The structure of the native cardiac thin filament junction region
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8dd0
Q-score: 0.443
Risi CM, Belknap B, White HD, Dryden K, Pinto JR, Chase PB, Galkin VE
Pnas Nexus (2023) 2 pp. pgac298-pgac298 [ Pubmed: 36712934 DOI: doi:10.1093/pnasnexus/pgac298 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Tropomyosin alpha-1 chain (32 kDa, Protein from Sus scrofa)
- Junction region of the native cardiac thin filament (Complex from Sus scrofa)
- Actin, alpha cardiac muscle 1 (42 kDa, Protein from Sus scrofa)
- Troponin t2, cardiac type (35 kDa, Protein from Sus scrofa)
Resolution: 8.0 Å
EM Method: Single-particle
Fitted PDBs: 7ko4
Q-score: 0.106
Risi CM, Pepper I, Belknap B, Landim-Vieira M, White HD, Dryden K, Pinto JR, Chase PB, Galkin VE
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2024288118 Pubmed: 33753506 ]
- Actin, alpha skeletal muscle (41 kDa, Protein from Sus scrofa)
- Cardiac native thin filament (Complex from Sus scrofa)
- Tropomyosin alpha-1 chain (32 kDa, Protein from Sus scrofa)
- Troponin c (18 kDa, Protein from Sus scrofa)
- Isoform 4 of troponin t, cardiac muscle (23 kDa, Protein from Sus scrofa)
- Troponin i, cardiac muscle (19 kDa, Protein from Sus scrofa)
Resolution: 7.8 Å
EM Method: Single-particle
Fitted PDBs: 7ko5
Q-score: 0.113
Risi CM, Pepper I, Belknap B, Landim-Vieira M, White HD, Dryden K, Pinto JR, Chase PB, Galkin VE
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2024288118 Pubmed: 33753506 ]
- Actin, alpha skeletal muscle (41 kDa, Protein from Sus scrofa)
- Structure of ca2+ bound cardiac native thin filament at pca=5.8 (Complex from Sus scrofa)
- Tropomyosin alpha-1 chain (32 kDa, Protein from Sus scrofa)
- Troponin c (18 kDa, Protein from Sus scrofa)
- Troponin t, cardiac muscle (23 kDa, Protein from Sus scrofa)
- Troponin i, cardiac muscle (19 kDa, Protein from Sus scrofa)
Resolution: 8.3 Å
EM Method: Single-particle
Fitted PDBs: 7ko7
Q-score: 0.112
Risi CM, Pepper I, Belknap B, Landim-Vieira M, White HD, Dryden K, Pinto JR, Chase PB, Galkin VE
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2024288118 Pubmed: 33753506 ]
- Actin, alpha skeletal muscle (41 kDa, Protein from Sus scrofa)
- Structure of ca2+ free / ca2+ bound cardiac native thin filament at pca=5.8 mode 1 (Complex from Sus Scofa)
- Tropomyosin alpha-1 chain (32 kDa, Protein from Sus scrofa)
- Troponin c (18 kDa, Protein from Sus scrofa)
- Troponin t, cardiac muscle (23 kDa, Protein from Sus scrofa)
- Troponin i, cardiac muscle (19 kDa, Protein from Sus scrofa)
Resolution: 8.1 Å
EM Method: Single-particle
Fitted PDBs: 7kon
Q-score: 0.112
Risi CM, Pepper I, Belknap B, Landim-Vieira M, White HD, Dryden K, Pinto JR, Chase PB, Galkin VE
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2024288118 Pubmed: 33753506 ]
- Structure of ca2+ free / ca2+ bound cardiac native thin filament at pca=5.8 mode 2 (Complex from Sus scrofa)
- Actin, alpha skeletal muscle (41 kDa, Protein from Sus scrofa)
- Tropomyosin alpha-1 chain (32 kDa, Protein from Sus scrofa)
- Troponin c (18 kDa, Protein from Sus scrofa)
- Troponin t, cardiac muscle (23 kDa, Protein from Sus scrofa)
- Troponin i, cardiac muscle (19 kDa, Protein from Sus scrofa)
Resolution: 7.8 Å
EM Method: Single-particle
Fitted PDBs: 7kor
Q-score: 0.113
Risi CM, Pepper I, Belknap B, Landim-Vieira M, White HD, Dryden K, Pinto JR, Chase PB, Galkin VE
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2024288118 Pubmed: 33753506 ]
- Native cardiac thin filament (Complex from Sus scrofa)
- Actin, alpha skeletal muscle (41 kDa, Protein from Sus scrofa)
- Tropomyosin alpha-1 chain (32 kDa, Protein from Sus scrofa)
- Troponin c (18 kDa, Protein from Sus scrofa)
- Troponin t, cardiac muscle (23 kDa, Protein from Sus scrofa)
- Troponin i, cardiac muscle (19 kDa, Protein from Sus scrofa)
Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments - "OPEN" state
Resolution: 11.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 5noj
Q-score: 0.143
Risi C, Eisner J, Belknap B, Heeley DH, White HD, Schroder GF, Galkin VE
PNAS (2017) 114 pp. 6782-6787 [ DOI: doi:10.1073/pnas.1700868114 Pubmed: 28607071 ]
- Magnesium ion (24 Da, Ligand)
- Native cardiac thin filaments (Cellular component from Sus scrofa)
- Actin, alpha skeletal muscle (40 kDa, Protein from Sus scrofa)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cardiac alpha tropomyosin (11 kDa, Protein from Sus scrofa)
Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments - "Blocked" state
Resolution: 11.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 5nog
Q-score: 0.111
Risi C, Eisner J, Belknap B, Heeley DH, White HD, Schroder GF, Galkin VE
PNAS (2017) 114 pp. 6782-6787 [ DOI: doi:10.1073/pnas.1700868114 Pubmed: 28607071 ]
- Magnesium ion (24 Da, Ligand)
- Cardiac alpha tropomyosin (11 kDa, Protein from Pig)
- Native cardiac thin filaments (Cellular component from Sus scrofa)
- Cardiac muscle alpha actin 1 (40 kDa, Protein from Pig)
- Adenosine-5'-diphosphate (427 Da, Ligand)
Ca2+-induced Movement of Tropomyosin on Native Cardiac Thin Filaments - "Closed" state
Resolution: 8.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 5nol
Q-score: 0.144
Risi C, Eisner J, Belknap B, Heeley DH, White HD, Schroder GF, Galkin VE
PNAS (2017) 114 pp. 6782-6787 [ DOI: doi:10.1073/pnas.1700868114 Pubmed: 28607071 ]
- Magnesium ion (24 Da, Ligand)
- Native cardiac thin filaments (Cellular component from Sus scrofa)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Cardiac muscle alpha actin 1 (40 kDa, Protein from Sus scrofa)
- Cardiac alpha tropomyosin (11 kDa, Protein from Sus scrofa)