Ca2+ bound intermediate state of hSlo1 + beta2N-beta4 channel in detergent.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun (2025) 16 pp. 1769-1769 [ DOI: doi:10.1038/s41467-025-56844-4 Pubmed: 39971906 ]
- Calcium ion (40 Da, Ligand)
- Inactivating beta2n-beta4 subunit chimera (Complex from Homo sapiens)
- Hslo1 channel (Complex from Homo sapiens)
- Ca2+ bound bk channel complex of hslo1 + beta2n-beta4 subunit (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Large-conductance ca2+-activated k+ channel beta2 subunit,calcium-activated potassium channel subunit beta-4 (27 kDa, Protein from Homo sapiens)
- Isoform 5 of calcium-activated potassium channel subunit alpha-1 (118 kDa, Protein from Homo sapiens)
Ca2+ free hSlo1 + beta2N-beta4 channel in detergent.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun (2025) 16 pp. 1769-1769 [ DOI: doi:10.1038/s41467-025-56844-4 Pubmed: 39971906 ]
- Inactivating beta2n-beta4 subunit chimera (Complex from Homo sapiens)
- Hslo1 channel (Complex from Homo sapiens)
- Ca2+ free bk channel complex of hslo1 + beta2n-beta4 subunit (Complex from Homo sapiens)
- Large-conductance ca2+-activated k+ channel beta2 subunit,calcium-activated potassium channel subunit beta-4 (27 kDa, Protein from Homo sapiens)
- Isoform 5 of calcium-activated potassium channel subunit alpha-1 (118 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Potassium ion (39 Da, Ligand)
Ca2+ free hSlo1 + beta2N-beta4 channel in nanodisc.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun (2025) 16 pp. 1769-1769 [ DOI: doi:10.1038/s41467-025-56844-4 Pubmed: 39971906 ]
- Inactivating beta2n-beta4 subunit chimera (Complex from Homo sapiens)
- Hslo1 channel (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Ca2+ free bk channel complex of hslo1 + beta2n-beta4 subunit (Complex from Homo sapiens)
- Large-conductance ca2+-activated k+ channel beta2 subunit,calcium-activated potassium channel subunit beta-4 (27 kDa, Protein from Homo sapiens)
- Isoform 5 of calcium-activated potassium channel subunit alpha-1 (118 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Ca2+ bound open-inactivated hSlo1 + beta2N-beta4 channel in nanodisc.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun (2025) 16 pp. 1769-1769 [ DOI: doi:10.1038/s41467-025-56844-4 Pubmed: 39971906 ]
- Magnesium ion (24 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Inactivating beta2n-beta4 subunit chimera (Complex from Homo sapiens)
- Hslo1 channel (Complex from Homo sapiens)
- Ca2+ bound bk channel complex of hslo1 + beta2n-beta4 subunit (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Large-conductance ca2+-activated k+ channel beta2 subunit,calcium-activated potassium channel subunit beta-4 (27 kDa, Protein from Homo sapiens)
- Isoform 5 of calcium-activated potassium channel subunit alpha-1 (118 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Ca2+ bound intermediate state of hSlo1 + beta2N-beta4 channel in nanodisc.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun (2025) 16 pp. 1769-1769 [ DOI: doi:10.1038/s41467-025-56844-4 Pubmed: 39971906 ]
- Calcium ion (40 Da, Ligand)
- Inactivating beta2n-beta4 subunit chimera (Complex from Homo sapiens)
- Hslo1 channel (Complex from Homo sapiens)
- Ca2+ bound bk channel complex of hslo1 + beta2n-beta4 subunit (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Large-conductance ca2+-activated k+ channel beta2 subunit,calcium-activated potassium channel subunit beta-4 (27 kDa, Protein from Homo sapiens)
- Isoform 5 of calcium-activated potassium channel subunit alpha-1 (118 kDa, Protein from Homo sapiens)
Ca2+ bound open-inactivated hSlo1 + beta2N-beta4 channel in detergent.
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun (2025) 16 pp. 1769-1769 [ DOI: doi:10.1038/s41467-025-56844-4 Pubmed: 39971906 ]
- Magnesium ion (24 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Inactivating beta2n-beta4 subunit chimera (Complex from Homo sapiens)
- Hslo1 channel (Complex from Homo sapiens)
- Ca2+ bound bk channel complex of hslo1 + beta2n-beta4 subunit (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Large-conductance ca2+-activated k+ channel beta2 subunit,calcium-activated potassium channel subunit beta-4 (27 kDa, Protein from Homo sapiens)
- Isoform 5 of calcium-activated potassium channel subunit alpha-1 (118 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Ca2+ bound open-inactivated hSlo1 + beta2N-beta4 channel in detergent- Class 2
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun (2025) 16 pp. 1769-1769 [ DOI: doi:10.1038/s41467-025-56844-4 Pubmed: 39971906 ]
- Isoform 5 of calcium-activated potassium channel subunit alpha-1 (Protein from Homo sapiens)
- Inactivating beta2n-beta4 subunit chimera (Complex from Homo sapiens)
- Hslo1 channel (Complex from Homo sapiens)
- Large-conductance ca2+-activated k+ channel beta2 subunit,calcium-activated potassium channel subunit beta-4 chimera (Protein from Homo sapiens)
- Ca2+ bound bk channel complex of hslo1 + beta2n-beta4 subunit (Complex from Homo sapiens)
Ca2+ bound open-inactivated hSlo1 + beta2N-beta4 channel in detergent-Class 3
Agarwal S, Kim ED, Lee S, Simon A, Accardi A, Nimigean CM
Nat Commun (2025) 16 pp. 1769-1769 [ DOI: doi:10.1038/s41467-025-56844-4 Pubmed: 39971906 ]
- Isoform 5 of calcium-activated potassium channel subunit alpha-1 (Protein from Homo sapiens)
- Inactivating beta2n-beta4 subunit chimera (Complex from Homo sapiens)
- Hslo1 channel (Complex from Homo sapiens)
- Large-conductance ca2+-activated k+ channel beta2 subunit,calcium-activated potassium channel subunit beta-4 chimera (Protein from Homo sapiens)
- Ca2+ bound bk channel complex of hslo1 + beta2n-beta4 subunit (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8uc7
Q-score: 0.553
Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM
Nature (2024) 632 pp. 451-459 [ Pubmed: 39085604 DOI: doi:10.1038/s41586-024-07743-z ]
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (74 kDa, Protein from Homo sapiens)
- Hcn1 with propofol (Complex from Homo sapiens)
- 2,6-bis(1-methylethyl)phenol (178 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8uc8
Q-score: 0.539
Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM
Nature (2024) 632 pp. 451-459 [ Pubmed: 39085604 DOI: doi:10.1038/s41586-024-07743-z ]