAP, Grant T, Hoemberger M, Otten R, Bradshaw N, Grigorieff N, Kern D
Nature (2023) 616 pp. 183-189 [ DOI: doi:10.1038/s41586-023-05836-9 Pubmed: 36949197 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dodecamer of kaic-rs-s413e/s414e bound with kaic-rs (875 kDa, Complex from Cereibacter sphaeroides)
- Circadian clock protein kaib (10 kDa, Protein from Cereibacter sphaeroides)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Circadian clock protein kaic (62 kDa, Protein from Cereibacter sphaeroides)
- Water (18 Da, Ligand)
Cryo-EM Structure of Bl_Man38A at 2.7 A
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7ufr
Q-score: 0.602
Santos CR, Cordeiro RL, Domingues MN, Borges AC, de Farias MA, Van Heel M, Murakami MT, Portugal RV
Nat Chem Biol (2022) [ ]
- Tetramer of bl_man38a (471 kDa, Complex from Bifidobacterium longum)
- Zinc ion (65 Da, Ligand)
- Alpha-mannosidase (117 kDa, Protein from Bifidobacterium longum)
Cryo-EM Structure of Bl_Man38B at 3.4 A
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ufs
Q-score: 0.486
Santos CR, Cordeiro RL, Domingues MN, Borges AC, de Farias MA, Van Heel M, Murakami MT, Portugal RV
Nat Chem Biol (2022) [ ]
- Alpha-mannosidase (118 kDa, Protein from Bifidobacterium longum)
- Zinc ion (65 Da, Ligand)
- Tetramer of bl_man38b (475 kDa, Complex from Bifidobacterium longum)