Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ucg
Q-score: 0.411
Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West Jr AP, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ
Sci Adv (2022) 8 pp. eabp8155-eabp8155 [ Pubmed: 35960796 DOI: doi:10.1126/sciadv.abp8155 ]
- 10-1074 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of du422 sosip trimer bound to 10-1074 and bg24 fab fragments (650 kDa, Complex from Homo sapiens)
- 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Bg24 light chain (21 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 cdrh2-v2 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (56 kDa, Protein from Human immunodeficiency virus 1)
Modified BG505 SOSIP-based immunogen RC1 in complex with elicited mAb Ab283MUR Fab and 8ANC195 Fab
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
- 8anc195 fab (Complex from Homo sapiens)
- Rc1 sosip (Complex from Human immunodeficiency virus 1)
- Ab283mur fab (Complex from Mus musculus)
- Elicited ab283mur fab in complex with rc1 sosip and bnab 8anc195 fab (600 kDa, Complex)
Modified BG505 SOSIP-based immunogen RC1 in complex with elicited mAb Ab1170NHP Fab and 8ANC195 Fab
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Prime polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 1 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 2 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 3 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 4 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with NHP 1 post-Prime polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with NHP 1 post-Boost 1 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]