Structure of the prefusion HKU5-19s Spike trimer (conformation 1)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9ea0
Q-score: 0.702
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Water (18 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Folic acid (441 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the prefusion HKU5-19s Spike trimer (conformation 2)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9eh8
Q-score: 0.741
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Water (18 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Folic acid (441 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the HKU5 RBD bound to the P. abramus ACE2 receptor
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9d32
Q-score: 0.564
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Spike glycoprotein (29 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Angiotensin-converting enzyme (89 kDa, Protein from Pipistrellus abramus)
- Zinc ion (65 Da, Ligand)
- Hku5 rbd bound to the p. abramus ace2 receptor (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the HKU5-19s RBD bound to the Bos taurus ACE2 receptor
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9e0i
Q-score: 0.676
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Spike glycoprotein (29 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Water (18 Da, Ligand)
- Hku5-19s rbd bound to the bos taurus ace2 receptor (Complex from Homo sapiens)
- Angiotensin-converting enzyme 2 (89 kDa, Protein from Bos taurus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9asd
Q-score: 0.506
Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota Jr E, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN
Cell (2024) 187 pp. 7196- [ DOI: doi:10.1016/j.cell.2024.09.026 Pubmed: 39383863 ]
- Vir-7229 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Homo sapiens)
- Vir-7229 fab heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba 2.86 rbd - s2v29 complex (local refinement) (Complex from Sarbecovirus)
VIR-7229 Fab fragment bound the BA.2.86 spike trimer (global refinement)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9au2
Q-score: 0.499
Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota Jr E, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN
Cell (2024) 187 pp. 7196- [ DOI: doi:10.1016/j.cell.2024.09.026 Pubmed: 39383863 ]
- Vir-7229 fab light chain (23 kDa, Protein from Homo sapiens)
- Vir-7229 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ba.2.86 spike glycoprotein in complex with vir-7229 fab (Complex from Severe acute respiratory syndrome coronavirus 2)