CLC-ec1 E202Y at pH 4.5 100mM Cl Turn
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ga0
Q-score: 0.475
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A
Nat Struct Mol Biol (2024) 31 pp. 644-656 [ Pubmed: 38279055 DOI: doi:10.1038/s41594-023-01210-5 ]
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Swap
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8ga1
Q-score: 0.626
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A
Nat Struct Mol Biol (2024) 31 pp. 644-656 [ Pubmed: 38279055 DOI: doi:10.1038/s41594-023-01210-5 ]
- H(+)/cl(-) exchange transporter clca (49 kDa, Protein from Escherichia coli)
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
- Structure of ecclc-r230c/l249c/c85a mutant at ph 4.5 in 100mm cl (Cell from Escherichia coli)
CLC-ec1 R230C/L249C/C85A at pH 4.5 100mM Cl Turn
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8ga3
Q-score: 0.529
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A
Nat Struct Mol Biol (2024) 31 pp. 644-656 [ Pubmed: 38279055 DOI: doi:10.1038/s41594-023-01210-5 ]
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Intermediate
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8ga5
Q-score: 0.626
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A
Nat Struct Mol Biol (2024) 31 pp. 644-656 [ Pubmed: 38279055 DOI: doi:10.1038/s41594-023-01210-5 ]
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- H(+)/cl(-) exchange transporter clca (49 kDa, Protein from Escherichia coli)
- Structure of ecclc-l25c/a450c/c85a mutant at ph 4.5 in 100mm cl (Cell from Escherichia coli)
CLC-ec1 L25C/A450C/C85A at pH 4.5 100mM Cl Twist
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8gah
Q-score: 0.571
Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A
Nat Struct Mol Biol (2024) 31 pp. 644-656 [ Pubmed: 38279055 DOI: doi:10.1038/s41594-023-01210-5 ]
nhTMEM16 L302A +Ca2+ in nanodiscs
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6oy3
Q-score: 0.456
Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H
Nat Commun (2019) 10 pp. 4972-4972 [ Pubmed: 31672969 DOI: doi:10.1038/s41467-019-12865-4 ]
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 6r7x
Q-score: 0.516
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Undecyl-maltoside (496 Da, Ligand)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7y
Q-score: 0.417
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
Resolution: 5.14 Å
EM Method: Single-particle
Fitted PDBs: 6r7z
Q-score: 0.269
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
afTMEM16 reconstituted in nanodiscs in the absence of Ca2+
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 6dz7
Q-score: 0.393
Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A
eLife (2019) 8 [ Pubmed: 30648972 DOI: doi:10.7554/eLife.43229 ]