Cryo-EM structure of human apo GPR156
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8yjp
Q-score: 0.396
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ Pubmed: 39638804 DOI: doi:10.1038/s41467-024-54681-5 ]
- Probable g-protein coupled receptor 156 (38 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Gpr156 (Cellular component from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human GPR156-Gi3 complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8yk0
Q-score: 0.501
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ Pubmed: 39638804 DOI: doi:10.1038/s41467-024-54681-5 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Bos taurus)
- Probable g-protein coupled receptor 156 (32 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Gpr156-gi3 complex (Cellular component from Homo sapiens)
- Probable g-protein coupled receptor 156 (35 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8yw3
Q-score: 0.514
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucagon-like peptide-1 receptor in complex with retatrutide and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Cryo-EM structure of the inward-facing FLVCR1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8qcs
Q-score: 0.554
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Flvcr1 monomer (60 kDa, Complex from Homo sapiens)
- Heme transporter flvcr1 (60 kDa, Protein from Homo sapiens)
Cryo-EM structure of the inward-facing choline-bound FLVCR1
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8qct
Q-score: 0.631
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Choline-bound flvcr1 monomer (60 kDa, Complex from Homo sapiens)
- Heme transporter flvcr1 (60 kDa, Protein from Homo sapiens)
- Choline ion (104 Da, Ligand)
Cryo-EM structure of the inward-facing FLVCR2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8qcx
Q-score: 0.527
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Heme transporter flvcr2 (58 kDa, Protein from Homo sapiens)
- Flvcr2 monomer (58 kDa, Complex from Homo sapiens)
Cryo-EM structure of the outward-facing FLVCR2
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8qcy
Q-score: 0.541
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Heme transporter flvcr2 (58 kDa, Protein from Homo sapiens)
- Flvcr2 monomer (58 kDa, Complex from Homo sapiens)
Cryo-EM structure of the inward-facing choline-bound FLVCR2
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8qd0
Q-score: 0.517
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Heme transporter flvcr2 (58 kDa, Protein from Homo sapiens)
- Flvcr2 monomer (58 kDa, Complex from Homo sapiens)
- Choline ion (104 Da, Ligand)
Cryo-EM structure of the inward-facing ethanolamine-bound FLVCR1
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8r8t
Q-score: 0.581
Ri K, Weng TH, Claveras Cabezudo A, Josting W, Zhang Y, Bazzone A, Leong NCP, Welsch S, Doty RT, Gursu G, Lim TJY, Schmidt SL, Abkowitz JL, Hummer G, Wu D, Nguyen LN, Safarian S
Nature (2024) 630 pp. 501-508 [ DOI: doi:10.1038/s41586-024-07444-7 Pubmed: 38778100 ]
- Ethanolamine-bound flvcr1 monomer (60 kDa, Complex from Homo sapiens)
- Heme transporter flvcr1 (60 kDa, Protein from Homo sapiens)
- Ethanolamine (61 Da, Ligand)
Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xzg
Q-score: 0.495
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the [pyr1]-apelin-13-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)