Cryo-EM structure of the beta-1,3-glucan synthase FKS1-Rho1 complex
Cryo-EM structure of human gamma-secretase in complex with RO4929097
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with ro4929097 (Complex from Homo sapiens)
- 2,2-dimethyl-n-[(7s)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-n'-(2,2,3,3,3-pentafluoropropyl)propanediamide (469 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with Crenigacestat
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- 4,4,4-tris(fluoranyl)-n-[(2s)-1-[[(7s)-5-(2-hydroxyethyl)-6-oxidanylidene-7h-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxidanylidene-propan-2-yl]butanamide (464 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with crenigacestat (Complex from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with BMS906024
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- Cryo-em structure of human gamma-secretase in complex with bms906024 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Osugacestat (556 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Nirogacestat (489 Da, Ligand)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with nirogacestat (Complex from Homo sapiens)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with MK-0752
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Mk-0752 (442 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with mk-0752 (Complex from Homo sapiens)
- Nicastrin (77 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8wgr
Q-score: 0.576
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ Pubmed: 39048818 DOI: doi:10.1038/s41586-024-07719-z ]
- Net (110 kDa, Complex from Homo sapiens)
- 3-(10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n-methylpropan-1-amine (266 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8wgx
Q-score: 0.462
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ Pubmed: 39048818 DOI: doi:10.1038/s41586-024-07719-z ]
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Net (110 kDa, Complex from Homo sapiens)
- L-norepinephrine (169 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8z1l
Q-score: 0.451
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ Pubmed: 39048818 DOI: doi:10.1038/s41586-024-07719-z ]
- (3r)-n-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine (255 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Net (110 kDa, Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)