AMC016 SOSIP.v4.2 in complex with PGV04 Fab
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7rso
Q-score: 0.349
Schorcht A, Cottrell CA, Pugach P, Ringe RP, Han AX, Allen JD, van den Kerkhof TLGM, Seabright GE, Schermer EE, Ketas TJ, Burger JA, van Schooten J, LaBranche CC, Ozorowski G, de Val N, Bader DLV, Schuitemaker H, Russell CA, Montefiori DC, van Gils MJ, Crispin M, Klasse PJ, Ward AB, Moore JP, Sanders RW
J Virol (2022) 96 pp. e0155221-e0155221 [ DOI: doi:10.1128/JVI.01552-21 Pubmed: 34669426 ]
- Pgv04 kappa chain (23 kDa, Protein from Homo sapiens)
- Amc016 sosip.v4.2 in complex with pgv04 fab (Complex from Human immunodeficiency virus 1)
- Amc016 gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Pgv04 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Amc016 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 6vfk
Q-score: 0.316
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ DOI: doi:10.1371/journal.ppat.1008665 Pubmed: 32780770 ]
- T33_dn10b (31 kDa, Protein from synthetic construct)
- De novo designed tetrahedral nanoparticle t33_dn10 displaying 4 copies of bg505-sosip trimer on the surface. nanoparticle consists of 12 copies of both subunits (bg505-sosip-t33_dn10a and t33_dn10b) (Complex from synthetic construct)
- Bg505-sosip-t33_dn10a (88 kDa, Protein from synthetic construct)
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 6vfl
Q-score: 0.404
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB
PLoS Pathog (2020) 16 pp. e1008665-e1008665 [ DOI: doi:10.1371/journal.ppat.1008665 Pubmed: 32780770 ]
- Bg505-sosipv5.2(7s) - gp120 (56 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505-sosipv5.2(7s) - gp41 (17 kDa, Protein from synthetic construct)
- Bg505-sosip reconstructed from the tetrahedral nanoparticle t33_dn10 by subparticle extraction and refinement (Complex from synthetic construct)
Single Particle Electron Cryo-Microscopy Reconstruction of BG505 SOSIP-I53-50NP
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6p6f
Q-score: 0.301
Brouwer PJM, Antanasijevic A, Berndsen Z, Yasmeen A, Fiala B, Bijl TPL, Bontjer I, Bale JB, Sheffler W, Allen JD, Schorcht A, Burger JA, Camacho M, Ellis D, Cottrell CA, Behrens AJ, Catalano M, Del Moral-Sanchez I, Ketas TJ, LaBranche C, van Gils MJ, Sliepen K, Stewart LJ, Crispin M, Montefiori DC, Baker D, Moore JP, Klasse PJ, Ward AB, King NP, Sanders RW
Nat Commun (2019) 10 pp. 4272-4272 [ DOI: doi:10.1038/s41467-019-12080-1 Pubmed: 31537780 ]
- I53-50b.4pt1 (18 kDa, Protein from synthetic construct)
- I53-50b.4pt1 (Complex from synthetic construct)
- Two-component self-assembling nanoparticle consisting of bg505 sosip-i53-50a.1nt1 and i53-50b.4pt1 (Complex)
- I53-50a.1nt1 (99 kDa, Protein from synthetic construct)
- I53-50a.1nt1 (Complex from synthetic construct)