Ser40 phosphorylated tyrosine hydroxylase
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
Partial structure of tyrosine hydroxylase lacking the first 35 residues in complex with dopamine.
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 7pim
Q-score: 0.213
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Tyrosine 3-monooxygenase (38 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase lacking the first 35 residues in complex with its inhibitor dopamine (Complex from Homo sapiens)
- Regulatory domain alpha-helix (1 kDa, Protein from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
- L-dopamine (153 Da, Ligand)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6zn2
Q-score: 0.232
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Tyrosine 3-monooxygenase (38 kDa, Protein from Homo sapiens)
- Ser-leu-ile-glu-asp-ala-arg-lys-glu-arg-glu-ala-ala-val-ala-ala-ala-ala (1 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase (Complex from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
- L-dopamine (153 Da, Ligand)
Full-length structure of the substrate-free tyrosine hydroxylase (apo-TH).
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7a2g
Q-score: 0.234
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Water (18 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Tyrosine hydroxylase (Complex from Homo sapiens)
- Tyrosine 3-monooxygenase (47 kDa, Protein from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6zvp
Q-score: 0.22
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- L-dopamine (153 Da, Ligand)
- Fe (iii) ion (55 Da, Ligand)
- Tyrosine 3-monooxygenase (51 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase in complex with dopamine (Complex from Homo sapiens)
Partial structure of the substrate-free tyrosine hydroxylase (apo-TH).
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6zzu
Q-score: 0.422
Bueno-Carrasco MT, Cuellar J, Flydal MI, Santiago C, Krakenes TA, Kleppe R, Lopez-Blanco JR, Marcilla M, Teigen K, Alvira S, Chacon P, Martinez A, Valpuesta JM
Nat Commun (2022) 13 pp. 74-74 [ DOI: doi:10.1038/s41467-021-27657-y Pubmed: 35013193 ]
- Water (18 Da, Ligand)
- Tyrosine 3-monooxygenase (38 kDa, Protein from Homo sapiens)
- Tyrosine hydroxylase (Complex from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
Cryo electron microscopy of SARS-CoV-2 spike in prefusion state
Melero R, Sorzano COS, Foster B, Vilas JL, Martínez M, Marabini R, Ramírez-Aportela E, Sanchez-Garcia R, Herreros D, Del Caño L, Losana P, Fonseca-Reyna YC, Conesa P, Wrapp D, Chacon P, McLellan JS, Tagare HD, Carazo JM
IUCrJ (2020) 7 [ DOI: 10.1107/s2052252520012725 Pubmed: 33063791 ]
Image sets:
Cryo electron microscopy of SARS-CoV-2 stabilized spike in prefusion state
Melero R, Sorzano COS, Foster B, Vilas JL, Martínez M, Marabini R, Ramírez-Aportela E, Sanchez-Garcia R, Herreros D, Del Caño L, Losana P, Fonseca-Reyna YC, Conesa P, Wrapp D, Chacon P, McLellan JS, Tagare HD, Carazo JM
IUCrJ (2020) 7 [ DOI: 10.1107/s2052252520012725 Pubmed: 33063791 ]
Image sets:
SARS-CoV-2 spike in prefusion state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6zow
Q-score: 0.451
Melero R, Sorzano COS, Foster B, Vilas JL, Martinez M, Marabini R, Ramirez-Aportela E, Sanchez-Garcia R, Herreros D, Del Cano L, Losana P, Fonseca-Reyna YC, Conesa P, Wrapp D, Chacon P, McLellan JS, Tagare HD, Carazo JM
IUCrJ (2020) 7 pp. 1059-1069 [ DOI: doi:10.1107/S2052252520012725 Pubmed: 33063791 ]
- Water (18 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Spike homotrimer in prefusion state (Complex from Severe acute respiratory syndrome coronavirus 2)
- Dimethyl sulfoxide (78 Da, Ligand)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in prefusion state (flexibility analysis, 1-up closed conformation)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6zp5
Q-score: 0.417
Melero R, Sorzano COS, Foster B, Vilas JL, Martinez M, Marabini R, Ramirez-Aportela E, Sanchez-Garcia R, Herreros D, Del Cano L, Losana P, Fonseca-Reyna YC, Conesa P, Wrapp D, Chacon P, McLellan JS, Tagare HD, Carazo JM
IUCrJ (2020) 7 pp. 1059-1069 [ DOI: doi:10.1107/S2052252520012725 Pubmed: 33063791 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike in prefusion state (flexibility analysis, 1-up closed conformation) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Dimethyl sulfoxide (78 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)