Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with primidone
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 9b28
Q-score: 0.438
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ Pubmed: 39809942 DOI: doi:10.1038/s41594-024-01463-8 ]
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Primidone (218 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with cholesteryl hemisuccinate
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 9b29
Q-score: 0.394
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ Pubmed: 39809942 DOI: doi:10.1038/s41594-024-01463-8 ]
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
Resolution: 3.82 Å
EM Method: Single-particle
Fitted PDBs: 9b2a
Q-score: 0.34
Yin Y, Park CG, Feng S, Guan Z, Lee HJ, Zhang F, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Struct Mol Biol (2025) [ Pubmed: 39809942 DOI: doi:10.1038/s41594-024-01463-8 ]
- Transient receptor potential cation channel subfamily m member 3 (Complex from Mus musculus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Pregnenolone sulfate (396 Da, Ligand)
- (2s)-2-(3,4-dihydroquinolin-1(2h)-yl)-n-(5-methyl-1,2-oxazol-3-yl)-2-phenylacetamide (347 Da, Ligand)
- Transient receptor potential cation channel, subfamily m, member 3 (198 kDa, Protein from Mus musculus)
Cryo-EM structure of human ABC transporter (hABCC1) bound to cGAMP
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8vux
Q-score: 0.372
Shinde O, Boyer JA, Cambier S, VanPortfliet JJ, Sui X, Yadav GP, Viverette EG, Borgnia MJ, West AP, Zhang Q, Stetson DB, Li P
Immunity (2025) 58 pp. 59-73.e5 [ Pubmed: 39765229 DOI: doi:10.1016/j.immuni.2024.12.002 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Homodimer of habcc1 bound to cgamp (199 kDa, Complex from Homo sapiens)
- Cgamp (674 Da, Ligand)
- Multidrug resistance-associated protein 1 (171 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8viw
Q-score: 0.511
Stancanelli E, Krahn JA, Viverette E, Dutcher R, Pagadala V, Borgnia MJ, Liu J, Pedersen LC
ACS Catal (2024) 14 pp. 6577-6588 [ DOI: doi:10.1021/acscatal.4c00677 ]
- Uridine-5'-diphosphate (404 Da, Ligand)
- Heparosan synthase b (64 kDa, Protein from Pasteurella multocida)
- Water (18 Da, Ligand)
- Pmhs2 with 7-mer polysaccharide (Cellular component from Pasteurella multocida)
- Manganese (ii) ion (54 Da, Ligand)
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Ribavirin
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8tz1
Q-score: 0.596
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) 20 pp. 1144-1153 [ DOI: doi:10.1038/s41589-024-01559-8 Pubmed: 38418906 ]
- 1-(beta-d-ribofuranosyl)-1h-1,2,4-triazole-3-carboxamide (244 Da, Ligand)
- Water (18 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in MSP2N2 nanodiscs, apo state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8tz2
Q-score: 0.555
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) 20 pp. 1144-1153 [ DOI: doi:10.1038/s41589-024-01559-8 Pubmed: 38418906 ]
- Water (18 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Sodium ion (22 Da, Ligand)
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 8tz3
Q-score: 0.649
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) 20 pp. 1144-1153 [ DOI: doi:10.1038/s41589-024-01559-8 Pubmed: 38418906 ]
- Water (18 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Sodium ion (22 Da, Ligand)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8tz4
Q-score: 0.503
Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with N-hydroxycytidine
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 8tz5
Q-score: 0.559
Wright NJ, Zhang F, Suo Y, Kong L, Yin Y, Fedor JG, Sharma K, Borgnia MJ, Im W, Lee SY
Nat Chem Biol (2024) 20 pp. 1144-1153 [ DOI: doi:10.1038/s41589-024-01559-8 Pubmed: 38418906 ]
- N-hydroxycytidine (259 Da, Ligand)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Bcnt3 trimer (232 kDa, Complex from Bos taurus)
- Sodium/nucleoside cotransporter (79 kDa, Protein from Bos taurus)
- Sodium ion (22 Da, Ligand)