Structure of the Inmazeb cocktail and resistance to escape against Ebola virus
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7tn9
Q-score: 0.475
Rayaprolu V, Fulton BO, Rafique A, Arturo E, Williams D, Hariharan C, Callaway H, Parvate A, Schendel SL, Parekh D, Hui S, Shaffer K, Pascal KE, Wloga E, Giordano S, Negron N, Ni M, Copin R, Atwal GS, Franklin M, Boytz RM, Donahue C, Davey R, Baum A, Kyratsous CA, Saphire EO
Cell Host Microbe (2023) 31 pp. 260- [ Pubmed: 36708708 DOI: doi:10.1016/j.chom.2023.01.002 ]
- Regn3471 heavy chain (23 kDa, Protein from Mus musculus)
- Envelope glycoprotein (35 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Regn3479 light chain (23 kDa, Protein from Mus musculus)
- Regn3470 heavy chain (23 kDa, Protein from Mus musculus)
- Regn3471 heavy chain, regn3479 light chain, regn3471 light chain, regn3479 heavy chain, regn3470 heavy chain, regn3470 light chain (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Regn3471 light chain (24 kDa, Protein from Mus musculus)
- Regn3470 light chain (23 kDa, Protein from Mus musculus)
- Envelope glycoprotein, shed gp (Complex from Mus musculus)
- Inmazeb therapeutic cocktail (Complex)
- Regn3479 heavy chain (22 kDa, Protein from Mus musculus)
- Gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7m42
Q-score: 0.449
Copin R, Baum A, Wloga E, Pascal KE, Giordano S, Fulton BO, Zhou A, Negron N, Lanza K, Chan N, Coppola A, Chiu J, Ni M, Wei Y, Atwal GS, Hernandez AR, Saotome K, Zhou Y, Franklin MC, Hooper AT, McCarthy S, Hamon S, Hamilton JD, Staples HM, Alfson K, Carrion Jr R, Ali S, Norton T, Somersan-Karakaya S, Sivapalasingam S, Herman GA, Weinreich DM, Lipsich L, Stahl N, Murphy AJ, Yancopoulos GD, Kyratsous CA
Cell (2021) 184 pp. 3949- [ Pubmed: 34161776 DOI: doi:10.1016/j.cell.2021.06.002 ]
- Regn10989 antibody fab fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Regn10989 antibody fab fragment light chain (22 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 receptor binding domain with the fab fragments of neutralizing antibodies regn10985 and regn10989 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Regn10985 antibody fab fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Regn10985 antibody fab fragment light chain (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike D614G variant, minus RBD
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6xs6
Q-score: 0.468
Yurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J
Cell (2020) 183 pp. 739-751.e8 [ Pubmed: 32991842 DOI: doi:10.1016/j.cell.2020.09.032 ]
- Sars2 spike d614g (417 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6xdg
Q-score: 0.348
Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, Yan Y, Koon K, Patel K, Chung KM, Hermann A, Ullman E, Cruz J, Rafique A, Huang T, Fairhurst J, Libertiny C, Malbec M, Lee WY, Welsh R, Farr G, Pennington S, Deshpande D, Cheng J, Watty A, Bouffard P, Babb R, Levenkova N, Chen C, Zhang B, Romero Hernandez A, Saotome K, Zhou Y, Franklin M, Sivapalasingam S, Lye DC, Weston S, Logue J, Haupt R, Frieman M, Chen G, Olson W, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA
Science (2020) 369 pp. 1010-1014 [ DOI: doi:10.1126/science.abd0827 Pubmed: 32540901 ]
- Regn10987 antibody fab fragment light chain (22 kDa, Protein from Homo sapiens)
- Spike protein receptor binding domain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Regn10933 antibody fab fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Regn10987 antibody fab fragment heavy chain (24 kDa, Protein from Homo sapiens)
- Regn10987 antibody fab fragment (Complex from Homo sapiens)
- Complex of sars-cov-2 spike protein receptor binding domain with fab fragments of two neutralizing antibodies (Complex)
- Regn10933 antibody fab fragment (Complex from Homo sapiens)
- Regn10933 antibody fab fragment light chain (23 kDa, Protein from Homo sapiens)