Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8eyr
Q-score: 0.346
Li J, Wu J, Hall C, Bai XC, Choi E
eLife (2022) 11 [ Pubmed: 36413010 DOI: doi:10.7554/eLife.81286 ]
- Two igf1 bound full-length mouse igf1r mutant (four glycine residues inserted in the alpha-ct; igf1r-p674g4): symmetric conformation (Complex from Mus musculus)
- Insulin-like growth factor 1 receptor (144 kDa, Protein from Mus musculus)
- Insulin-like growth factor i (21 kDa, Protein from Homo sapiens)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8eyx
Q-score: 0.237
Resolution: 4.9 Å
EM Method: Single-particle
Fitted PDBs: 8eyy
Q-score: 0.22
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8ez0
Q-score: 0.387
Cryo-EM structure of insulin receptor (IR) bound with S597 peptide
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 8dtl
Q-score: 0.141
Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E
Nat Commun (2022) 13 pp. 5594-5594 [ Pubmed: 36151101 DOI: doi:10.1038/s41467-022-33274-0 ]
- Insulin receptor (153 kDa, Protein from Mus musculus)
- Insulin receptor bound with s597 peptide (Complex from Mus musculus)
- Insulin mimetic peptide s597 (3 kDa, Protein from synthetic construct)
Cryo-EM structure of insulin receptor (IR) bound with S597 component 2
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8dtm
Q-score: 0.506
Park J, Li J, Mayer JP, Ball KA, Wu J, Hall C, Accili D, Stowell MHB, Bai XC, Choi E
Nat Commun (2022) 13 pp. 5594-5594 [ Pubmed: 36151101 DOI: doi:10.1038/s41467-022-33274-0 ]
- Insulin receptor (153 kDa, Protein from Mus musculus)
- Insulin mimetic peptide s597 component 2 (2 kDa, Protein from synthetic construct)
- Insulin receptor bound with s597 component 2 (Complex from Mus musculus)
Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl1
Q-score: 0.433
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Full-length insulin receptor bound with site 1 binding deficient mutant insulin (a-v3e) (Complex)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7sl2
Q-score: 0.39
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- asymmetric conformation (Complex)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7sl3
Q-score: 0.417
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (a-l13r) -- symmetric conformation (Complex)
Resolution: 5.0 Å
EM Method: Single-particle
Fitted PDBs: 7sl4
Q-score: 0.258
Li J, Park J, Mayer JP, Webb KJ, Uchikawa E, Wu J, Liu S, Zhang X, Stowell MHB, Choi E, Bai XC
Nat Struct Mol Biol (2022) 29 pp. 357-368 [ Pubmed: 35361965 DOI: doi:10.1038/s41594-022-00750-6 ]
- Full-length insulin receptor bound with site 2 binding deficient mutant insulin (b-l17r) -- asymmetric conformation (Complex)
- Insulin receptor (155 kDa, Protein from Mus musculus)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)