ST171-bound serotonin 5-HT1A receptor - Gi Protein Complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8pjk
Q-score: 0.611
Ullrich A, Schneider J, Braz JM, Neu E, Staffen N, Stanek M, Blahova J, Hove T, Albert T, Allikalt A, Lober S, Bhardwaj K, Rodriguez-Rosado S, Fink E, Rasmussen T, Hubner H, Inoue A, Shoichet BK, Basbaum AJ, Bottcher B, Weikert D, Gmeiner P
bioRxiv (2023) [ DOI: doi:10.1101/2023.09.11.557127 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- St171-bound serotonin 5-ht1a receptor - gi protein complex (Complex from Homo sapiens)
- (2r)-1-(heptadecanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate (953 Da, Ligand)
- 6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{h}-1,4-benzoxazin-3-one (372 Da, Ligand)
- 5-hydroxytryptamine receptor 1a (51 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Befiradol-bound serotonin 5-HT1A receptor - Gi Protein Complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8pkm
Q-score: 0.468
Ullrich A, Schneider J, Braz JM, Neu E, Staffen N, Stanek M, Blahova J, Hove T, Albert T, Allikalt A, Lober S, Bhardwaj K, Rodriguez-Rosado S, Fink E, Rasmussen T, Hubner H, Inoue A, Shoichet BK, Basbaum AJ, Bottcher B, Weikert D, Gmeiner P
bioRxiv (2023) [ DOI: doi:10.1101/2023.09.11.557127 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- (2r)-1-(heptadecanoyloxy)-3-{[(r)-hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate (953 Da, Ligand)
- (3-chloranyl-4-fluoranyl-phenyl)-[4-fluoranyl-4-[[(5-methylpyridin-2-yl)methylamino]methyl]piperidin-1-yl]methanone (393 Da, Ligand)
- 5-hydroxytryptamine receptor 1a (51 kDa, Protein from Homo sapiens)
- Befiradol-bound serotonin 5-ht1a receptor - gi protein complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of the DNA polymerase holoenzyme E9-A20-D4 of vaccinia virus
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8q3r
Q-score: 0.26
Burmeister WP, Boutin L, Balestra AC, Groger H, Ballandras-Colas A, Hutin S, Kraft C, Grimm C, Bottcher B, Fischer U, Tarbouriech N, Iseni F
PLoS Pathog (2024) 20 pp. e1011652-e1011652 [ Pubmed: 38768256 DOI: doi:10.1371/journal.ppat.1011652 ]
- Dna polymerase (120 kDa, Protein from Vaccinia virus Copenhagen)
- Uracil-dna glycosylase (27 kDa, Protein from Vaccinia virus Copenhagen)
- Dna polymerase processivity factor component opg148 (49 kDa, Protein from Vaccinia virus Copenhagen)
- E9-a20-d4 dna polymerase holoenzyme (196 MDa, Complex from Vaccinia virus)
HBc-F97L premature secretion phenotype
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7pz9
Q-score: 0.574
Makbul C, Kraft C, Griessmann M, Rasmussen T, Katzenberger K, Lappe M, Pfarr P, Stoffer C, Stohr M, Wandinger AM, Bottcher B
Viruses (2021) 13 [ DOI: doi:10.3390/v13112115 Pubmed: 34834922 ]
HBc-F97L (premature secretion phenotype) in complex with Triton X-100
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7pzi
Q-score: 0.601
Makbul C, Kraft C, Griessmann M, Rasmussen T, Katzenberger K, Lappe M, Pfarr P, Stoffer C, Stohr M, Wandinger AM, Bottcher B
Viruses (2021) 13 [ DOI: doi:10.3390/v13112115 Pubmed: 34834922 ]
HBc-WT in complex with Triton X-100
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7pzk
Q-score: 0.571
Makbul C, Kraft C, Griessmann M, Rasmussen T, Katzenberger K, Lappe M, Pfarr P, Stoffer C, Stohr M, Wandinger AM, Bottcher B
Viruses (2021) 13 [ DOI: doi:10.3390/v13112115 Pubmed: 34834922 ]
HBc-F97L premature secretion phenotype
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7pzl
Q-score: 0.612
Makbul C, Kraft C, Griessmann M, Rasmussen T, Katzenberger K, Lappe M, Pfarr P, Stoffer C, Stohr M, Wandinger AM, Bottcher B
Viruses (2021) 13 [ DOI: doi:10.3390/v13112115 Pubmed: 34834922 ]
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7pzm
Q-score: 0.587
Makbul C, Kraft C, Griessmann M, Rasmussen T, Katzenberger K, Lappe M, Pfarr P, Stoffer C, Stohr M, Wandinger AM, Bottcher B
Viruses (2021) 13 [ DOI: doi:10.3390/v13112115 Pubmed: 34834922 ]
wt HBc capsid like particles in complex with inhibitory peptide SLLGRM and Triton X-100
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7pzn
Q-score: 0.556
Makbul C, Kraft C, Griessmann M, Rasmussen T, Katzenberger K, Lappe M, Pfarr P, Stoffer C, Stohr M, Wandinger AM, Bottcher B
Viruses (2021) 13 [ DOI: doi:10.3390/v13112115 Pubmed: 34834922 ]
- Capsid protein (21 kDa, Protein from Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979))
- Wt hbc copurified with triton x-100 and sllgrm (Complex from Hepatitis B virus ayw/France/Tiollais/1979)
- Fragment of triton x-100 (352 Da, Ligand)
- Sllgrm, modelled as poly-a,sllgrm, modelled as poly-a (1 kDa, Protein from Escherichia coli)
small conductance mechanosensitive channel YnaI mutant G149A/G152A
Flegler VJ, Rasmussen A, Rao S, Wu N, Zenobi R, Sansom MSP, Hedrich R, Rasmussen T, Bottcher B
PNAS (2020) 117 pp. 28754-28762 [ Pubmed: 33148804 DOI: doi:10.1073/pnas.2005641117 ]