Structure of the human endogenous PCNA-FEN1 complex - State A
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8yjh
Q-score: 0.421
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Endogenous state a pcna-dna-fen1 complex (Complex from Homo sapiens)
- Downstream dna chain f (3 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- 5 prime dna (867 Da, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Upstream dna chain j (4 kDa, DNA from Homo sapiens)
- Parent strand chain e (7 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State B
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjl
Q-score: 0.448
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Upstream dna (5 kDa, DNA from Homo sapiens)
- Parent strand (8 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- 5 prime dna (867 Da, DNA from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Endogenous state b pcna-dna-fen1 complex (Complex from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State C
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjq
Q-score: 0.441
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Endogenous state c pcna-dna-fen1 complex (Complex from Homo sapiens)
- Upstream dna (5 kDa, DNA from Homo sapiens)
- 5 prime flap dna (1 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Parent strand (8 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State D
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjr
Q-score: 0.423
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Endogenous state d pcna-dna-fen1 complex (Complex from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Parent dna (9 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State E
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8yjs
Q-score: 0.443
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Endogenous state e pcna-dna-fen1 complex (Complex from Homo sapiens)
- Parent strand dna (8 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Upstream dna (5 kDa, DNA from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State F
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8yju
Q-score: 0.399
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Downstream dna (3 kDa, DNA from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Endogenous state f pcna-dna-fen1 complex (Complex from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1 complex - State G
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8yjv
Q-score: 0.447
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Upstream dna (6 kDa, DNA from Homo sapiens)
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Endogenous state g pcna-dna-fen1 complex (Complex from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sa)
Structure of the human endogenous PCNA-FEN1 complex - State H
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- 5 prime flap dna (867 Da, DNA from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Endogenous state h pcna-dna-fen1 complex (Complex from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Downstream dna (3 kDa, DNA from Homo sapiens)
Structure of the human endogenous PCNA-FEN1-RNase H2 complex - State D
Resolution: 5.15 Å
EM Method: Single-particle
Fitted PDBs: 8yjz
Q-score: 0.302
EMBO J (2025) 44 pp. 484-504 [ DOI: doi:10.1038/s44318-024-00296-x Pubmed: 39578540 ]
- Ribonuclease h2 subunit b (35 kDa, Protein from Homo sapiens)
- Ribonuclease h2 subunit c (17 kDa, Protein from Homo sapiens)
- Parent strand dna (9 kDa, DNA from Homo sapiens)
- Proliferating cell nuclear antigen (28 kDa, Protein from Homo sapiens)
- Downstream dna (4 kDa, DNA from Homo sapiens)
- Ribonuclease h2 subunit a (33 kDa, Protein from Homo sapiens)
- Flap endonuclease 1 (42 kDa, Protein from Homo sapiens)
- Upstream dna (6 kDa, DNA from Homo sapiens)
- Endogenous state d pcna-dna-fen1-rnase h2 complex (Complex from Homo sapiens)
The structure of EfpA_BRD-8000.3 complex
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8ynz
Q-score: 0.406
Li D, Zhang X, Yao Y, Sun X, Sun J, Ma X, Yuan K, Bai G, Pang X, Hua R, Guo T, Mi Y, Wu L, Zhang J, Wu Y, Liu Y, Wang P, Wong CCL, Chen XW, Xiao H, Gao GF, Gao F
PNAS (2024) 121 pp. e2412653121-e2412653121 [ DOI: doi:10.1073/pnas.2412653121 Pubmed: 39441632 ]
- Efpa (Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- (1s,3s)-n-[6-bromo-5-(pyrimidin-2-yl)pyridin-2-yl]-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxamide (401 Da, Ligand)
- Uncharacterized mfs-type transporter efpa (59 kDa, Protein from Mycobacterium tuberculosis H37Rv)