Structure of the human ACE2 receptor in complex with antibody Fab fragment, 05B04
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8e7m
Q-score: 0.427
Zhang F, Jenkins J, de Carvalho RV, Nakandakari-Higa S, Chen T, Abernathy ME, Nyakatura E, Andrew D, Lebedeva I, Lorenz IC, Hoffmann HH, Rice CM, Victora GD, Barnes CO, Haziioannou T, Bieniasz PD
bioRxiv (2022) [ DOI: doi:10.1101/2022.08.24.505169 ]
- Hace2 + 05b04 fab fragment (100 kDa, Complex from Homo sapiens)
- 05b04 light chain (23 kDa, Protein from Homo sapiens)
- Angiotensin-converting enzyme 2 (72 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 05b04 heavy chain (23 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7uap
Q-score: 0.384
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
Immunity (2022) 55 pp. 998-1012.e8 [ DOI: doi:10.1016/j.immuni.2022.04.003 Pubmed: 35447092 ]
- C1520 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- C1520 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s 6p + c1520 fab fragments (700 kDa, Complex from Homo sapiens)
Structure of the SARS-CoV-2 NTD in complex with C1520, local refinement
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uaq
Q-score: 0.39
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
Immunity (2022) 55 pp. 998-1012.e8 [ DOI: doi:10.1016/j.immuni.2022.04.003 Pubmed: 35447092 ]
- C1520 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- C1520 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s 6p + c1520 fab fragments (700 kDa, Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7uar
Q-score: 0.444
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
Immunity (2022) 55 pp. 998-1012.e8 [ DOI: doi:10.1016/j.immuni.2022.04.003 Pubmed: 35447092 ]
- Sars-cov-2 s 6p + c1717 fab fragments (700 kDa, Complex from Homo sapiens)
- C1717 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C1717 fab light chain (22 kDa, Protein from Homo sapiens)
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
Immunity (2022) 55 pp. 998-1012.e8 [ DOI: doi:10.1016/j.immuni.2022.04.003 Pubmed: 35447092 ]
- Sars-cov-2 s 6p + c1791 fab fragments (700 kDa, Complex from Homo sapiens)
Modified BG505 SOSIP-based immunogen RC1 in complex with elicited mAb Ab283MUR Fab and 8ANC195 Fab
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
- 8anc195 fab (Complex from Homo sapiens)
- Rc1 sosip (Complex from Human immunodeficiency virus 1)
- Ab283mur fab (Complex from Mus musculus)
- Elicited ab283mur fab in complex with rc1 sosip and bnab 8anc195 fab (600 kDa, Complex)
Modified BG505 SOSIP-based immunogen RC1 in complex with elicited mAb Ab1170NHP Fab and 8ANC195 Fab
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Prime polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 1 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 2 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]