Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ucg
Q-score: 0.411
Barnes CO, Schoofs T, Gnanapragasam PNP, Golijanin J, Huey-Tubman KE, Gruell H, Schommers P, Suh-Toma N, Lee YE, Cetrulo Lorenzi JC, Piechocka-Trocha A, Scheid JF, West Jr AP, Walker BD, Seaman MS, Klein F, Nussenzweig MC, Bjorkman PJ
Sci Adv (2022) 8 pp. eabp8155-eabp8155 [ Pubmed: 35960796 DOI: doi:10.1126/sciadv.abp8155 ]
- 10-1074 fab heavy chain (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of du422 sosip trimer bound to 10-1074 and bg24 fab fragments (650 kDa, Complex from Homo sapiens)
- 10-1074 light chain (23 kDa, Protein from Homo sapiens)
- Bg24 light chain (21 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg24 cdrh2-v2 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (56 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7m6e
Q-score: 0.394
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Ternary complex of bg10-19 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg10-19 fab (Complex from Homo sapiens)
- Bg10-19 fab light chain (22 kDa, Protein from Homo sapiens)
- Bg10-19 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7m6f
Q-score: 0.32
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ternary complex of bg1-22 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Bg1-22 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Bg1-22 fab (Complex from Homo sapiens)
- Bg1-22 fab light chain (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7m6g
Q-score: 0.317
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Bg7-15 fab (Complex from Homo sapiens)
- Ternary complex of bg7-15 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg7-15 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg7-15 fab light chain (23 kDa, Protein from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7m6h
Q-score: 0.254
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Bg7-20 fab (Complex from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg7-20 fab light chain (22 kDa, Protein from Homo sapiens)
- Bg7-20 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ternary complex of bg7-20 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7m6i
Q-score: 0.277
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Ternary complex of bg1-24 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg1-24 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Bg1-24 fab light chain (23 kDa, Protein from Homo sapiens)
- Bg1-24 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 7kde
Q-score: 0.514
Wang Z, Barnes CO, Gautam R, Cetrulo Lorenzi JC, Mayer CT, Oliveira TY, Ramos V, Cipolla M, Gordon KM, Gristick HB, West AP, Nishimura Y, Raina H, Seaman MS, Gazumyan A, Martin M, Bjorkman PJ, Nussenzweig MC, Escolano A
eLife (2020) 9 [ Pubmed: 33084569 DOI: doi:10.7554/eLife.61991 ]
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ab 1485 heavy chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ab 1485 light chain (23 kDa, Protein from Homo sapiens)
- Ternary complex of hiv-1 env glycoprotein, bg505. sosip.664, with broadly neutralizing antibodies 1485 and 8anc195 (600 kDa, Complex from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- 8anc195 fab light chain (23 kDa, Protein from Homo sapiens)
- 8anc195 fab heavy chain (26 kDa, Protein from Homo sapiens)
HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6udj
Q-score: 0.632
Schommers P, Gruell H, Abernathy ME, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fatkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F
Cell (2020) 180 pp. 471- [ DOI: doi:10.1016/j.cell.2020.01.010 Pubmed: 32004464 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Water (18 Da, Ligand)
- Complex of bnabs 1-18 and 10-1074 in complex with bg505 sosip.664 trimer (300 kDa, Complex)
- 1-18 fab heavy chain (53 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-18 fab (Complex from Homo sapiens)
- 1-18 fab light chain (25 kDa, Protein from Homo sapiens)
- 10-1074 fab light chain (23 kDa, Protein from Homo sapiens)
- 10-1074 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- 10-1074 fab (Complex from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6udk
Q-score: 0.442
Schommers P, Gruell H, Abernathy ME, Tran MK, Dingens AS, Gristick HB, Barnes CO, Schoofs T, Schlotz M, Vanshylla K, Kreer C, Weiland D, Holtick U, Scheid C, Valter MM, van Gils MJ, Sanders RW, Vehreschild JJ, Cornely OA, Lehmann C, Fatkenheuer G, Seaman MS, Bloom JD, Bjorkman PJ, Klein F
Cell (2020) 180 pp. 471- [ DOI: doi:10.1016/j.cell.2020.01.010 Pubmed: 32004464 ]
- Rc1 variant of hiv-1 bg505 sosip.664 (Complex from Human immunodeficiency virus 1)
- Complex of three bnab 1-55 fabs and three 10-1074 fabs bound to rc1 variant of bg505 sosip.664 trimer (300 kDa, Complex)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-55 fab light chain (25 kDa, Protein from Homo sapiens)
- 10-1074 fab light chain (23 kDa, Protein from Homo sapiens)
- 1-55 fab (Complex from Homo sapiens)
- 10-1074 fab (Complex from Homo sapiens)
- 10-1074 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 1-55 fab heavy chain (28 kDa, Protein from Homo sapiens)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 6orn
Q-score: 0.423
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 antibody fab light chain (23 kDa, Protein from Homo sapiens)
- 10-1074 antibody fab heavy chain (25 kDa, Protein from Homo sapiens)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- 10-1074 fab (Complex from Homo sapiens)
- Complex of rc1 variant of bg505 sosip.664 trimer with three 10-1074 fabs and three cd4bs fabs (600 kDa, Complex from Human immunodeficiency virus 1)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)