Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ys6
Q-score: 0.429
He L, Zhao QY, Qi J, Wang Y, Han W, Chen Z, Cong Y, Wang S
PNAS (2023) 120 pp. e2209917120-e2209917120 [ DOI: doi:10.1073/pnas.2209917120 Pubmed: 36989299 ]
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Serotonin 6 (5-ht6) receptor-dngs-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Serotonin (176 Da, Ligand)
- 5-hydroxytryptamine receptor 6 (33 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 7vie
Q-score: 0.537
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ Pubmed: 35412894 DOI: doi:10.1073/pnas.2117716119 ]
- S1pr1/gi (Complex from Mus musculus)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Scfv16 (Complex)
- S1pr1/gi complex with s1p (Complex from Homo sapiens)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7vif
Q-score: 0.553
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ Pubmed: 35412894 DOI: doi:10.1073/pnas.2117716119 ]
- S1pr1/gi (Complex from Mus musculus)
- Scfv16 (26 kDa, Protein from Mus musculus)
- (2~{s})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol (387 Da, Ligand)
- S1pr1/gi complex with fty720p (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (Complex)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7vig
Q-score: 0.563
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ Pubmed: 35412894 DOI: doi:10.1073/pnas.2117716119 ]
- S1pr1/gi (Complex from Mus musculus)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid (409 Da, Ligand)
- S1pr1/gi complex with cbp-307 (Complex from Homo sapiens)
- Scfv16 (Complex)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7vih
Q-score: 0.521
Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R
PNAS (2022) 119 pp. e2117716119-e2117716119 [ Pubmed: 35412894 DOI: doi:10.1073/pnas.2117716119 ]
- S1pr1/gi (Complex from Mus musculus)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid (409 Da, Ligand)
- S1pr1/gi complex with cbp-307 (Complex from Homo sapiens)
- Scfv16 (Complex)
- Sphingosine 1-phosphate receptor 1 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)