Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 mature fab heavy chain (13 kDa, Protein from Homo sapiens)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24 fabs with an inferred germline light chain and 10-1074 fabs in complex with hiv-1 env immunogen bg505-sosipv4.1-gt1 containing the n276 gp120 glycan- class 1 (Complex from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (49 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 mature fab light chain (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ugq
Q-score: 0.47
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
- Bg24 with an inferred germline cdrl1 fab light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24 fabs with an inferred germline cdrl1 and 10-1074 fabs in complex with hiv-1 env 6405-sosip.664 (Complex from Human immunodeficiency virus 1)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (50 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 with an inferred germline cdrl1 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7ugn
Q-score: 0.477
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
- Envelope glycoprotein gp120 (50 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 inferred germline fab with germline cdr3s light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em map of bg24-igl cdr3igl and 10-1074 fabs in complex with bg505 sosip.664v4.1-gt1 env trimer immunogen (Complex from Human immunodeficiency virus 1)
- Alpha-d-mannopyranose (180 Da, Ligand)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Bg24 inferred germline fab with germline cdr3s heavy chain (13 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7ugo
Q-score: 0.425
Dam KA, Barnes CO, Gristick HB, Schoofs T, Gnanapragasam PNP, Nussenzweig MC, Bjorkman PJ
Nat Commun (2022) 13 pp. 6123-6123 [ DOI: doi:10.1038/s41467-022-33860-2 Pubmed: 36253376 ]
- Alpha-d-mannopyranose (180 Da, Ligand)
- 10-1074 fab light chain (11 kDa, Protein from Homo sapiens)
- Bg24 inferred germline fab with mature cdr3s heavy chain (13 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 inferred germline fab with mature cdr3s light chain (11 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (14 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 fab heavy chain (14 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em map of bg24-igl cdr3mat and 10-1074 fabs in complex with bg505 sosip.664v4.1-gt1 env trimer immunogen (Complex from Human immunodeficiency virus 1)
Wang Z, Schmidt F, Weisblum Y, Muecksch F, Barnes CO, Finkin S, Schaefer-Babajew D, Cipolla M, Gaebler C, Lieberman JA, Oliveira TY, Yang Z, Abernathy ME, Huey-Tubman KE, Hurley A, Turroja M, West KA, Gordon K, Millard KG, Ramos V, Da Silva J, Xu J, Colbert RA, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Gazumyan A, Caskey M, Bjorkman PJ, Casellas R, Hatziioannou T, Bieniasz PD, Nussenzweig MC
Nature (2021) 592 pp. 616-622 [ DOI: doi:10.1038/s41586-021-03324-6 Pubmed: 33567448 ]
- Sars-cov-2 spike glycoprotein 6p trimer (585 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- C601 fab (50 kDa, Complex from Homo sapiens)
- Sars-cov-2 s 6p trimer complexed with monoclonal fab c601 (600 kDa, Complex)
Wang Z, Schmidt F, Weisblum Y, Muecksch F, Barnes CO, Finkin S, Schaefer-Babajew D, Cipolla M, Gaebler C, Lieberman JA, Oliveira TY, Yang Z, Abernathy ME, Huey-Tubman KE, Hurley A, Turroja M, West KA, Gordon K, Millard KG, Ramos V, Da Silva J, Xu J, Colbert RA, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Gazumyan A, Caskey M, Bjorkman PJ, Casellas R, Hatziioannou T, Bieniasz PD, Nussenzweig MC
Nature (2021) 592 pp. 616-622 [ DOI: doi:10.1038/s41586-021-03324-6 Pubmed: 33567448 ]
- C603 fab (50 kDa, Complex from Homo sapiens)
- Sars-cov-2 spike glycoprotein 6p trimer (585 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s 6p trimer complexed with monoclonal fab c601 (600 kDa, Complex)
Wang Z, Schmidt F, Weisblum Y, Muecksch F, Barnes CO, Finkin S, Schaefer-Babajew D, Cipolla M, Gaebler C, Lieberman JA, Oliveira TY, Yang Z, Abernathy ME, Huey-Tubman KE, Hurley A, Turroja M, West KA, Gordon K, Millard KG, Ramos V, Da Silva J, Xu J, Colbert RA, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Gazumyan A, Caskey M, Bjorkman PJ, Casellas R, Hatziioannou T, Bieniasz PD, Nussenzweig MC
Nature (2021) 592 pp. 616-622 [ DOI: doi:10.1038/s41586-021-03324-6 Pubmed: 33567448 ]
- Sars-cov-2 spike glycoprotein 6p trimer (585 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- C643 fab (50 kDa, Complex from Homo sapiens)
- Sars-cov-2 s 6p trimer complexed with monoclonal fab c601 (600 kDa, Complex)