Structure of positive allosteric modulator-bound active human calcium-sensing receptor
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7sil
Q-score: 0.562
Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR
PNAS (2021) 118 [ Pubmed: 34916296 DOI: doi:10.1073/pnas.2115849118 ]
- Phosphate ion (94 Da, Ligand)
- Isoform 1 of extracellular calcium-sensing receptor (99 kDa, Protein from Homo sapiens)
- 3-(2-chlorophenyl)-n-[(1r)-1-(3-methoxyphenyl)ethyl]propan-1-amine (303 Da, Ligand)
- Cyclomethyltryptophan (216 Da, Ligand)
- Homodimer human calcium sensing receptor (192 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of positive allosteric modulator-free active human calcium-sensing receptor
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7sim
Q-score: 0.555
Park J, Zuo H, Frangaj A, Fu Z, Yen LY, Zhang Z, Mosyak L, Slavkovich VN, Liu J, Ray KM, Cao B, Vallese F, Geng Y, Chen S, Grassucci R, Dandey VP, Tan YZ, Eng E, Lee Y, Kloss B, Liu Z, Hendrickson WA, Potter CS, Carragher B, Graziano J, Conigrave AD, Frank J, Clarke OB, Fan QR
PNAS (2021) 118 [ Pubmed: 34916296 DOI: doi:10.1073/pnas.2115849118 ]
- Phosphate ion (94 Da, Ligand)
- Isoform 1 of extracellular calcium-sensing receptor (99 kDa, Protein from Homo sapiens)
- Cyclomethyltryptophan (216 Da, Ligand)
- Homodimer human calcium sensing receptor (192 kDa, Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structural basis for gating and activation of RyR1 (30 uM Ca2+ dataset, all particles)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 5t15
Q-score: 0.398
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1-cs2 complex (Complex)
- Ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1,ryanodine receptor 1 (501 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of rabbit RyR1 (Ca2+-only dataset, class 1)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 5t9m
Q-score: 0.347
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Ryanodine receptor 1 (501 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1-cs2 complex (Complex)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of rabbit RyR1 (Ca2+-only dataset, class 2)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5t9n
Q-score: 0.368
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Ryanodine receptor 1 (501 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1-cs2 complex (Complex)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of rabbit RyR1 (Ca2+-only dataset, class 3)
Resolution: 5.8 Å
EM Method: Single-particle
Fitted PDBs: 5t9r
Q-score: 0.19
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Ryanodine receptor 1 (501 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1-cs2 complex (Complex)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of rabbit RyR1 (Ca2+-only dataset, class 4)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 5t9s
Q-score: 0.287
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Ryanodine receptor 1 (501 kDa, Protein from Oryctolagus cuniculus)
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryr1-cs2 complex (Complex)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 1)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5t9v
Q-score: 0.268
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr1-cs2 complex (Complex)
- Ryanodine receptor 1 (475 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 2)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 5ta3
Q-score: 0.275
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr1-cs2 complex (Complex)
- Ryanodine receptor 1 (475 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 1 2)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 5tal
Q-score: 0.303
des Georges A, Clarke OB, Zalk R, Yuan Q, Condon KJ, Grassucci RA, Hendrickson WA, Marks AR, Frank J
Cell (2016) 167 pp. 145-157.e17 [ Pubmed: 27662087 DOI: doi:10.1016/j.cell.2016.08.075 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ryr1-cs2 complex (Complex)
- Ryanodine receptor 1 (475 kDa, Protein from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Caffeine (194 Da, Ligand)
- Calcium ion (40 Da, Ligand)