Cryo-EM structure of the Nipah virus polymerase (L) bound to the tetrameric phosphoprotein (P)
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 9fux
Q-score: 0.57
Balikci E, Gunl F, Carrique L, Keown JR, Fodor E, Grimes JM
EMBO J (2025) 44 pp. 563-586 [ Pubmed: 39739115 DOI: doi:10.1038/s44318-024-00321-z ]
- Rna-directed rna polymerase l (257 kDa, Protein from Henipavirus nipahense)
- Nipah virus polymerase (l) bound to the tetrameric phosphoprotein (p) (570 kDa, Complex from Henipavirus nipahense)
- Phosphoprotein (78 kDa, Protein from Henipavirus nipahense)
- Zinc ion (65 Da, Ligand)
Human mitochondrial RNase Z with tRNA-His-CCA
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 9ey2
Q-score: 0.652
EMBO J (2024) 43 pp. 6573-6590 [ Pubmed: 39516281 DOI: doi:10.1038/s44318-024-00297-w ]
- Mt-trna-his-cca (22 kDa, RNA from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trna methyltransferase 10 homolog c (42 kDa, Protein from Homo sapiens)
- Mt-trna-his (Complex from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Zinc phosphodiesterase elac protein 2 (89 kDa, Protein from Homo sapiens)
- Rnasez with mt-trna-his (250 kDa, Complex)
- Rnasez (Complex from Homo sapiens)
Human mitochondrial RNase Z with tRNA-His-CCA, SDR5C1/TRMT10C focus
Resolution: 1.9 Å
EM Method: Single-particle
Fitted PDBs: 9gch
Q-score: 0.737
EMBO J (2024) 43 pp. 6573-6590 [ Pubmed: 39516281 DOI: doi:10.1038/s44318-024-00297-w ]
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Mt-trna-his-cca (22 kDa, RNA from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trna methyltransferase 10 homolog c (42 kDa, Protein from Homo sapiens)
- Mt-trna-his (Complex from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Rnasez with mt-trna-his (250 kDa, Complex)
- Rnasez (Complex from Homo sapiens)
Human mitochondrial RNase Z with tRNA-His
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 9ey0
Q-score: 0.546
EMBO J (2024) 43 pp. 6573-6590 [ Pubmed: 39516281 DOI: doi:10.1038/s44318-024-00297-w ]
- Mt-trna-his (22 kDa, RNA from Homo sapiens)
- S-adenosylmethionine (398 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trna methyltransferase 10 homolog c (42 kDa, Protein from Homo sapiens)
- Mt-trna-his (Complex from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Zinc phosphodiesterase elac protein 2 (89 kDa, Protein from Homo sapiens)
- Rnasez with mt-trna-his (250 kDa, Complex)
- Rnasez (Complex from Homo sapiens)
Human mitochondrial RNase Z with tRNA-His precursor
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9ey1
Q-score: 0.523
EMBO J (2024) 43 pp. 6573-6590 [ Pubmed: 39516281 DOI: doi:10.1038/s44318-024-00297-w ]
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Trna methyltransferase 10 homolog c (42 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Trna-his-trna-ser (40 kDa, RNA from Homo sapiens)
- Mt-trna-his (Complex from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Rnasez with mt-trna-his (250 kDa, Complex)
- Rnasez (Complex from Homo sapiens)
- Zinc phosphodiesterase elac protein 2 (89 kDa, Protein from Homo sapiens)
Tetrameric 5-HT3A receptor in Salipro (apo, asymmetric)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8c1w
Q-score: 0.366
Introini B, Cui W, Chu X, Zhang Y, Alves AC, Eckhardt-Strelau L, Golusik S, Tol M, Vogel H, Yuan S, Kudryashev M
EMBO J (2024) 43 pp. 4451-4471 [ DOI: doi:10.1038/s44318-024-00191-5 Pubmed: 39232129 ]
- Tetrameric 5-ht3ar receptor in salipro (apo, asymmetric) (220 kDa, Complex from Mus musculus)
- 5-hydroxytryptamine receptor 3a (60 kDa, Protein from Mus musculus)
Tetrameric 5-HT3aR in Salipro (apo state, symmetric)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8c1z
Q-score: 0.399
Introini B, Cui W, Chu X, Zhang Y, Alves AC, Eckhardt-Strelau L, Golusik S, Tol M, Vogel H, Yuan S, Kudryashev M
EMBO J (2024) 43 pp. 4451-4471 [ DOI: doi:10.1038/s44318-024-00191-5 Pubmed: 39232129 ]
- 5-hydroxytryptamine receptor 3a (60 kDa, Protein from Mus musculus)
- Tetrameric 5-ht3a receptor in salipro (apo, symmetric) (220 kDa, Complex from Mus musculus)
Tetrameric 5-HT3aR in Salipro (holo state, symmetric)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8c20
Q-score: 0.376
Introini B, Cui W, Chu X, Zhang Y, Alves AC, Eckhardt-Strelau L, Golusik S, Tol M, Vogel H, Yuan S, Kudryashev M
EMBO J (2024) 43 pp. 4451-4471 [ DOI: doi:10.1038/s44318-024-00191-5 Pubmed: 39232129 ]
- Tetrameric 5-ht3a receptor in salipro (holo, symmetric) (220 kDa, Complex from Mus musculus)
- Serotonin (176 Da, Ligand)
- 5-hydroxytryptamine receptor 3a (60 kDa, Protein from Mus musculus)
Tetrameric 5-HT3A receptor in Salipro (holo, asymmetric)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8c21
Q-score: 0.406
Introini B, Cui W, Chu X, Zhang Y, Alves AC, Eckhardt-Strelau L, Golusik S, Tol M, Vogel H, Yuan S, Kudryashev M
EMBO J (2024) 43 pp. 4451-4471 [ DOI: doi:10.1038/s44318-024-00191-5 Pubmed: 39232129 ]
- Tetrameric 5-ht3ar receptor in salipro (holo, asymmetric) (220 kDa, Complex from Mus musculus)
- 5-hydroxytryptamine receptor 3a (60 kDa, Protein from Mus musculus)
- Serotonin (176 Da, Ligand)
Resolution: 2.46 Å
EM Method: Single-particle
Fitted PDBs: 8rt4
Q-score: 0.543
EMBO J (2024) 43 pp. 3287-3306 [ Pubmed: 38886579 DOI: doi:10.1038/s44318-024-00135-z ]
- The outer membrane core complex from the fully-assembled r388 type iv secretion system (Complex from Escherichia coli)
- Trwh protein (5 kDa, Protein from Escherichia coli)
- Trwe protein (42 kDa, Protein from Escherichia coli)
- Trwf protein (29 kDa, Protein from Escherichia coli)