Structure of Bispecific CAP256V2LS-J3 Fab in complex with BG505 DS-SOSIP.664
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8fis
Q-score: 0.453
Zhang B, Gorman J, Kwon YD, Pegu A, Chao CW, Liu T, Asokan M, Bender MF, Bylund T, Damron L, Gollapudi D, Lei P, Li Y, Liu C, Louder MK, McKee K, Olia AS, Rawi R, Schon A, Wang S, Yang ES, Yang Y, Carlton K, Doria-Rose NA, Shapiro L, Seaman MS, Mascola JR, Kwong PD
MABs (2023) 15 pp. 2165390-2165390 [ Pubmed: 36729903 DOI: doi:10.1080/19420862.2023.2165390 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cap256v2ls-j3-3 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- J3-vrc26.25 light (37 kDa, Protein from Lama glama)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vrc26.25 heavy (26 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of VRC01.23 in complex with HIV-1 Env BG505 DS.SOSIP
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 6vi0
Q-score: 0.502
Kwon YD, Asokan M, Gorman J, Zhang B, Liu Q, Louder MK, Lin BC, McKee K, Pegu A, Verardi R, Yang ES, Program VP, Carlton K, Doria-Rose NA, Lusso P, Mascola JR, Kwong PD
MABs () 13 pp. 1946918-1946918 [ Pubmed: 34328065 DOI: doi:10.1080/19420862.2021.1946918 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vrc01.23 light chain (22 kDa, Protein from Homo sapiens)
- Bg505 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Vrc01.23 heavy chain (25 kDa, Protein from Homo sapiens)
- Hiv-1 env bg505 ds-sosip and antibodies vrc01.23 (Complex)
- Bg505 ds.sosip with antibody vrc01.23 fab (Complex from Human immunodeficiency virus 1)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6cde
Q-score: 0.443
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- Pgt122 light chain (22 kDa, Protein from Homo sapiens)
- Glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Vfp20.01 (Complex from Homo sapiens)
- Glycoprotein (Complex from Human immunodeficiency virus 1)
- Vfp20.01 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein 41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Vrc03 light chain (23 kDa, Protein from Homo sapiens)
- Pgt122 (Complex from Homo sapiens)
- Vrc03 (Complex from Homo sapiens)
- Vfp20.01-bg505 ds-sosip-vrc03-pgt122 (Complex)
- Pgt122 heavy chain (24 kDa, Protein from Homo sapiens)
- Vfp20.01 heavy chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6cdi
Q-score: 0.432
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Glycoprotein (Complex from Human immunodeficiency virus 1)
- Vfp16.02 heavy chain (22 kDa, Protein from Homo sapiens)
- Vfp16.02 (Complex from Homo sapiens)
- Vfp16.02 light chain (23 kDa, Protein from Homo sapiens)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Pgt122 (Complex from Homo sapiens)
- Vrc03 light chain (11 kDa, Protein from Homo sapiens)
- Vrc03 (Complex from Homo sapiens)
- Glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vfp20.01-bg505 ds-sosip-vrc03-pgt122 (Complex)
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Bg505 ds-sosip (Protein from Human immunodeficiency virus 1)
- Hiv-1 env trimer in complex with antibody (Complex from Human immunodeficiency virus 1)
- Vfp1.01 light chain (Protein from Homo sapiens)
- Vfp1.01 heavy chain (Protein from Homo sapiens)
- Hiv-1 env trimer (Complex from Human immunodeficiency virus 1)
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]