Structure of lineage IV Lassa virus glycoprotein complex (strain Josiah)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ejd
Q-score: 0.373
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
Structure of lineage II Lassa virus glycoprotein complex (strain NIG08-A41)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8eje
Q-score: 0.391
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp1 (28 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
Structure of lineage V Lassa virus glycoprotein complex (strain Soromba-R)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8ejf
Q-score: 0.355
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Glycoprotein gp1 (29 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp2 (44 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
Structure of lineage VII Lassa virus glycoprotein complex (strain Togo/2016/7082)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 8ejg
Q-score: 0.429
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein gp1 (22 kDa, Protein from Lassa mammarenavirus)
Lassa virus glycoprotein complex (Josiah) bound to 12.1F Fab
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8ejh
Q-score: 0.406
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- 12.1f fab heavy chain (13 kDa, Protein from Homo sapiens)
- Lassa mammarenavirus gpc (425 kDa, Complex from Lassa mammarenavirus)
- 12.1f fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- Alpha-d-mannopyranose (180 Da, Ligand)
Lassa virus glycoprotein complex (Josiah) bound to 19.7E Fab
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8eji
Q-score: 0.39
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- Lassa mammarenavirus gpc (325 kDa, Complex from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- 19.7e fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- 19.7e fab heavy chain (13 kDa, Protein from Homo sapiens)
Lassa virus glycoprotein complex (Josiah) bound to S370.7 Fab
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8ejj
Q-score: 0.506
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ DOI: doi:10.1016/j.celrep.2023.112524 Pubmed: 37209096 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp1 (22 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- Lassa mammarenavirus gpc (425 kDa, Complex from Lassa mammarenavirus)
- S370.7 light chain fab (11 kDa, Protein from Homo sapiens)
- S370.7 heavy chain fab (14 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
Resolution: 3.97 Å
EM Method: Single-particle
Fitted PDBs: 7sgd
Q-score: 0.366
Brouwer PJM, Antanasijevic A, Ronk AJ, Muller-Krauter H, Watanabe Y, Claireaux M, Perrett HR, Bijl TPL, Grobben M, Umotoy JC, Schriek AI, Burger JA, Tejjani K, Lloyd NM, Steijaert TH, van Haaren MM, Sliepen K, de Taeye SW, van Gils MJ, Crispin M, Strecker T, Bukreyev A, Ward AB, Sanders RW
Cell Host Microbe (2022) 30 pp. 1759- [ DOI: doi:10.1016/j.chom.2022.10.018 Pubmed: 36400021 ]
I53-50 nanoparticle core reconstructed from GPC-I53-50NP by focused refinement
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 7sge
Q-score: 0.479
Brouwer PJM, Antanasijevic A, Ronk AJ, Muller-Krauter H, Watanabe Y, Claireaux M, Perrett HR, Bijl TPL, Grobben M, Umotoy JC, Schriek AI, Burger JA, Tejjani K, Lloyd NM, Steijaert TH, van Haaren MM, Sliepen K, de Taeye SW, van Gils MJ, Crispin M, Strecker T, Bukreyev A, Ward AB, Sanders RW
Cell Host Microbe (2022) 30 pp. 1759- [ DOI: doi:10.1016/j.chom.2022.10.018 Pubmed: 36400021 ]
Lassa virus glycoprotein construct (Josiah GPC-I53-50A) in complex with LAVA01 antibody
Resolution: 4.41 Å
EM Method: Single-particle
Fitted PDBs: 7sgf
Q-score: 0.292
Brouwer PJM, Antanasijevic A, Ronk AJ, Muller-Krauter H, Watanabe Y, Claireaux M, Perrett HR, Bijl TPL, Grobben M, Umotoy JC, Schriek AI, Burger JA, Tejjani K, Lloyd NM, Steijaert TH, van Haaren MM, Sliepen K, de Taeye SW, van Gils MJ, Crispin M, Strecker T, Bukreyev A, Ward AB, Sanders RW
Cell Host Microbe (2022) 30 pp. 1759- [ DOI: doi:10.1016/j.chom.2022.10.018 Pubmed: 36400021 ]
- Lava01 mab - light chain (12 kDa, Protein from Oryctolagus cuniculus)
- Lassa virus glycoprotein construct(josiah gpc-i53-50a) in complex with lava01 antibody (as fab fragment) (Complex from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gpc-i53-50a (73 kDa, Protein from Lassa mammarenavirus)
- Lava01 mab - heavy chain (15 kDa, Protein from Oryctolagus cuniculus)