Cryo-EM structure of the DHA bound FFA1-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9k1c
Q-score: 0.462
Ke Y, Huang Y, Yi C, Ma L, Chu X, Wu B, Zhao Q, Han S
Cell Rep (2024) 43 pp. 115024-115024 [ DOI: doi:10.1016/j.celrep.2024.115024 Pubmed: 39616615 ]
- Free fatty acid receptor 1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Dha bound ffa1-gi complex (Complex from Homo sapiens)
- Docosa-4,7,10,13,16,19-hexaenoic acid (328 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the butyrate bound FFA2-Gi complex
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9k1d
Q-score: 0.478
Ke Y, Huang Y, Yi C, Ma L, Chu X, Wu B, Zhao Q, Han S
Cell Rep (2024) 43 pp. 115024-115024 [ DOI: doi:10.1016/j.celrep.2024.115024 Pubmed: 39616615 ]
- Butanoic acid (88 Da, Ligand)
- Cryo-em structure of the butyrate bound ffa2-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 2 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Structural insights into the activation mechanism of antimicrobial GBP1: Polymeric assembly of GBP1
Weismehl M, Chu X, Kutsch M, Lauterjung P, Herrmann C, Kudryashev M, Daumke O
EMBO J (2024) 43 pp. 615-636 [ DOI: doi:10.1038/s44318-023-00023-y Pubmed: 38267655 ]
Resolution: 26.8 Å
EM Method: Subtomogram averaging
Fitted PDBs: 8r1a
Q-score: 0.03
Weismehl M, Chu X, Kutsch M, Lauterjung P, Herrmann C, Kudryashev M, Daumke O
EMBO J (2024) 43 pp. 615-636 [ DOI: doi:10.1038/s44318-023-00023-y Pubmed: 38267655 ]
- Aluminum fluoride (83 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Membrane-bound oligomer of human guanylate-binding protein 1 (gbp1) (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Guanylate binding protein 1 (69 kDa, Protein from Homo sapiens)
Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8jru
Q-score: 0.438
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B
Nature (2023) 620 pp. 904-910 [ DOI: doi:10.1038/s41586-023-06420-x Pubmed: 37558880 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Nanobody 32 (13 kDa, Protein from Escherichia phage EcSzw-2)
- The glucagon receptor bound to beta-arrestin 1 (Complex from Homo sapiens)
- Ha signal peptide,hpc4 purification tag,glucagon receptor,c-terminal tail of vasopressin v2 receptor (54 kDa, Protein from Homo sapiens)
- Beta-arrestin 1 and single-chain fragment variable 30 (scfv30) (69 kDa, Protein from Bos taurus)
Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jrv
Q-score: 0.431
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B
Nature (2023) 620 pp. 904-910 [ DOI: doi:10.1038/s41586-023-06420-x Pubmed: 37558880 ]
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Nanobody 32 (13 kDa, Protein from Escherichia phage EcSzw-2)
- Glucagon (3 kDa, Protein from Homo sapiens)
- Ha signal peptide,hpc4 purification tag,glucagon receptor,c-terminal tail of vasopressin v2 receptor (54 kDa, Protein from Homo sapiens)
- Beta-arrestin 1 and single-chain fragment variable 30 (scfv30) (69 kDa, Protein from Homo sapiens)
- The glucagon receptor bound to glucagon and beta-arrestin 1 (Complex from Homo sapiens)
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode I)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8jcu
Q-score: 0.401
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ Pubmed: 37286794 DOI: doi:10.1038/s41422-023-00830-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of ly341495 (Complex from Homo sapiens)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
Cryo-EM structure of mGlu2-mGlu3 heterodimer in presence of LY341495 (dimerization mode II)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jcv
Q-score: 0.344
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ Pubmed: 37286794 DOI: doi:10.1038/s41422-023-00830-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of ly341495 (Complex from Homo sapiens)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jcw
Q-score: 0.434
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ Pubmed: 37286794 DOI: doi:10.1038/s41422-023-00830-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of ly341495 and nam563 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jcx
Q-score: 0.421
Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B
Cell Res (2023) 33 pp. 762-774 [ Pubmed: 37286794 DOI: doi:10.1038/s41422-023-00830-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 3,serine/threonine-protein kinase mtor (112 kDa, Protein from Homo sapiens)
- Mglu2-3 heterodimer in presence of ly341495 and nam563 (Complex from Homo sapiens)
- Metabotropic glutamate receptor 2,peptidyl-prolyl cis-trans isomerase fkbp1a (109 kDa, Protein from Homo sapiens)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)