3-fold symmetry face of adeno-associated virus-9 and human Interleukin 3 complex
Shay TF, Jang S, Brittain TJ, Chen X, Walker B, Tebbutt C, Fan Y, Wolfe DA, Arokiaraj CM, Sullivan EE, Ding X, Wang TY, Lei Y, Chuapoco MR, Chou TF, Gradinaru V
Nat Commun (2024) 15 pp. 7853-7853 [ DOI: doi:10.1038/s41467-024-52149-0 Pubmed: 39245720 ]
I1 symmetry applied adeno-associated virus-9 with human Interleukin 3
Shay TF, Jang S, Brittain TJ, Chen X, Walker B, Tebbutt C, Fan Y, Wolfe DA, Arokiaraj CM, Sullivan EE, Ding X, Wang TY, Lei Y, Chuapoco MR, Chou TF, Gradinaru V
Nat Commun (2024) 15 pp. 7853-7853 [ DOI: doi:10.1038/s41467-024-52149-0 Pubmed: 39245720 ]
Human p97/VCP structure with a triazole inhibitor (NSC799462/hexamer)
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8uv2
Q-score: 0.39
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- 3-(4-{[(4p)-5-{[(1r)-cyclohex-2-en-1-yl]sulfanyl}-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}-2,6-difluorophenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate (594 Da, Ligand)
- P97/vcp aaa+ atpase/nsc799462 (536 kDa, Complex from Homo sapiens)
Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC804515)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- N-[3-(2,5-difluoro-4-{[(4m)-5-(hexylsulfanyl)-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl]propanamide (513 Da, Ligand)
- P97/vcp aaa+ atpase r155h mutant/nsc804515 (536 kDa, Complex from Homo sapiens)
Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/up)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- P97/vcp aaa+ atpase r155h mutant/nsc819701 (536 kDa, Complex from Homo sapiens)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- 2-[(4p)-4-(4-{[(4p)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2h-1,2,3-triazol-2-yl]-1-[(2r,6s)-2,6-dimethylmorpholin-4-yl]ethan-1-one (624 Da, Ligand)
Human p97/VCP R155H mutant structure with a triazole inhibitor (NSC819701/down)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- P97/vcp aaa+ atpase r155h mutant/nsc819701 (536 kDa, Complex from Homo sapiens)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- 2-[(4p)-4-(4-{[(4p)-5-(cyclohexylsulfanyl)-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}-2,5-difluorophenyl)-2h-1,2,3-triazol-2-yl]-1-[(2r,6s)-2,6-dimethylmorpholin-4-yl]ethan-1-one (624 Da, Ligand)
Human p97/VCP structure with a triazole inhibitor (NSC799462/dodecamer)
Nandi P, DeVore K, Wang F, Li S, Walker JD, Truong TT, LaPorte MG, Wipf P, Schlager H, McCleerey J, Paquette W, Columbres RCA, Gan T, Poh YP, Fromme P, Flint AJ, Wolf M, Huryn DM, Chou TF, Chiu PL
Commun Chem (2024) 7 pp. 177-177 [ DOI: doi:10.1038/s42004-024-01267-3 Pubmed: 39122922 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- 3-(2,6-difluoro-4-{[(4p)-5-{[(2s)-hexan-2-yl]sulfanyl}-4-(pyridin-3-yl)-4h-1,2,4-triazol-3-yl]methoxy}phenyl)prop-2-yn-1-yl (1-methylpiperidin-4-yl)carbamate (598 Da, Ligand)
- Transitional endoplasmic reticulum atpase (89 kDa, Protein from Homo sapiens)
- P97/vcp aaa+ atpase/nsc799462 (536 kDa, Complex from Homo sapiens)
Structure of the human BOS complex in GDN
Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Hazu M, Wang TY, Chou TF, Voorhees RM
Mol Cell (2024) 84 pp. 3302-3319.e11 [ Pubmed: 39173640 DOI: doi:10.1016/j.molcel.2024.08.005 ]
- Human bos complex (Complex from Homo sapiens)
Structure of the human truncated BOS complex in GDN
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 9c7u
Q-score: 0.442
Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Hazu M, Wang TY, Chou TF, Voorhees RM
Mol Cell (2024) 84 pp. 3302- [ Pubmed: 39173640 DOI: doi:10.1016/j.molcel.2024.08.005 ]
- Human truncated bos complex (Complex from Homo sapiens)
- Bos complex subunit nomo2 (42 kDa, Protein from Homo sapiens)
- Transmembrane protein 147 (25 kDa, Protein from Homo sapiens)
- Nicalin (63 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the human BOS:human EMC complex in GDN
Resolution: 6.6 Å
EM Method: Single-particle
Fitted PDBs: 9c7v
Q-score: 0.166
Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Hazu M, Wang TY, Chou TF, Voorhees RM
Mol Cell (2024) 84 pp. 3302- [ Pubmed: 39173640 DOI: doi:10.1016/j.molcel.2024.08.005 ]
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Membrane magnesium transporter 1 (14 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- Human bos complex (Complex from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Nicalin (63 kDa, Protein from Homo sapiens)
- Transmembrane protein 147 (25 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Bos complex subunit nomo2 (139 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)