Cryo-EM reconstruction of PI3KC3-C1 in complex with Human RAB1A(Q70L)
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 9mhf
Q-score: 0.588
Cook ASI, Chen M, Ngyuen TN, Claveras-Cabezudo A, Khuu G, Rao S, Garcia SN, Yang M, Iavarone AT, Ren X, Lazarou M, Hummer G, Hurley JH
To Be Published
- Beclin-1 (51 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Beclin 1-associated autophagy-related key regulator (55 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 3-kinase catalytic subunit type 3 (101 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ras-related protein rab-1a (25 kDa, Protein from Homo sapiens)
- Phosphoinositide 3-kinase regulatory subunit 4 (158 kDa, Protein from Homo sapiens)
- Phosphatidylinositol-3 kinase class iii complex i bound to rab1a (384 kDa, Complex from Homo sapiens)
- Myristic acid (228 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9mhg
Q-score: 0.43
Cook ASI, Chen M, Ngyuen TN, Claveras-Cabezudo A, Khuu G, Rao S, Garcia SN, Yang M, Iavarone AT, Ren X, Lazarou M, Hummer G, Hurley JH
To Be Published
- Beclin-1 (51 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Beclin 1-associated autophagy-related key regulator (55 kDa, Protein from Homo sapiens)
- Phosphatidylinositol-3 kinase class iii complex i bound to rab1a (384 kDa, Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase catalytic subunit type 3 (101 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ras-related protein rab-1a (25 kDa, Protein from Homo sapiens)
- Phosphoinositide 3-kinase regulatory subunit 4 (158 kDa, Protein from Homo sapiens)
- Myristic acid (228 Da, Ligand)
PI3KC3-C1 in complex with RAB1A. VPS34 kinase domain active conformation
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 9mhh
Q-score: 0.373
Cook ASI, Chen M, Ngyuen TN, Claveras-Cabezudo A, Khuu G, Rao S, Garcia SN, Yang M, Iavarone AT, Ren X, Lazarou M, Hummer G, Hurley JH
To Be Published
- Beclin-1 (51 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Beclin 1-associated autophagy-related key regulator (55 kDa, Protein from Homo sapiens)
- Phosphatidylinositol-3 kinase class iii complex i bound to rab1a (384 kDa, Complex from Homo sapiens)
- Phosphatidylinositol 3-kinase catalytic subunit type 3 (101 kDa, Protein from Homo sapiens)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Ras-related protein rab-1a (25 kDa, Protein from Homo sapiens)
- Phosphoinositide 3-kinase regulatory subunit 4 (158 kDa, Protein from Homo sapiens)
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 7ub0
Q-score: 0.518
Stalls V, Lindenberger J, Gobeil SM, Henderson R, Parks R, Barr M, Deyton M, Martin M, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Kraft B, Lu X, Edwards RJ, Eaton A, Montefiori DC, Williams WB, Saunders KO, Wiehe K, Haynes BF, Acharya P
Cell Rep (2022) 39 pp. 111009-111009 [ Pubmed: 35732171 DOI: doi:10.1016/j.celrep.2022.111009 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s-gsas-omicron-ba.2 spike ectodomain (427 kDa, Complex from Homo sapiens)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7ub5
Q-score: 0.504
Stalls V, Lindenberger J, Gobeil SM, Henderson R, Parks R, Barr M, Deyton M, Martin M, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Kraft B, Lu X, Edwards RJ, Eaton A, Montefiori DC, Williams WB, Saunders KO, Wiehe K, Haynes BF, Acharya P
Cell Rep (2022) 39 pp. 111009-111009 [ Pubmed: 35732171 DOI: doi:10.1016/j.celrep.2022.111009 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s-gsas-omicron-ba.2 spike ectodomain (427 kDa, Complex from Homo sapiens)
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 7ub6
Q-score: 0.483
Stalls V, Lindenberger J, Gobeil SM, Henderson R, Parks R, Barr M, Deyton M, Martin M, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Kraft B, Lu X, Edwards RJ, Eaton A, Montefiori DC, Williams WB, Saunders KO, Wiehe K, Haynes BF, Acharya P
Cell Rep (2022) 39 pp. 111009-111009 [ Pubmed: 35732171 DOI: doi:10.1016/j.celrep.2022.111009 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s-gsas-omicron-ba.2 spike ectodomain (427 kDa, Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7tl1
Q-score: 0.441
Gobeil SM, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Eaton A, Montefiori DC, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P
Mol Cell (2022) 82 pp. 2050-2068.e6 [ DOI: doi:10.1016/j.molcel.2022.03.028 Pubmed: 35447081 ]
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7tei
Q-score: 0.464
Gobeil SM, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Eaton A, Montefiori DC, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P
Mol Cell (2022) 82 pp. 2050-2068.e6 [ DOI: doi:10.1016/j.molcel.2022.03.028 Pubmed: 35447081 ]
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 7tf8
Q-score: 0.468
Gobeil SM, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Eaton A, Montefiori DC, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P
Mol Cell (2022) 82 pp. 2050-2068.e6 [ DOI: doi:10.1016/j.molcel.2022.03.028 Pubmed: 35447081 ]