Structure of PDE6C without inhibitory p gamma
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ Pubmed: 39739818 DOI: doi:10.1073/pnas.2419732121 ]
- Cone pde6 (218 kDa, Complex from Homo sapiens)
- Pde6c (Protein from Homo sapiens)
Structure of PDE6C in complex with inhibitory cone p gamma in the presence of cGMP
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9cxg
Q-score: 0.453
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ Pubmed: 39739818 DOI: doi:10.1073/pnas.2419732121 ]
- Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (97 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-monophosphate (363 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Pde6c cone p gamma complex (218 kDa, Complex from Homo sapiens)
- Cone p gamma (13 kDa, Protein from Homo sapiens)
Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the presence of cGMP
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9cxh
Q-score: 0.518
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ Pubmed: 39739818 DOI: doi:10.1073/pnas.2419732121 ]
- Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (97 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-monophosphate (363 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cone pde6 ion complex with rod p gamma (218 kDa, Complex from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase subunit gamma (11 kDa, Protein from Bos taurus)
Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the absence of added cGMP
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9cxi
Q-score: 0.523
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ Pubmed: 39739818 DOI: doi:10.1073/pnas.2419732121 ]
- Magnesium ion (24 Da, Ligand)
- Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (97 kDa, Protein from Homo sapiens)
- Cone pde6 (218 kDa, Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Rod pg (11 kDa, Protein from Mus musculus)
Structure of PDE6C in complex with the rod inhibitory p gamma subunit with disordered GafA region
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9cxj
Q-score: 0.445
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ Pubmed: 39739818 DOI: doi:10.1073/pnas.2419732121 ]
- Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (97 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Cone pde6c in complex with rod p gamma (218 kDa, Complex from Homo sapiens)
- Retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase subunit gamma (11 kDa, Protein from Bos taurus)
Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8eoa
Q-score: 0.343
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ DOI: doi:10.1016/j.str.2022.12.014 Pubmed: 36657440 ]
- Magnesium ion (24 Da, Ligand)
- Aryl-hydrocarbon-interacting protein-like 1 (40 kDa, Protein from Mus musculus)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Hsp90b/aipl1 complex (215 kDa, Complex from Homo sapiens)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HSP90B in the closed state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8eob
Q-score: 0.516
Srivastava D, Yadav RP, Singh S, Boyd K, Artemyev NO
Structure (2023) 31 pp. 309- [ DOI: doi:10.1016/j.str.2022.12.014 Pubmed: 36657440 ]
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Heat shock protein hsp 90-beta (87 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Hsp90b dimer in the closed amppnp bound state (174 kDa, Complex from Homo sapiens)