KZ52 Fab fragment bound to Ebola GP, subtomogram average from a tight mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
KZ52 Fab fragment bound to Ebola GP, subtomogram average from a cylinder mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
3A6 Fab fragment bound to Ebola GP, subtomogram average from a cylinder mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
3A6 and KZ52 Fab fragments bound to Ebola GP, subtomogram average from a tight mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
3A6 and KZ52 Fab fragments bound to Ebola GP, subtomogram average from a cylinder mask
Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO
Nat Commun (2025) 16 pp. 1293-1293 [ DOI: doi:10.1038/s41467-025-56452-2 Pubmed: 39900911 ]
SARS-Cov2 S protein structure in complex with neutralizing monoclonal antibody 002-S21B10
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8gdr
Q-score: 0.411
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Keen M, Laughlin ZT, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund EA
To Be Published
- Antibody 002-s21b10 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (128 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Monoclonal antibody 002-s21b10 heavy chain variable domain (24 kDa, Protein from Homo sapiens)
- Antibody 002-s21b10 bound to spike glycoprotein trimer (Complex)
- Monoclonal antibody 002-s21b10 light chain variable domain (22 kDa, Protein from Homo sapiens)
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Keen M, Laughlin ZT, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund EA
To Be Published
Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Keen M, Laughlin ZT, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Murali-Krishna K, Chandele A, Ortlund EA
To Be Published
Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8dpl
Q-score: 0.536
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2.1.1d5 light chain variable domain (11 kDa, Protein from Homo sapiens)
- 6d6 single-chain variable fragment (25 kDa, Protein from Mus musculus)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Structure of ebov gp in complex with 2.1.1d5 scfv and 6d6 scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 heavy chain variable domain (13 kDa, Protein from Homo sapiens)
Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dpm
Q-score: 0.505
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- Antibody 9.20.1a2 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody 6d6 scfv (25 kDa, Protein from Mus musculus)
- Antibody 9.20.1a2 fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Complex of ebola virus glycoprotein trimer with 1a2 antibody fab and 6d6 antibody scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 9.20.1a2 fab heavy chain (13 kDa, Protein from Homo sapiens)