Cryo-EM structure of long form insulin receptor (IR-B) in the apo state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8u4b
Q-score: 0.388
An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E
Nat Commun (2024) 15 pp. 2609-2609 [ DOI: doi:10.1038/s41467-024-46990-6 Pubmed: 38521788 ]
- Insulin receptor (156 kDa, Protein from Homo sapiens)
- Long form insulin receptor in the apo state (Complex from Homo sapiens)
Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8u4c
Q-score: 0.359
An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E
Nat Commun (2024) 15 pp. 2609-2609 [ DOI: doi:10.1038/s41467-024-46990-6 Pubmed: 38521788 ]
- Insulin receptor (156 kDa, Protein from Homo sapiens)
- Long form insulin receptor (ir-b) with four igf2 bound, symmetric conformation. (Complex from Homo sapiens)
- Insulin-like growth factor ii (20 kDa, Protein from Homo sapiens)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8u4e
Q-score: 0.279
An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E
Nat Commun (2024) 15 pp. 2609-2609 [ DOI: doi:10.1038/s41467-024-46990-6 Pubmed: 38521788 ]
- Insulin receptor (156 kDa, Protein from Homo sapiens)
- Long form insulin receptor (ir-b) with three igf2 bound, asymmetric conformation. (Complex from Homo sapiens)
- Insulin-like growth factor ii (20 kDa, Protein from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8eyr
Q-score: 0.346
Li J, Wu J, Hall C, Bai XC, Choi E
eLife (2022) 11 [ DOI: doi:10.7554/eLife.81286 Pubmed: 36413010 ]
- Insulin-like growth factor i (21 kDa, Protein from Homo sapiens)
- Insulin-like growth factor 1 receptor (144 kDa, Protein from Mus musculus)
- Two igf1 bound full-length mouse igf1r mutant (four glycine residues inserted in the alpha-ct; igf1r-p674g4): symmetric conformation (Complex from Mus musculus)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8eyx
Q-score: 0.237
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 8eyy
Q-score: 0.22
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8ez0
Q-score: 0.387
Cryo-EM structure of insulin receptor (IR) bound with S597 peptide
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 8dtl
Q-score: 0.141
Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E
Nat Commun (2022) 13 pp. 5594-5594 [ Pubmed: 36151101 DOI: doi:10.1038/s41467-022-33274-0 ]
- Insulin receptor (153 kDa, Protein from Mus musculus)
- Insulin mimetic peptide s597 (3 kDa, Protein from synthetic construct)
- Insulin receptor bound with s597 peptide (Complex from Mus musculus)