Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C118 (State 1)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7rkv
Q-score: 0.3
Jette CA, Cohen AA, Gnanapragasam PNP, Muecksch F, Lee YE, Huey-Tubman KE, Schmidt F, Hatziioannou T, Bieniasz PD, Nussenzweig MC, West Jr AP, Keeffe JR, Bjorkman PJ, Barnes CO
Cell Rep (2021) 36 pp. 109760-109760 [ Pubmed: 34534459 DOI: doi:10.1016/j.celrep.2021.109760 ]
- C118 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Ternary complex of c118 fabs bound to the stabilized sars-cov-2 spike glycoprotein (720 kDa, Complex from Homo sapiens)
- C118 fab light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the SARS-CoV-2 S 6P trimer in complex with neutralizing antibody C118 (State 2)
Jette CA, Cohen AA, Gnanapragasam PNP, Muecksch F, Lee YE, Huey-Tubman KE, Schmidt F, Hatziioannou T, Bieniasz PD, Nussenzweig MC, West Jr AP, Keeffe JR, Bjorkman PJ, Barnes CO
Cell Rep (2021) 36 pp. 109760-109760 [ Pubmed: 34534459 DOI: doi:10.1016/j.celrep.2021.109760 ]
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7m6e
Q-score: 0.394
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Ternary complex of bg10-19 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg10-19 fab (Complex from Homo sapiens)
- Bg10-19 fab light chain (22 kDa, Protein from Homo sapiens)
- Bg10-19 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7m6f
Q-score: 0.32
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ternary complex of bg1-22 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Bg1-22 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Bg1-22 fab (Complex from Homo sapiens)
- Bg1-22 fab light chain (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7m6g
Q-score: 0.317
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Bg7-15 fab (Complex from Homo sapiens)
- Ternary complex of bg7-15 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg7-15 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg7-15 fab light chain (23 kDa, Protein from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7m6h
Q-score: 0.254
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Bg7-20 fab (Complex from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg7-20 fab light chain (22 kDa, Protein from Homo sapiens)
- Bg7-20 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ternary complex of bg7-20 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7m6i
Q-score: 0.277
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Ternary complex of bg1-24 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg1-24 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Bg1-24 fab light chain (23 kDa, Protein from Homo sapiens)
- Bg1-24 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 6orn
Q-score: 0.423
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 antibody fab light chain (23 kDa, Protein from Homo sapiens)
- 10-1074 antibody fab heavy chain (25 kDa, Protein from Homo sapiens)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- 10-1074 fab (Complex from Homo sapiens)
- Complex of rc1 variant of bg505 sosip.664 trimer with three 10-1074 fabs and three cd4bs fabs (600 kDa, Complex from Human immunodeficiency virus 1)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6oro
Q-score: 0.465
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Complex of rc1 variant of bg505 sosip.664 trimer with three elicted ab874nhp fabs and three human bnab 8anc195 fabs (150 kDa, Complex from Human immunodeficiency virus 1)
- Ab874nhp fab (Complex from Macaca mulatta)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Ab874nhp antibody fab light chain (24 kDa, Protein from Macaca mulatta)
- Ab874nhp antibody fab heavy chain (26 kDa, Protein from Macaca mulatta)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6orp
Q-score: 0.358
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- Ab897nhp fab (Complex from Macaca mulatta)
- Ab897nhp antibody fab light chain (24 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ab897nhp antibody fab heavy chain (26 kDa, Protein from Macaca mulatta)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Complex of rc1 variant of bg505 sosip.664 trimer with three ab897nhp fabs and three 8anc195 fabs (600 kDa, Complex from Human immunodeficiency virus 1)