Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with N969K mutation
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8fa1
Q-score: 0.427
Yang K, Wang C, Kreutzberger AJB, White KI, Pfuetzner RA, Esquivies L, Kirchhausen T, Brunger AT
PNAS (2023) 120 pp. e2300360120-e2300360120 [ DOI: doi:10.1073/pnas.2300360120 Pubmed: 36940324 ]
- Spike protein s2' hr2 (4 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ferritin, dps family protein and spike protein s2' chimera (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hr1hr2 complex (40 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 Omicron HR1-42G complex
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8fa2
Q-score: 0.382
Yang K, Wang C, Kreutzberger AJB, White KI, Pfuetzner RA, Esquivies L, Kirchhausen T, Brunger AT
PNAS (2023) 120 pp. e2300360120-e2300360120 [ DOI: doi:10.1073/pnas.2300360120 Pubmed: 36940324 ]
Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with extended HR2
Resolution: 2.22 Å
EM Method: Single-particle
Fitted PDBs: 8czi
Q-score: 0.489
Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT
PNAS (2022) 119 pp. e2210990119-e2210990119 [ Pubmed: 36122200 DOI: doi:10.1073/pnas.2210990119 ]
Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex
Resolution: 2.09 Å
EM Method: Single-particle
Fitted PDBs: 7rzq
Q-score: 0.482
Yang K, Wang C, White KI, Pfuetzner RA, Esquivies L, Brunger AT
PNAS (2022) 119 pp. e2119467119-e2119467119 [ Pubmed: 35363556 DOI: doi:10.1073/pnas.2119467119 ]
- Sars-cov-2 hr1 linked to a scaffold,spike protein s2' (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hr1hr2 complex (40 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (4 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with D936Y mutation
Resolution: 2.27 Å
EM Method: Single-particle
Fitted PDBs: 7rzr
Q-score: 0.495
Yang K, Wang C, White KI, Pfuetzner RA, Esquivies L, Brunger AT
PNAS (2022) 119 pp. e2119467119-e2119467119 [ Pubmed: 35363556 DOI: doi:10.1073/pnas.2119467119 ]
- Sars-cov-2 hr1hr2 complex with d936y mutation (40 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hr1 d936y linked to a scaffold,spike protein s2' (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (4 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with L938F mutation
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 7rzs
Q-score: 0.452
Yang K, Wang C, White KI, Pfuetzner RA, Esquivies L, Brunger AT
PNAS (2022) 119 pp. e2119467119-e2119467119 [ Pubmed: 35363556 DOI: doi:10.1073/pnas.2119467119 ]
- Sars-cov-2 hr1hr2 complex with l938f mutation (40 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hr1 l938f linked to a scaffold,spike protein s2' (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (4 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with S940F mutation
Resolution: 2.35 Å
EM Method: Single-particle
Fitted PDBs: 7rzt
Q-score: 0.473
Yang K, Wang C, White KI, Pfuetzner RA, Esquivies L, Brunger AT
PNAS (2022) 119 pp. e2119467119-e2119467119 [ Pubmed: 35363556 DOI: doi:10.1073/pnas.2119467119 ]
- Sars-cov-2 hr1hr2 complex with s940f mutation (40 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hr1 s940f linked to a scaffold,spike protein s2' (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (4 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with A942S mutation
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 7rzu
Q-score: 0.441
Yang K, Wang C, White KI, Pfuetzner RA, Esquivies L, Brunger AT
PNAS (2022) 119 pp. e2119467119-e2119467119 [ Pubmed: 35363556 DOI: doi:10.1073/pnas.2119467119 ]
- Sars-cov-2 hr1 a942s linked to a scaffold,spike protein s2' (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hr1hr2 complex with a942s mutation (40 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (4 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 HR1HR2 fusion core complex with V1176F mutation
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 7rzv
Q-score: 0.485
Yang K, Wang C, White KI, Pfuetzner RA, Esquivies L, Brunger AT
PNAS (2022) 119 pp. e2119467119-e2119467119 [ Pubmed: 35363556 DOI: doi:10.1073/pnas.2119467119 ]
- Sars-cov-2 hr1hr2 complex with v1176f mutation (40 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hr1 linked to a scaffold,spike protein s2' (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (4 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Structure of the SARS-CoV-2 Omicron spike post-fusion bundle
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7tik
Q-score: 0.425
Yang K, Wang C, Kreutzberger AJB, White KI, Pfuetzner RA, Esquivies L, Kirchhausen T, Brunger AT
PNAS (2023) 120 pp. e2300360120-e2300360120 [ DOI: doi:10.1073/pnas.2300360120 Pubmed: 36940324 ]