BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody FP3
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8t2e
Q-score: 0.48
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Fp3 heavy chain, fp3 light chain (Complex from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody fp3 (470 kDa, Complex)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Fp3 light chain (8 kDa, Protein from Macaca mulatta)
- Fp3 heavy chain (11 kDa, Protein from Macaca mulatta)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody N289
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8t2f
Q-score: 0.424
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N289 light chain (8 kDa, Protein from Macaca mulatta)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- N289 heavy chain (9 kDa, Protein from Macaca mulatta)
- N289 heavy chain, n289 light chain (Complex from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody n289 (470 kDa, Complex)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF1
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8swv
Q-score: 0.506
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- If1 heavy chain (10 kDa, Protein from Macaca mulatta)
- If1 light chain (8 kDa, Protein from Macaca mulatta)
- If1 heavy chain, if1 light chain (Complex from Macaca mulatta)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 boost 2 in complex with nhp polyclonal antibody if1 (470 kDa, Complex)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF3
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8sww
Q-score: 0.471
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nhp polyclonal antibody if3 heavy chain, nhp polyclonal antibody if3 light chain (Complex from Macaca mulatta)
- Bg505 boost 2 in complex with nhp polyclonal antibody if3 (470 kDa, Complex)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Nhp polyclonal antibody if3 heavy chain (9 kDa, Protein from Macaca mulatta)
- Nhp polyclonal antibody if3 light chain (9 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody Base4
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8swx
Q-score: 0.43
Cottrell CA, Pratap PP, Cirelli KM, Carnathan DG, Enemuo CA, Antanasijevic A, Ozorowski G, Sewall LM, Gao H, Allen JD, Nogal B, Silva M, Bhiman J, Pauthner M, Irvine DJ, Montefiori D, Crispin M, Burton DR, Silvestri G, Crotty S, Ward AB
NPJ Vaccines (2024) 9 pp. 126-126 [ DOI: doi:10.1038/s41541-024-00918-9 Pubmed: 38997302 ]
- Base4 light chain (7 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Base4 heavy chain, base4 light chain (Complex from Macaca mulatta)
- Surface protein gp120, transmembrane protein gp41 (Complex from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Base4 heavy chain (9 kDa, Protein from Macaca mulatta)
- Bg505 boost 2 in complex with nhp polyclonal antibody base4 (470 kDa, Complex)
- Surface protein gp120 (58 kDa, Protein from Human immunodeficiency virus 1)
10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ Pubmed: 38816615 DOI: doi:10.1038/s41590-024-01833-w ]
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8t49
Q-score: 0.495
Steichen JM, Phung I, Salcedo E, Ozorowski G, Willis JR, Baboo S, Liguori A, Cottrell CA, Torres JL, Madden PJ, Ma KM, Sutton HJ, Lee JH, Kalyuzhniy O, Allen JD, Rodriguez OL, Adachi Y, Mullen TM, Georgeson E, Kubitz M, Burns A, Barman S, Mopuri R, Metz A, Altheide TK, Diedrich JK, Saha S, Shields K, Schultze SE, Smith ML, Schiffner T, Burton DR, Watson CT, Bosinger SE, Crispin M, Yates 3rd JR, Paulson JC, Ward AB, Sok D, Crotty S, Schief WR
Science (2024) 384 pp. eadj8321-eadj8321 [ Pubmed: 38753769 DOI: doi:10.1126/science.adj8321 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_03 light chain fv (11 kDa, Protein from Macaca mulatta)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip in complex with rm_n332_03 fab and rm20a3 fab (Complex from Macaca mulatta)
- Rm_n332_03 heavy chain fv (14 kDa, Protein from Macaca mulatta)
MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8t4a
Q-score: 0.466
Steichen JM, Phung I, Salcedo E, Ozorowski G, Willis JR, Baboo S, Liguori A, Cottrell CA, Torres JL, Madden PJ, Ma KM, Sutton HJ, Lee JH, Kalyuzhniy O, Allen JD, Rodriguez OL, Adachi Y, Mullen TM, Georgeson E, Kubitz M, Burns A, Barman S, Mopuri R, Metz A, Altheide TK, Diedrich JK, Saha S, Shields K, Schultze SE, Smith ML, Schiffner T, Burton DR, Watson CT, Bosinger SE, Crispin M, Yates 3rd JR, Paulson JC, Ward AB, Sok D, Crotty S, Schief WR
Science (2024) 384 pp. eadj8321-eadj8321 [ Pubmed: 38753769 DOI: doi:10.1126/science.adj8321 ]
- Rm_n332_36 heavy chain fv (14 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm_n332_36 light chain fv (11 kDa, Protein from Macaca mulatta)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip in complex with rm_n332_36 fab and rm20a3 fab (Complex from Macaca mulatta)
MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8t4b
Q-score: 0.483
Steichen JM, Phung I, Salcedo E, Ozorowski G, Willis JR, Baboo S, Liguori A, Cottrell CA, Torres JL, Madden PJ, Ma KM, Sutton HJ, Lee JH, Kalyuzhniy O, Allen JD, Rodriguez OL, Adachi Y, Mullen TM, Georgeson E, Kubitz M, Burns A, Barman S, Mopuri R, Metz A, Altheide TK, Diedrich JK, Saha S, Shields K, Schultze SE, Smith ML, Schiffner T, Burton DR, Watson CT, Bosinger SE, Crispin M, Yates 3rd JR, Paulson JC, Ward AB, Sok D, Crotty S, Schief WR
Science (2024) 384 pp. eadj8321-eadj8321 [ Pubmed: 38753769 DOI: doi:10.1126/science.adj8321 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip in complex with rm_n332_32 fab and rm20a3 fab (Complex from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm_n332_32 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Rm_n332_32 light chain fv (11 kDa, Protein from Macaca mulatta)
MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8t4d
Q-score: 0.509
Steichen JM, Phung I, Salcedo E, Ozorowski G, Willis JR, Baboo S, Liguori A, Cottrell CA, Torres JL, Madden PJ, Ma KM, Sutton HJ, Lee JH, Kalyuzhniy O, Allen JD, Rodriguez OL, Adachi Y, Mullen TM, Georgeson E, Kubitz M, Burns A, Barman S, Mopuri R, Metz A, Altheide TK, Diedrich JK, Saha S, Shields K, Schultze SE, Smith ML, Schiffner T, Burton DR, Watson CT, Bosinger SE, Crispin M, Yates 3rd JR, Paulson JC, Ward AB, Sok D, Crotty S, Schief WR
Science (2024) 384 pp. eadj8321-eadj8321 [ Pubmed: 38753769 DOI: doi:10.1126/science.adj8321 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm_n332_08 light chain fv (12 kDa, Protein from Macaca mulatta)
- Md65 n332-gt5 sosip gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Md65 n332-gt5 sosip in complex with rm_n332_08 fab and rm20a3 fab (Complex from Macaca mulatta)
- Rm20a3 light chain fv (13 kDa, Protein from Macaca mulatta)
- Rm20a3 heavy chain fv (13 kDa, Protein from Macaca mulatta)
- Rm_n332_08 heavy chain fv (14 kDa, Protein from Macaca mulatta)