Cryo-EM structure of human HGSNAT bound with Acetyl-CoA
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8vkj
Q-score: 0.562
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ Pubmed: 38918376 DOI: doi:10.1038/s41467-024-49614-1 ]
- Purified human hgsnat (73 kDa, Complex from Homo sapiens)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
Cryo-EM structure of human HGSNAT bound with Acetyl-CoA and substrate analog
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8vlg
Q-score: 0.523
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ Pubmed: 38918376 DOI: doi:10.1038/s41467-024-49614-1 ]
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- 4-methyl-2-oxo-2h-1-benzopyran-7-yl 2-amino-2-deoxy-beta-d-glucopyranoside (337 Da, Ligand)
- Purified human hgsnat (73 kDa, Complex from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human HGSNAT bound with CoA and product analog
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8vli
Q-score: 0.513
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ Pubmed: 38918376 DOI: doi:10.1038/s41467-024-49614-1 ]
- Coenzyme a (767 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- Purified human hgsnat (73 kDa, Complex from Homo sapiens)
- 4-methyl-2-oxo-2h-1-benzopyran-7-yl 2-acetamido-2-deoxy-beta-d-glucopyranoside (379 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human HGSNAT bound with CoA
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8vlu
Q-score: 0.533
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ Pubmed: 38918376 DOI: doi:10.1038/s41467-024-49614-1 ]
- Purified human hgsnat (73 kDa, Complex from Homo sapiens)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Coenzyme a (767 Da, Ligand)
Cryo-EM structure of human HGSNAT in inactive state
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8vlv
Q-score: 0.484
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ Pubmed: 38918376 DOI: doi:10.1038/s41467-024-49614-1 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- Purified human hgsnat (73 kDa, Cellular component from Homo sapiens)
Cryo-EM structure of human HGSNAT in transition state
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8vly
Q-score: 0.494
Zhao B, Cao Z, Zheng Y, Nguyen P, Bowen A, Edwards RH, Stroud RM, Zhou Y, Van Lookeren Campagne M, Li F
Nat Commun (2024) 15 pp. 5388-5388 [ Pubmed: 38918376 DOI: doi:10.1038/s41467-024-49614-1 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heparan-alpha-glucosaminide n-acetyltransferase (73 kDa, Protein from Homo sapiens)
- Purified human hgsnat (73 kDa, Cellular component from Homo sapiens)
Human Tom70 in complex with SARS CoV2 Orf9b
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7kdt
Q-score: 0.473
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Huttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbolle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss 3rd FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech Jr TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, Garcia-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ
Science (2020) 370 [ DOI: doi:10.1126/science.abe9403 Pubmed: 33060197 ]
- Orf9b-tom70 complex (Complex from Homo sapiens)
- Mitochondrial import receptor subunit tom70 (56 kDa, Protein from Homo sapiens)
- Orf9b protein (10 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Structure of the rat vesicular glutamate transporter 2 determined by single particle Cryo-EM
Li F, Eriksen J, Finer-Moore J, Chang R, Nguyen P, Bowen A, Myasnikov A, Yu Z, Bulkley D, Cheng Y, Edwards RH, Stroud RM
Science (2020) 368 pp. 893-897 [ Pubmed: 32439795 DOI: doi:10.1126/science.aba9202 ]