mycobacterial efflux pump, apo state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1m
Q-score: 0.574
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- (1s)-2-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (746 Da, Ligand)
- Multidrug efflux system atp-binding protein rv1218c (31 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, substrate-bound state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1n
Q-score: 0.541
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Rifampicin (822 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, AMPPNP bound state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1o
Q-score: 0.597
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Structure of HCoV-HKU1A spike in the functionally anchored-3up conformation with 3TMPRSS2
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8y7x
Q-score: 0.331
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (141 kDa, Protein from Human coronavirus HKU1 (isolate N1))
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
Local structure of HCoV-HKU1A spike in complex with TMPRSS2 and glycan
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8y7y
Q-score: 0.577
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Methyl 9-o-acetyl-5-acetamido-3,5-dideoxy-d-glycero-alpha-d-galacto-non-2-ulopyranosidonic acid (365 Da, Ligand)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Human coronavirus HKU1 (isolate N1))
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of HCoV-HKU1C spike in the functionally anchored-1up conformation with 1TMPRSS2
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8y87
Q-score: 0.355
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Hku1b-tmprss2 complex (Complex from Human coronavirus HKU1)
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1 (isolate N5))
Structure of HCoV-HKU1C spike in the functionally anchored-2up conformation with 2TMPRSS2
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 8y88
Q-score: 0.37
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Hku1a-tmprss2 complex (Complex from Human coronavirus HKU1)
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 2TMPRSS2
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8y89
Q-score: 0.296
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1)
- Hku1c-tmprss2 complex (Complex from Human coronavirus HKU1)
Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 3TMPRSS2
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8y8a
Q-score: 0.308
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1 (isolate N5))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hku1b-tmprss2 complex (Complex from Human coronavirus HKU1)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
Local structure of HCoV-HKU1C spike in complex with TMPRSS2 and glycan
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8y8b
Q-score: 0.597
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H
Cell (2024) 187 pp. 4261- [ DOI: doi:10.1016/j.cell.2024.06.016 Pubmed: 38964329 ]
- Spike glycoprotein (140 kDa, Protein from Human coronavirus HKU1 (isolate N5))
- Methyl 9-o-acetyl-5-acetamido-3,5-dideoxy-d-glycero-alpha-d-galacto-non-2-ulopyranosidonic acid (365 Da, Ligand)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
- Hku1c-tmprss2 complex (Complex from Human coronavirus HKU1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)