Structural basis for the nucleosome binding and chromatin compaction by the linker histone H5
Structural basis for the nucleosome binding and chromatin compaction by the linker histone H5
Structural basis for the linker histone H5-nucleosome binding and chromatin compaction
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8xjv
Q-score: 0.424
Li W, Hu J, Song F, Yu J, Peng X, Zhang S, Wang L, Hu M, Liu JC, Wei Y, Xiao X, Li Y, Li D, Wang H, Zhou BR, Dai L, Mou Z, Zhou M, Zhang H, Zhou Z, Zhang H, Bai Y, Zhou JQ, Li W, Li G, Zhu P
Cell Res (2024) 34 pp. 707-724 [ DOI: doi:10.1038/s41422-024-01009-z Pubmed: 39103524 ]
- Histone h2a (14 kDa, Protein from Xenopus laevis)
- Histone h4 (Complex from Xenopus laevis)
- Histone h2b (Complex from Xenopus laevis)
- Linker histone h5 (Complex from Gallus gallus)
- Histone h3 (15 kDa, Protein from Xenopus laevis)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone h5 (21 kDa, Protein from Gallus gallus)
- Dna (660 kDa, DNA from synthetic construct)
- 12x177bp-h5 chromatin (Complex)
- Dna (651 kDa, DNA from synthetic construct)
- Histone h3.1 (Complex from Xenopus laevis)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Widom 601 dna (Complex from synthetic construct)
- Histone h2a (Complex from Xenopus laevis)
CryoEM structure of NaDC1 with Citrate
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w6c
Q-score: 0.631
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ DOI: doi:10.1126/sciadv.adl3685 Pubmed: 38552027 ]
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Citric acid (192 Da, Ligand)
- Structure of nadc1 in complex with citrate (Complex from Homo sapiens)
CryoEM structure of NaDC1 in apo state
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8w6d
Q-score: 0.662
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ DOI: doi:10.1126/sciadv.adl3685 Pubmed: 38552027 ]
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Structure of nadc1 in apo state (Complex from Homo sapiens)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8w6g
Q-score: 0.552
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ DOI: doi:10.1126/sciadv.adl3685 Pubmed: 38552027 ]
- 2-[[(~{e})-3-(4-pentylphenyl)prop-2-enoyl]amino]benzoic acid (337 Da, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Nadc1 in complex with inhibitor n-(p-amylcinnamoyl)anthranilic acid (aca) (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Solute carrier family 13 member 2 (65 kDa, Protein from Homo sapiens)
NaS1 with sulfate - IN/IN state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w6h
Q-score: 0.567
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ DOI: doi:10.1126/sciadv.adl3685 Pubmed: 38552027 ]
- Sulfate ion (96 Da, Ligand)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
- Dimer of nas1 with sulfate in in/in state (Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Cholesterol (386 Da, Ligand)
NaS1 with sulfate in IN/OUT state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8w6n
Q-score: 0.536
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ DOI: doi:10.1126/sciadv.adl3685 Pubmed: 38552027 ]
- Sodium ion (22 Da, Ligand)
- Sulfate ion (96 Da, Ligand)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
- Structure of nas1 in complex with sulfate (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8w6o
Q-score: 0.58
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ DOI: doi:10.1126/sciadv.adl3685 Pubmed: 38552027 ]
- Cholesterol (386 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)
- Dimer of nas1 in in/in state (Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w6t
Q-score: 0.54
Chi X, Chen Y, Li Y, Dai L, Zhang Y, Shen Y, Chen Y, Shi T, Yang H, Wang Z, Yan R
Sci Adv (2024) 10 pp. eadl3685-eadl3685 [ DOI: doi:10.1126/sciadv.adl3685 Pubmed: 38552027 ]
- Dimer of nas1 in in/out state (Complex from Homo sapiens)
- Solute carrier family 13 member 1 (67 kDa, Protein from Homo sapiens)