Cryo-EM reconstruction of PI3KC3-C1 in complex with Human RAB1A(Q70L)
Cook ASI, Chen M, Ngyuen TN, Claveras-Cabezudo A, Khuu G, Rao S, Garcia SN, Yang M, Iavarone AT, Ren X, Lazarou M, Hummer G, Hurley JH
To Be Published
- Beclin-1 (51 kDa, Protein from Homo sapiens)
- Ras-related protein rab-1a (25 kDa, Protein from Homo sapiens)
- Myristic acid (228 Da, Ligand)
- Phosphatidylinositol-3 kinase class iii complex i bound to rab1a (384 kDa, Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase catalytic subunit type 3 (101 kDa, Protein from Homo sapiens)
- Beclin 1-associated autophagy-related key regulator (55 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphoinositide 3-kinase regulatory subunit 4 (158 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Water (18 Da, Ligand)
Cook ASI, Chen M, Ngyuen TN, Claveras-Cabezudo A, Khuu G, Rao S, Garcia SN, Yang M, Iavarone AT, Ren X, Lazarou M, Hummer G, Hurley JH
To Be Published
- Beclin-1 (51 kDa, Protein from Homo sapiens)
- Ras-related protein rab-1a (25 kDa, Protein from Homo sapiens)
- Myristic acid (228 Da, Ligand)
- Phosphatidylinositol-3 kinase class iii complex i bound to rab1a (384 kDa, Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase catalytic subunit type 3 (101 kDa, Protein from Homo sapiens)
- Beclin 1-associated autophagy-related key regulator (55 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphoinositide 3-kinase regulatory subunit 4 (158 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
PI3KC3-C1 in complex with RAB1A. VPS34 kinase domain active conformation
Cook ASI, Chen M, Ngyuen TN, Claveras-Cabezudo A, Khuu G, Rao S, Garcia SN, Yang M, Iavarone AT, Ren X, Lazarou M, Hummer G, Hurley JH
To Be Published
- Beclin-1 (51 kDa, Protein from Homo sapiens)
- Ras-related protein rab-1a (25 kDa, Protein from Homo sapiens)
- Phosphatidylinositol-3 kinase class iii complex i bound to rab1a (384 kDa, Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase catalytic subunit type 3 (101 kDa, Protein from Homo sapiens)
- Beclin 1-associated autophagy-related key regulator (55 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Phosphoinositide 3-kinase regulatory subunit 4 (158 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
Cryo-EM structure of native SWR1 bound to DNA (composite structure)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9b1d
Q-score: 0.435
Louder RK, Park G, Ye Z, Cha JS, Gardner AM, Lei Q, Ranjan A, Hollmuller E, Stengel F, Pugh BF, Wu C
Cell (2024) 187 pp. 6849-6864.e18 [ DOI: doi:10.1016/j.cell.2024.09.007 Pubmed: 39357520 ]
- Dna (147-mer) (45 kDa, DNA from synthetic construct)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Native swr1 complex (Complex from Saccharomyces cerevisiae)
- Actin-like protein arp6 (50 kDa, Protein from Saccharomyces cerevisiae W303)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Helicase swr1 (178 kDa, Protein from Saccharomyces cerevisiae W303)
- Native swr1 bound to dna. (1 MDa, Complex from Saccharomyces cerevisiae)
- Ruvb-like protein 2 (51 kDa, Protein from Saccharomyces cerevisiae W303)
- Dna (147-mer) (45 kDa, DNA from synthetic construct)
- Vacuolar protein sorting-associated protein 71 (32 kDa, Protein from Saccharomyces cerevisiae W303)
- Vacuolar protein sorting-associated protein 72 (90 kDa, Protein from Saccharomyces cerevisiae W303)
- Ruvb-like protein 1 (91 kDa, Protein from Saccharomyces cerevisiae W303)
Glutamine synthetase from Pseudomonas aeruginosa, filament double-unit in compressed conformation
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8fbp
Q-score: 0.082
Structure of the Ancestral Scaffold Antigen-5 of Coronavirus Spike protein
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8aja
Q-score: 0.604
Hueting D, Schriever K, Sun R, Vlachiotis S, Zuo F, Du L, Persson H, Hofstrom C, Ohlin M, Wallden K, Buggert M, Hammarstrom L, Marcotte H, Pan-Hammarstrom Q, Andrell J, Syren PO
Nat Commun (2023) 14 pp. 6527-6527 [ Pubmed: 37845250 DOI: doi:10.1038/s41467-023-42200-x ]
Structure of the Ancestral Scaffold Antigen-6 of Coronavirus Spike protein
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8ajl
Q-score: 0.555
Hueting D, Schriever K, Sun R, Vlachiotis S, Zuo F, Du L, Persson H, Hofstrom C, Ohlin M, Wallden K, Buggert M, Hammarstrom L, Marcotte H, Pan-Hammarstrom Q, Andrell J, Syren PO
Nat Commun (2023) 14 pp. 6527-6527 [ Pubmed: 37845250 DOI: doi:10.1038/s41467-023-42200-x ]
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8dpz
Q-score: 0.518
Stalls V, Acharya P, May AJ, Malewana D
To Be Published
- Ab026500 fab bound to sars-cov-2 hexapro spike s1 local refinement (557 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Dh1338 fab light chain (11 kDa, Protein from Macaca mulatta)
- Dh1338 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Spike protein s1 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Stalls V, Acharya P, Malewana D
To Be Published
- Dh1338 fab heavy chain (Macromolecule from Macaca mulatta)
- Spike glycoprotein hexapro (Macromolecule from Severe acute respiratory syndrome coronavirus 2)
- Ab026500 fab bound to sars-cov-2 hexapro spike trimer (556 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Dh1338 fab light chain (Macromolecule from Macaca mulatta)